Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

作     者：Hua Bing Zhang Ji Jun Xue Xiao Long Zhao De Gang Liu Ying Li 

作者机构：State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 PR China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第6期

页      面：680-683页

核心收录：

学科分类：0710[理学-生物学] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 0703[理学-化学] 071002[理学-动物学] 0713[理学-生态学] 

基　　金：support of the National Natural Science Foundation of China(No.20672050) 

主　　题：Steroid Nitrogen mustards Synthesis Biological activity 

摘      要：Two novel steroid-linked nitrogen mustard conjugates la and lb were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate la exhibited obvious increasing of activities.