Synthesis and biological evaluation of novel steroid-linked nitrogen mustards
Synthesis and biological evaluation of novel steroid-linked nitrogen mustards作者机构:State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 PR China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2009年第20卷第6期
页 面:680-683页
核心收录:
学科分类:0710[理学-生物学] 083002[工学-环境工程] 0830[工学-环境科学与工程(可授工学、理学、农学学位)] 07[理学] 08[工学] 0703[理学-化学] 071002[理学-动物学] 0713[理学-生态学]
基 金:support of the National Natural Science Foundation of China(No.20672050)
主 题:Steroid Nitrogen mustards Synthesis Biological activity
摘 要:Two novel steroid-linked nitrogen mustard conjugates la and lb were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate la exhibited obvious increasing of activities.