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Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 990-996页

作者： Jing-yi ZHAO Yang LU Shou-ying du Xiao SONG Jie BAI Yue WANG Department of Industrial Pharmacy School of Chinese PharmacyBeijing University of Chinese MedicineBeijing 100102China

Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese *** order to understand the blood and brain pharmacokinetics after intravenous,intranasal,or oral administration and to investigate the superiority and feasibility of intranasal administration,a simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the quantification of *** samples and brain were collected from mice at 1,3,5,10,20,30,60,90,and 120 min after intravenous,intranasal,or oral administration of borneol at a dosage of 30.0 mg/*** preparations were carried out by liquid-liquid extraction with an internal standard solution of *** pharmacokinetic parameters were calculated by the software of *** calibration curves were linear in the range of 0.11-84.24 μg/ml and 0.16-63.18 μg/g for borneol in plasma and brain,*** methodological and extraction recoveries were both in the range of 85%-115%.The intra-day and inter-day variabilities for plasma and brain samples were ≤5.00% relative standard deviation (RSD).The absolute bioavailabilities F of intranasal and oral administrations were 90.68% and 42.99%.The relative brain targeted coefficients Re of intranasal and oral administrations were 68.37% and 38.40%.The GC-FID method developed could be applied to determination and pharmacokinetic *** borneol from injection was distributed and metabolized fast without absorption *** borneol from oral administration was distributed more slowly and had the lowest absolute *** administration of borneol was quickly absorbed into the blood and brain,was easy to use and had a greater safety than infection,which makes it worthy of further development as an administration route for encephalopathy treatment.

关键词： Borneol Intravenous administration lntranasal administration Oral administration Pharmacokinetics

阿戈美拉汀分别联合文拉法辛、安慰剂对老年抑郁症患者BDNF、5-HT、FGF-22、ACTH水平的影响

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分子诊断与治疗杂志 2024年第6期16卷 1147-1151页

作者：杜颖李旭丹张士巧马占平衡水市第七人民医院精神科河北衡水053000 衡水市第七人民医院心理一科河北衡水053000

目的分析阿戈美拉汀分别联合文拉法辛、安慰剂对老年抑郁症患者脑源性神经生长因子(BDNF)、5-羟色胺(5-HT)、成纤维细胞生长因子-22(FGF-22)和促肾上腺皮质激素(ACTH)水平的影响。方法选取2022年1月至2023年6月衡水市第七人民医院收... 详细信息

目的分析阿戈美拉汀分别联合文拉法辛、安慰剂对老年抑郁症患者脑源性神经生长因子(BDNF)、5-羟色胺(5-HT)、成纤维细胞生长因子-22(FGF-22)和促肾上腺皮质激素(ACTH)水平的影响。方法选取2022年1月至2023年6月衡水市第七人民医院收治的老年抑郁症患者110例,采用随机数字表法分为A组(阿戈美拉汀联合安慰剂,n=55)以及B组(阿戈美拉汀联合文拉法辛,n=55),均连续进行治疗12周。比较两组治疗12周后临床疗效,比较两组治疗前、治疗12周后血清BDNF、5-HT、FGF-22、ACTH水平、心率变异性指标、韦氏成人记忆量表(WMS-RC)评分,比较两组不同时间点汉密顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)评分。结果 B组的临床总有效率高于A组,差异有统计学意义(P<0.05)。与治疗前比较,两组血清ACTH水平均降低,且B组低于A组,血清BDNF、5-HT、FGF-22水平、频域总值(TP)、正常RR间期标准差(SDNN)、高频(HF)、低频(LF)、WMS-RC各个评分均升高,且B组高于A组,差异有统计学意义(P<0.05)。与治疗前比较,治疗3~12周后两组HAMD、PSQI评分均逐渐降低,且B组低于A组,差异有统计学意义(P<0.05)。结论应用阿戈美拉汀联合文拉法辛能够改善老年抑郁症患者心率变异性,调节患者神经系统相关因子水平提高患者认知功能的同时疗效显著。

关键词：文拉法辛阿戈美拉汀脑源性神经生长因子 5-羟色胺成纤维细胞生长因子-22 促肾上腺皮质激素

Microalgae wet extraction using N-ethyl butylamine for fatty acid production

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Green Energy & Environment 2016年第1期1卷 79-83页

作者： ying du Boelo Schuur Sascha R.A.Kersten Derk W.F.Brilman University of Twente Sustainable Process Technology Group(SPT)Faculty of Science and Technology

Microalgae are considered a promising feedstock for the production of food ingredients, cosmetics, pharmaceutical products and *** energy intensity of drying and cell breaking of algae and solvent recovery afterwards hindered the route of algae biorefinery. In this work the influences of freeze drying and cell breaking to the extraction efficiency of crude lipid yield and fatty acid yield were investigated. Results showed that drying and cell breaking are not necessary for N-ethyl butylamine extraction, because good yields were obtained without. Crude lipid yield and fatty acid yield using N-ethyl butylamine were comparable with Bligh & Dyer extraction, making N-ethyl butylamine a candidate for further development of an energy efficient lipid extraction technology for non-broken microalgae.

关键词： Microalgae Lipids Extraction Switchable solvent Secondary amine

Genetic Diversity Caused by Environmental Stress in Natural Populations of Niupidujuan as Revealed by RAPD Technique

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Chemical Research in Chinese Universities 2011年第4期27卷 641-645页

作者： du ying-da XING Ming YANG Zhi-yong LIU Yan-fei CHEN Xia College of Life Science Jilin University Changchun 130012 P. R. China

Multiplex environmental factors are generally expected to have significant effects on genetic diversity of plant *** this study,randomly amplified polymorphic DNA（RAPD） technique was used to reveal the genetic diversity in the same species of four populations collected from Niupidujuan（Rhododendron chrysanthum） at different altitudes,an endangered species,endemic to Northeast ***,twenty informative and reproducible primers were chosen for final RAPD analysis.A total of 152 clear bands were obtained,including 143 polymorphic *** the help of POPGENE software,the poly rate was calculated to be 94.07% and the evenness of amplified bands for every primer was ***,the mean observed number of alleles was 1.7265 with an effective number of *** examination of the gene indicated a diversity of 0.2162 with an information diversity index of *** these data,the clustering blurred analysis was performed with the aid of NTSYS-pc software to define the Nei＇s gene diversity and the Shannon information diversity index of the four plant *** relationships between the genetic diversity indexes on the one hand and the geographic and climatic factors on the other hand were estimated by the Pearson correlation with SPSS 11.0 *** results of the correlation analysis show that there were significant（P〈0.05） or highly significant（P〈0.01） correlations between each of the genetic diversity indexes and the different temperature which were mainly caused by the altitude different populations *** data highlight the importance of native populations in shaping the spatial genetic structure in Niupidujuan.

关键词： Environmental stress Genetic diversity Randomly amplified polymorphic DNA(RAPD) Clustering blurred analysis

保留眼轮匝肌的小切口重睑成形术在临床的应用

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中国医疗美容 2024年第3期14卷 1-5页

作者：刘凤华程爱花杜迎王璟济南明水眼科医院美容整形科山东济南250200

目的探讨一种恢复期短,损伤轻,维持时间稳定,形态自然的重睑手术方法;方法自2021年12月至2022年12月收集76例重睑就医者,按不同的手术方法,将上睑皮肤组织较薄,松弛不明显的分为观察组38例,另将上睑皮肤松弛较明显的分为对照组38例。观... 详细信息

目的探讨一种恢复期短,损伤轻,维持时间稳定,形态自然的重睑手术方法;方法自2021年12月至2022年12月收集76例重睑就医者,按不同的手术方法,将上睑皮肤组织较薄,松弛不明显的分为观察组38例,另将上睑皮肤松弛较明显的分为对照组38例。观察组采用保留眼轮匝肌的小切口重睑成形术,对照组采用传统的切开重睑成形术。结果观察组重睑切口长度、重睑手术时间、重睑切口愈合时间均明显低于对照组,差异对比有统计学意义(P<0.05)。观察组术后重睑形态评分、皮肤感觉评分和皮肤完整度及颜色评分均高于对照组,并发症低于对照组,差异对比有统计学意义(P<0.05)。结论保留眼轮匝肌的小切口重睑成形术因组织损伤少,血液循环及淋巴循环建立快,因此恢复期短,效果稳定,自然度高,满意率也较高,值得临床推广。

关键词：小切口重睑术传统切开法眼轮匝肌微创自然

大连市油漆和涂料生产行业二甲苯的环境及生物暴露水平监测

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工业卫生与职业病 2024年第3期50卷 244-246页

作者：王艳艳邵小翠杜影姜红梅大连市疾病预防控制中心职业放射卫生科辽宁大连116033

目的综合评价二甲苯在油漆和涂料生产行业的职业危害情况,为保护职业性接触二甲苯工人健康提供环境和生物暴露指标。方法选择大连市7家油漆和涂料生产企业,选用个体采样法测定工作场所空气中二甲苯的浓度及当日工作班末工人尿液中甲基... 详细信息

目的综合评价二甲苯在油漆和涂料生产行业的职业危害情况,为保护职业性接触二甲苯工人健康提供环境和生物暴露指标。方法选择大连市7家油漆和涂料生产企业,选用个体采样法测定工作场所空气中二甲苯的浓度及当日工作班末工人尿液中甲基马尿酸的含量,应用秩和检验和Spearman相关性分析两者之间关联程度。结果工作场所二甲苯浓度超标率为9.3%,最高值为156.3 mg/m3,工人班末尿中甲基马尿酸超标率为18.6%,最高为1.20 g/gCr,是职业接触生物限值的4倍。经秩和检验,包装岗位工人尿中甲基马尿酸浓度高于投料(Z=2.118,P<0.05)和调色岗位(Z=2.128,P<0.05),研磨、搅拌岗位工人尿中甲基马尿酸浓度高于调色岗位(Z=2.124,P<0.05)。工作场所二甲苯的浓度与工人当日工作末尿中甲基马尿酸呈正相关。结论应重点关注该行业包装及研磨、搅拌岗位工人的二甲苯职业危害情况,保证职业病防护设施的有效性,为工人配备防毒面具和足够的滤毒盒,切实提高工人佩戴防毒面具的依从性。

关键词：油漆和涂料生产行业二甲苯甲基马尿酸生物监测

Serum proteomic profiling for autism using magnetic bead-assisted matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a pilot study

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World Journal of Pediatrics 2018年第3期14卷 233-237页

作者： Yan-Ni Chen Hui-ying du Zhuo-Yue Shi Li He Yu-ying He duan Wang Department of Health Care Xi’an Children’s HospitalXi’an Jiaotong University69 XijuyuanxiangXi’an 710002China Department of Biology College of Liberal Arts and ScienceThe University of Io waIowaUSA Department of P ediatrics Shaanxi University of Chinese MedicineXianyangShannxiChina Xi’an Maternal and Child Health Hospital 73 West StreetXi’an 710002China

Background The pathogenesis of autism spectrum disorders remains elusive and currently there are no diagnostic or pre-dictive biomarkers in autism available. Proteomic profiling has been used in a wide range of neurodevelopmental disorder studies, which could produce deeper perceptions of the molecular bases behind certain disease and potentially becomes useful in discovering biomarkers in autism spectrum disorders. Methods Serum samples were collected from autistic children about 3 years old in age (n = 32) and healthy controls (n = 20) in similar age and gender. The samples were identified specific proteins that are diff erentially expressed by magnetic bead-based pre-fractionation and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-ToF-MS). Results Eight protein peaks were significantly different in autistic children from the healthy controls (P < 0.0001). The two peaks with the most significant diff erences were 6428 and 7758 Da in size. Conclusion According to diff erences in serum protein profiles between the autistic children and healthy controls, this study identified a set of diff erentially expressed proteins those are significant for further evaluation and might function as biomark-ers in autism.

关键词： Autism Matrix-assisted laser desorption ionization time-of-fl ight mass spectrometry Proteomic profi ling Weak cation-exchange chromatography magnetic beads

丙戊酸镁联合多奈哌齐在治疗老年痴呆中的效果分析

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分子诊断与治疗杂志 2024年第7期16卷 1208-1211页

作者：李旭丹杜颖张士巧马占平衡水市第七人民医院精神科河北衡水053000 衡水市第七人民医院心理一科河北衡水053000

目的分析老年痴呆患者应用丙戊酸镁联合多奈哌齐治疗后其认知功能及血清神经营养因子(BDNF)、铜蓝蛋白(CER)、微小核糖核酸-132(miRNA-132)水平等指标变化情况。方法选取2020年10月至2022年10月衡水市第七人民医院收治的110例老年痴... 详细信息

目的分析老年痴呆患者应用丙戊酸镁联合多奈哌齐治疗后其认知功能及血清神经营养因子(BDNF)、铜蓝蛋白(CER)、微小核糖核酸-132(miRNA-132)水平等指标变化情况。方法选取2020年10月至2022年10月衡水市第七人民医院收治的110例老年痴呆患者作为研究对象,以随机数字表法将其分为试验组和对照组,各55例。对照组给予盐酸多奈哌齐片,试验组在此基础上给予丙戊酸镁片,治疗疗程均为3个月。比较两组认知功能、精神行为症状、炎性因子、神经功能及安全性。结果与治疗前比较,两组治疗3个月后的简明蒙特利尔认知评估量表(MoCA)、简易精神状态检查量表(MMSE)评分、BDNF、CER、miRNA-132水平均升高,试验组高于对照组更高,差异有统计学意义(t=12.322、9.215、20.914、18.728、11.721,P0.05)。结论老年痴呆患者应用丙戊酸镁联合多奈哌齐治疗后其血清BDNF、CER、miRNA-132水平升高,神经功能改善,机体炎症减轻,认知功能及神经行为症状进一步改善,且安全性良好。

关键词：老年痴呆丙戊酸镁多奈哌齐认知功能脑源性神经营养因子铜蓝蛋白微小核糖核酸-132

Edge detection of range images using genetic neural networks

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重庆邮电大学学报：自然科学版 2009年第2期21卷 272-275页

作者： FAN Jian-ying du ying ZHOU Yang WANG Yang Department of Measurement-Control Technology ＆ Instrument Harbin University of Science ＆ TechnologyHarbin 150080 P. R. China

due to the complexity and asymmetrical illumination, the images of object are difficult to be effectively segmented by some routine method. In this paper, a kind of edge detection method based on image features and genetic algorithms neural network for range images was proposed. Fully considering the essential difference between an edge point and a noise point, some characteristic parameters were extracted from range maps as the input nodes of the network in the algorithm. Firstly, a genetic neural network was designed and implemented. The neural network is trained by genetic algorithm, and then genetic neural network algorithm is combined with the virtue of global optimization of genetic algorithm and the virtue of parallel computation of neural network, so that this algorithm is of good global property. The experimental results show that this method can get much faster and more accurate detection results than the classical differential algorithm, and has better anti-noise performance.

关键词：遗传神经网络基于图像检测范围遗传算法边缘检测方法神经网络训练神经网络算法参数提取