Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations

作     者：Jing-yi ZHAO Yang LU Shou-ying DU Xiao SONG Jie BAI Yue WANG 

作者机构：Department of Industrial PharmacySchool of Chinese PharmacyBeijing University of Chinese MedicineBeijing 100102China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2012年第13卷第12期

页      面：990-996页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Project supported by the Key New Drug Creation and Development Programme of China (No. 2009ZX09502-008) the National Natural Science Foundation of China (No. 81073057) the Innovation Team Development Program of Beijing University of Chinese Medicine (No. 2011-CXTD-13) 

主　　题：Borneol Intravenous administration lntranasal administration Oral administration Pharmacokinetics 

摘      要：Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese *** order to understand the blood and brain pharmacokinetics after intravenous,intranasal,or oral administration and to investigate the superiority and feasibility of intranasal administration,a simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the quantification of *** samples and brain were collected from mice at 1,3,5,10,20,30,60,90,and 120 min after intravenous,intranasal,or oral administration of borneol at a dosage of 30.0 mg/*** preparations were carried out by liquid-liquid extraction with an internal standard solution of *** pharmacokinetic parameters were calculated by the software of *** calibration curves were linear in the range of 0.11-84.24 μg/ml and 0.16-63.18 μg/g for borneol in plasma and brain,*** methodological and extraction recoveries were both in the range of 85%-115%.The intra-day and inter-day variabilities for plasma and brain samples were ≤5.00% relative standard deviation (RSD).The absolute bioavailabilities F of intranasal and oral administrations were 90.68% and 42.99%.The relative brain targeted coefficients Re of intranasal and oral administrations were 68.37% and 38.40%.The GC-FID method developed could be applied to determination and pharmacokinetic *** borneol from injection was distributed and metabolized fast without absorption *** borneol from oral administration was distributed more slowly and had the lowest absolute *** administration of borneol was quickly absorbed into the blood and brain,was easy to use and had a greater safety than infection,which makes it worthy of further development as an administration route for encephalopathy treatment.