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Panax quinquefolium saponin Optimizes Energy Homeostasis by Modulating AMPK-Activated Metabolic Pathways in Hypoxia-Reperfusion Induced Cardiomyocytes

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Chinese Journal of Integrative Medicine 2021年第8期27卷 613-620页

作者： YU Yong-hui ZHANG Pei wang Cheng-long LIU Jian-gang LI Peng ZHANG Da-wu Department of Traditional Chinese Medicine China-Japan Friendship HospitalBeijing100029China Graduate Shcool Beijing University of Chinese MedicineBeijing100029China Department of Cardiovascular Disease Mongolian Hospital of Traditional Chinese MedicineWuhaiInner Mongolia Autonomous Region016000China Center for Cardiovascular Diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Objective To investigate the effects and underlying mechanisms of Panax quinquefolium saponin(PQS)on energy deficiency in hypoxia-reperfusion(H/R)induced *** The H/R injury involved hypoxia for 3 h and then reperfusion for 2 *** recruited from neonatal rat ventricular myocytes(NRVMs)were randomly divided into control,H/R,H/R+compound C(C.C),H/R+PQS,and H/R+C.C+PQS *** assay,lactase dehydrogenase(LDH)leakage and early apoptosis rate were evaluated to assess cell *** of high energy phosphate compounds were conducted to detect the energy *** expression levels of adenosine monophosphate-activated protein kinase a(AMPKα),glucose transporter 4(GLUT4),phosphate fructose kinase 2(PFK2),fatty acid translocase/cluster of differentiation 36(FAT/CD36),and acetyl CoA carboxylase 2(ACC2)in the regulatory pathways were measured by Western *** staining of GLUT4 and FAT/CD36 was used to observe the mobilization of metabolic *** PQS(50 mg/L)pretreatment significantly alleviated H/R-induced inhibition of NRVMs viability,up-regulation of LDH leakage,acceleration of early apoptosis,and reduction of energy production(P<0.05).Compared with the H/R group,up-regulated expression of AMPKα,GLUT4,PFK2,FAT/CD36 and ACC2 were observed,and more GLUT4 and FAT/CD36 expressions were detected on the membrane in the H/R+PQS group(P<0.05).These effects of PQS on H/R-induced NRVMs were eliminated in the H/R+C.C+PQS group(P<0.05).Conclusion PQS has prominent advantages in protecting NRVMs from H/R-induced cell damages and energy metabolic disorders,by activation of AMPKα-mediated GLUT4-PFK2 and FAT/CD36-ACC2 pathways.

关键词： Panax quinquefolium saponin Chinese medicine neonatal rat ventricular myocytes hypoxia-reperfusion energy metabolism adenosine monophosphate-activated protein kinaseαpathways

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Syntheses, Crystal Structures and Antibacterial Activities of Two New Methyl 12-Alkylamino-13,14-dinitrodeisopropyl-dehydroabietates

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Chinese Journal of Structural Chemistry 2019年第2期38卷 257-262,167页

作者： CHEN Hao GENG yi wang Shi-Fa GU Wen Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University

The title compounds(5 a and 5 b) were synthesized from dehydroabietic acid and characterized by MS, IR, NMR and elemental analysis. The crystal structure of compound 5 a was determined by single-crystal X-ray diffraction. The compound is of monoclinic system, space group P21 with a = 8.0860(16), b = 14.011(3), c = 9.799(2) ?, β = 106.31(3)?, Z = 2, V = 1065.5(4) ?3, Mr = 431.48, Dc = 1.345 Mg/m3, S = 1.002, μ = 0.099 mm-1, F(000) = 460, the final R = 0.0617 and wR = 0.1532 for 1397 observed reflections(I > 2σ(I)). The preliminary antibacterial assay showed that compound 5 a exhibited considerable inhibitory activity against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus(MRSA) with MIC values of 2～8 μg/mL.

关键词： dehydroabietic acid synthesis crystal structure antibacterial activity

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PnSCR82,a small cysteine-rich secretory protein of Phytophthora nicotianae,can enhance defense responses in plants

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Journal of Integrative Agriculture 2022年第3期21卷 751-761页

作者： wang Ya-di LI Fei ZHANG Xin LIU Ting-li LIANG Wen-xing LI De-long College of Plant Health and Medicine Key Laboratory of Integrated Crop Pest Management of Shandong ProvinceQingdao Agricultural UniversityQingdao 266109P.R.China Hunan Academy of Agricultural Sciences Changsha 410125P.R.China Provincial key laboratory of agrobiology Jiangsu Academy of Agricultural SciencesNanjing 210014P.R.China

A number of plant pathogenic species of Phytophthora are known to produce different classes of secretory proteins during interactions with their *** several small cysteine-rich(SCR)secretory proteins,conserved in oomycete pathogens,have been identified in Phytophthora,their specific involvement in these interactions remains *** this study,an SCR effector encoded by Pn SCR82 in *** was identified and shown to have similarities to *** phytotoxic protein,Pc F(Phytophthora cactorum Fragaria).Agroinfection with potato virus X vector,Pn SCR82,was capable of inducing plant hypersensitive cell death in Nicotiana benthamiana and Solanum ***-time PCR results indicated that transiently expressed Pn SCR82 in *** leaves activated the jasmonate,salicylic acid and ethylene signaling *** expression of Pn SCR82 enhanced plant resisitance to *** summary,our results demonstrated that *** Pn SCR82 elicits defensive responses in *** and may potentially play a significant role in future crop protection programs.

关键词： small cysteine-rich secretory protein defense responses resistance

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Phthalimide and Naphthalimide end-Capped Diketopyrrolopyrrole for Organic Photovoltaic Applications

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Chinese Journal of Chemistry 2017年第9期35卷 1396-1404页

作者： Ming Chen Chenchen Du Xiaolei Ren Maoheng yi Jinduo yi Chufeng Chen Feng Liu Minjie Li Changqi Ma Hongyu wang Department of Chemistry College of Science Shanghai University 99 Shangda Road Shanghai 200444 China Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences 398 Ruo Shui Road SEID SIP Suzhou Jiangsu 215123 China No. 2 High School Affiliated to East China Normal University Zizhu 350 Zifeng Road Minhang District Shanghai 200241 China Department of Physics and Astronomy Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China

Two small molecules named PI-DPP and NI-DPP with a DPP core as the central strong acceptor unit and phthalimide/naphthalimide as the terminal weak acceptor were designed and synthesized. The effects of terminal phthalimide/naphthalimide units on the thermal behavior, optical and electrochemical properties, as well as the photovoltaic performance of these two materials were systematically studied. Cyclic voltammetry revealed that the lowest unoccupied molecular orbitals （LUMO）（- -3.6 eV） of both molecules were intermediate to common electron donor （P3HT） and acceptor （PCBM）. This indicated that PI-DPP and NI-DPP may uniquely serve as electron donor when blended with PCBM, and as electron acceptor when blended with P3HT, where sufficient driving forces between DPPs and PCBM, as well as between P3HT and DPPs should be created for exciton dissociation. Using as electron donor materials, PI-DPP and NI-DPP devices exhibited low power conversion efficiencies （PCEs） of 0.90% and 0.76% by blending with PCBM, respectively. And a preliminary evaluation of the potential of the NI-DPP as electron acceptor material was carried out using P3HT as a donor material, and P3HT：NI-DPP device showed a PCE of 0.6%, with an open circuit voltage （Voc） of 0.7 V, a short circuit current density （Jsc） of 1.91 mA·cm^-2, and a fill factor （FF） of 45%.

关键词： diketopyrrolopyrrole phthalimide naphthalimide organic solar cells non-fullerene acceptor

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Electroluminescence from the InGaN/GaN Superlattices Interlayer of Yellow LEDs with Large V-Pits Grown on Si(111)

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Chinese Physics Letters 2018年第5期35卷 115-118页

作者： Xi-xia Tao Chun-lan Mo Jun-lin Liu Jian-li Zhang Xiao-lan wang Xiao-ming Wu long-quan Xu Jie Ding Guang-xu wang Feng-yi Jiang National Institute of LED on Silicon Substrate Nanchang University Nanchang 330047 Nanchang Yellow Green Lighting Company Limited Nanchang 330047

A blue emission originated from In GaN/GaN superlattice（SL） interlayer is observed in the yellow LEDs with V-pits embedded in the quantum wells（QWs）, revealing that sufficient holes have penetrated through the QWs into SLs far away from the p-type layer. In the V-pits embedded LEDs, hole transport has two paths： via the flat c-plane region or via the sidewalls of V-pits. It is proved that the holes in SLs are injected from the sidewalls of V-pits, and the transportation process is significantly affected by working temperature, current density, and the size of V-pits. Four motion possibilities are discussed when the holes flow via the sidewalls. All these may contribute to a better understanding of hole transport and device design.

关键词： In GaN

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磨损加疲劳载荷下的协同疲劳行为

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摩擦学学报 2015年第1期35卷 59-65页

作者：梁益龙易艳良汪航贵州大学材料科学与冶金工程学院贵州贵阳550025 贵州省材料结构与强度重点实验室贵州贵阳550025

自行研制的摩擦磨损装置与轴向疲劳试验机相互配合,实现GDL-1钢试样在疲劳应力(240~280 MPa)及接触载荷(30 N)作用下摩擦磨损疲劳试验.通过对磨损层厚度的分析,研究试样承受摩擦磨损载荷及拉压疲劳载荷双重作用下的疲劳寿命变化,用SEM... 详细信息

自行研制的摩擦磨损装置与轴向疲劳试验机相互配合,实现GDL-1钢试样在疲劳应力(240~280 MPa)及接触载荷(30 N)作用下摩擦磨损疲劳试验.通过对磨损层厚度的分析,研究试样承受摩擦磨损载荷及拉压疲劳载荷双重作用下的疲劳寿命变化,用SEM扫描电镜观察分析次表层内疲劳裂纹扩展的演变过程,并采用Hertz线弹性理论和Smith接触理论计算分析摩擦表面以下切应力值.结果表明:在磨损疲劳载荷作用下,形变层的流变作用将显著影响疲劳小裂纹扩展方向,渐趋于切应力方向,从而提高试样疲劳寿命.在此基础上,建立了在摩擦磨损疲劳载荷下疲劳裂纹扩展模型.此外,计算可知在距表层深度0.03 mm处切应力最大,0.18 mm以内材料产生塑性变形,导致形变层的形成.

关键词：协同疲劳磨损疲劳载荷形变层流变作用

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Single-cell analysis reveals the lncRNA-MEG3/miRNA-133a-3p/PRRT2 axis regulates skeletal muscle regeneration and myogenesis

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Genes & Diseases 2023年第2期10卷 359-362页

作者： yilong Yao Zishuai wang Yun Chen Lei Liu Liyuan wang Guoqiang yi Yalan Yang Dazhi wang Kui Li Zhonglin Tang Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China Kunpeng Institute of Modern Agriculture at Foshan FoshanGuangdong 528226China Center for Regenerative Medicine University of South Florida Health Heart Institute Morsani College of MedicineUniversity of South FloridaFL 33602USA Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China GuangXi Engineering Centre for Resource Development of Bama Xiang Pig BamaGuangxi 547500China State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

Skeletal muscle is the largest motor and metabolic organ of the body, which has a robust capacity for regeneration following injury or disease. Delayed regeneration after skeletal muscle injury reduces muscle contractility and leads to dysfunction of innervation. Therefore, identifying the regulation components in skeletal muscle regeneration and determining their molecular mechanisms are important to discover novel therapeutic markers for muscular diseases. long non-coding RNA (LncRNA) has been implicated in skeletal muscle regeneration. Recent developed single-cell RNA sequencing (scRNA-seq) provides a higher resolution of cellular differences than bulk RNA-seq. Here, we re-analyzed single-cell transcriptomes data of skeletal muscle regeneration and identified lncRNA maternally expressed gene 3 (lncRNA-MEG3) was highly expressed in muscle satellite cells (MuSCs). Further study showed that lncRNA-MEG3 regulates skeletal muscle regeneration via sponging miR-133a-3p to regulate proline-rich transmembrane protein 2 (PRRT2) expression level. These results suggested that lncRNA-MEG3 might be a potential target for skeletal muscle diseases.

关键词： MEG3 skeletal muscular

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Silicone Chain Extender for Recycled Polyethylene-terephthalate with Higher Flexibility

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Journal of Wuhan University of Technology(Materials Science) 2019年第5期34卷 1228-1232页

作者： wang Li HUANG Ronghua North China University of Water Resources and Electric Power Zhengzhou 450046China School of Power&Mechanical Engineering Wuhan UniversityWuhan 430072China School of Materials Science&Engineering Hubei UniversityWuhan 430062China Engineering Center of New Tobacco Product China Tobacco Hubei Industrial Co LtdWuhan 430040China

To decrease the modulus and increase the mechanical properties of recycled PET by introducing the flexible segments, the recycled polyethylene-terephthalate(PET) was modified by the chain extender produced with 2, 4, 6, 8-tetramethyl-2, 4, 6, 8-tetra(2, 3-epoxypropoxy) propylcyclotetrasiloxane by the hydrosilylation reaction. Different percentages of chain extender were used in order to investigate the effect of chain extender content on the modulus of PET. The dynamic mechanical analysis was performed on PET samples, which showed that Tg of PET was firstly raised by the addition of chain extender and then decreased. Small amplitude shearing test performed on PET samples confirmed that the addition of the flexible segments could remarkably decrease the modulus of PET, which would be helpful for the extrusion process. The entanglements from branches were also influenced by the addition of extender.

关键词： PET chain extender silicone flexibility branches

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The NAC transcription factor CINAC68 positively regulates sugar content and seed development in watermelon by repressing CIINV and CIGH3.6

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Horticulture Research 2021年第1期8卷 3028-3041页

作者： Jinfang wang Yanping wang Jie Zhang yi Ren Maoying Li Shaowei Tian Yongtao Yu yi Zuo Guoyi Gong Haiying Zhang Shaogui Guo Yong Xu National Watermelon and Melon Improvement Center Beijing Academy of Agricultural and Forestry SciencesKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China)Beijing Key Laboratory of Vegetable Germplasm ImprovementBeijing 100097China

NAC(NAM,ATAF1/2,and CUC2)transcription factors play important roles in fruit ripening and *** watermelon genome encodes 80 NAC genes,and 21 of these NAC genes are highly expressed in both the flesh and vascular *** these genes,CINAC68 expression was signi fi cantly higher in flesh than in ***,the intrinsic regulatory mechanism of CINAC68 in fruit ripening and quality is still *** this study,we found that ClNAC68 is a transcriptional repressor and that the repression domain is located in the *** of CINAC68 by the CRISPR-Cas9 system decreased the soluble solid content and sucrose accumulation in mutant *** was delayed,germination was inhibited,and the IAA content was signi ficantly decreased in mutant *** analysis showed that the invertase gene CUNV was the only gene involved in sucrose metabolism that was upregulated in mutant flesh,and expression of the indole-3-acetic acid-amido synthetase gene CIGH3.6 in the IAA signaling pathway was also induced in mutant *** and dual-luciferase assays showed that CINAC68 directly bound to the promoters of CUNV and CIGH3.6 to repress their *** results indicated that CINAC68 positively regulated sugar and IAA accumulation by repressing CUNV and *** findings provide new insights into the regulatory mechanisms by which NAC transcription factors affect fruit quality and seed development.

关键词： expression metabolism inhibited

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Synthesis and CDK2 kinase inhibitory activity of 7/7′-azaindirubin derivatives

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Chinese Chemical Letters 2010年第3期21卷 297-300页

作者： wang, Zhao Hui Dong, ying wang, Tao Shang, Ming Hong Hua, Wei yi Yao, Qi Zheng China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China China Pharmaceut Univ Dept Organ Chem Nanjing 210009 Peoples R China China Pharmaceut Univ Jiangsu Ctr Drug Screening Nanjing 210009 Peoples R China

A series of novel 7 -azaindirubin(1a-g) and 7-azaindirubin(2a,2c,2e and 2f) derivatives were designed and *** structures were characterized by ~1H NMR and MS spectroscopy as well as by elemental *** inhibitory properties against CDK2/cylinA were evaluated in *** contrast to indirubin,some of the described azaindirubins emerged as potent inhibitors of CDK2/cylinA and compound 2b had more potent *** tests also showed that nitrogen atom at 7-position of azaindirubi...

关键词： 7 -Azaindirubin 7-Azaindirubin Synthesis CDK2/cyclinA Inhibition

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