Syntheses, Crystal Structures and Antibacterial Activities of Two New Methyl 12-Alkylamino-13,14-dinitrodeisopropyl-dehydroabietates

作     者：CHEN Hao GENG Yi WANG Shi-Fa GU Wen 陈浩;耿艺;王石发;谷文

作者机构：Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2019年第38卷第2期

页      面：257-262,167页

核心收录：

学科分类：0817[工学-化学工程与技术] 08[工学] 

基　　金：supported by the National Natural Science Foundation of China(31770616) the Natural Science Foundation of Jiangsu Province(BK201516) the Natural Science Foundation for Colleges and Universities in Jiangsu Province(17KJA220002) Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015C221) a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) 

主　　题：dehydroabietic acid synthesis crystal structure antibacterial activity 

摘      要：The title compounds(5 a and 5 b) were synthesized from dehydroabietic acid and characterized by MS, IR, NMR and elemental analysis. The crystal structure of compound 5 a was determined by single-crystal X-ray diffraction. The compound is of monoclinic system, space group P21 with a = 8.0860(16), b = 14.011(3), c = 9.799(2) ?, β = 106.31(3)?, Z = 2, V = 1065.5(4) ?3, Mr = 431.48, Dc = 1.345 Mg/m3, S = 1.002, μ = 0.099 mm-1, F(000) = 460, the final R = 0.0617 and wR = 0.1532 for 1397 observed reflections(I 2σ(I)). The preliminary antibacterial assay showed that compound 5 a exhibited considerable inhibitory activity against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus(MRSA) with MIC values of 2～8 μg/mL.