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Journal of Environmental Science and Engineering(B) 2012年第7期1卷 931-939页

作者： Seung yeon Choi Youngsul jeong Fairmont Preparatory Academy Anaheim 92801 CA USA Department of Natural Sciences Washington Baptist University Annandale 22003 VA USA

The coastal zone is the significant environmental setting where ocean interfaces land. In addition, it is economically important because of its high residential, commercial and recreational values. Meanwhile, in the United States, public coastal areas are increasingly off-limits due to elevated levels of fecal pollution and other contaminants. This study investigates the effects of rainfall, discharge, wave, and alongshore transport on coastal FIB （fecal indicator bacteria） concentrations at adjacent beaches in Orange County, California, over three years＇ period from October 2001 to September 2004. In order to identify the dominant tempora land spatial patterns of fecal pollutions along the coastal beaches, Empirical Orthogonal Function analysis was utilized for the three-year measurements （n = 39,525） of FIB concentration data from 17 sampling stations. Through the data analysis and the empirical orthogonal function analysis, it was found that the dominant factor effecting coastal FIB concentration is precipitation event and consequent water discharge from Santa Ana River in the area. The Empirical Orthogonal Function analysis revealed the potential non-point FIB sources around northern part of Orange County beaches. In addition, this study confirmed the existing alongshore transport by wave-driven surf zone current and offshore tidal currents.

关键词： Fecal pollution coastal water rainfall discharge alongshore transport.

Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

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World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： Ji Won Kim Kook Lae Lee Ji Bong jeong Byeong Gwan Kim Sue Shin Joo Sung Kim Hyun chae Jung In Sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

Tonsil-derived stem cells as a new source of adult stem cells

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World Journal of Stem Cells 2019年第8期11卷 506-518页

作者： Kyung-Ah Cho Hyun Jung Lee Hansaem jeong Miri Kim Soo yeon Jung Hae Sang Park Kyung-Ha Ryu Seung Jin Lee Byeongmoon jeong Hyukjin Lee Han Su Kim Department of Microbiology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 South Korea College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Department of Otorhinolaryngology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Otorhinolaryngology College of Medicine Hallym University Chuncheon 24252 South Korea Department of Pediatrics College of Medicine Ewha Womans University Seoul 07985 South Korea

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

关键词： Stem cell Tonsil-derived stem cell Differentiation Endoderm Mesoderm Ectoderm Cell therapy

Flexible highly-effective energy harvester via crystallographic and computational control of nanointerfacial morphotropic piezoelectric thin film

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Nano Research 2017年第2期10卷 437-455页

作者： Chang Kyu jeong Sung Beom Cho Jae Hyun Han Dae Yong Park Suyoung Yang Kwi-II Park Jungho Ryu Hoon Sohn Yong-chae Chung Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea KAISTInstitute for the NanoCentury (KINC) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea Division of Materials Science and Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seou104763 Republic of Korea Department of Civil and Environmental Engineering KAIST 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea Department of Energy Engineering Gyeongnam National University of Science and Technology 33 Dongjin-ro Jinju Gyeongnam 52725 Republic of Korea Functional Ceramic Group Korea Institute of Materials Science (KIMS) 797 Changwon-daero Seongsan-gu Changwon Gyeongnam.51508 Republic of Korea

Controlling the properties of piezoelectric thin films is a key aspect for designing highly efficient flexible electromechanical devices. In this stud）~ the crystallographic phenomena of PbZr1-xTixO3 （PZT） thin films caused by distinguished interfacial effects are deeply investigated by overlooking views, including not only an experimental demonstration but also ab initio modeling. The polymorphic phase balance and crystallinity, as well as the crystal orientation of PZT thin films at the morphotropic phase boundary （MPB）, can be stably modulated using interfacial crystal structures. Here, interactions with MgO stabilize the PZT crystallographic system well and induce the texturing influences, while the PZT film remains quasi-stable on a conventional A1203 wafer. On the basis of this fundamental understanding, a high-output flexible energy harvester is developed using the controlled-PZT system, which shows significantly higher performance than the unmodified PZT generator. The voltage, current, and power densities are improved by 556%, 503%, and 822%, respectively, in comparison with the previous flexional single-crystalline piezoelectric device. Finally, the improved flexible generator is applied to harvest tiny vibrational energy from a real traffic system, and it is used to operate a commercial electronic unit. These results clearly indicate that atomic-scale designs can produce significant impacts on macroscopic applications.

关键词： energy harvesting morphotropic phaseboundary (MPB) piezoelectric first-principles calculation lead zirconium titanate(PZT)

Hepatic artery pseudoaneurysm caused by acute idiopathic pancreatitis

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World Journal of Gastroenterology 2012年第18期18卷 2291-2294页

作者： yeon Hwa Yu Joo Hyun Sohn Tae Yeob Kim Jae Yoon jeong Dong Soo Han Yong Cheol Jeon Min Young Kim Department of Internal Medicine Hanyang University College of MedicineGuriGyunggi-Do 471-701South Korea Department of Radiology Hanyang University College of MedicineGuri 471-701South Korea

Hepatic artery pseudoaneurysm(HAP) is a very rare disease but in cases of complication,there is a very high *** most common cause of HAP is iatrogenic trauma such as liver biopsy,transhepatic biliary drainage,cholecystectomy and *** may also occur with complications such as infections or inflammation associated with septic *** has been reported rarely in patients with acute *** far as we are aware,there is no report of a case caused by acute idiopathic pancreatitis,*** report a case of HAP caused by acute idiopathic pancreatitis which developed in a 61-year-old *** woman initially presented with acute pancreatitis due to unknown *** conservative management,her symptoms seemed to have *** eight days after admission,abdominal pain abruptly became worse *** computed tomography(CT) was rechecked and it detected a new HAP that was not seen in a previous abdominal *** retrograde cholangiopancreatography(ERCP) was performed because of a suspicion of hemobilia as a cause of aggravated abdominal *** confirmed hemobilia by observing fresh blood clots at the opening of the ampulla and several filling defects in the distal common bile duct on *** any particular treatment such as embolization or surgical ligation,HAP thrombosed *** months after discharge,abdominal CT demonstrated that HAP in the left lateral segment had disappeared.

关键词： Hepatic artery Pseudoaneurysm Pancreatitis Acute Hemobilia

Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells

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Acta Pharmacologica Sinica 2004年第10期 132-139页

作者： Han-jung chae,Kyung-mi PARK,Geun-youn LEE,Gi-seup jeong,Hyung-rae PARK,Hyung-min KIM,Soo-wan chae,Shim-keun YOO,Hyung-ryong KIM Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea Department of Pharmacology College of Oriental Medicine Kyung Hee University Seoul South Korea Department of Pharmacology and the Institute of Cardiovascular Research School of Medicine Chonbuk National University Jeonju Chonbuk 464-701 South Korea Department of Gynecology School of Oriental Medicine Wonkwang University Iksan Chonbuk 470-739 South Korea Department of Dental Pharmacology and Nano-Science & Technology Research Institute School of Dentistry Wonkwang University Iksan Chonbuk 570-749 South Korea

AIM: To study the mechanism of Je-Chun-Jun (JCJ)-inducing the apoptosis of the human cervical carcinoma, HeLa cells. METHODS: The cell viability was assessed using MTT assay. The optical density was measured at 570 nm. The caspase activity was measured using 50 mmol/L of fluorogenic substrate, AC-DEVD-AMC (caspase-3), AC-VEID-AMC (caspase-8) or AC-LEHD-AFC (caspase-9). To confirm the expression of proteins, Western blotting was performed. To detect the characteristic of apoptosis chromatin condensation, HeLa cells were stained with Hoechst 33258 in the presence of JCJ. For the cell cycle analysis, HeLa cells were incubated with Propidium iodide (PI) solution. Fluorescence intensity of cell cycle was measured using flow cytometry system. RESULTS: The loss of viability occurred following the exposure of 10 g/L JCJ. Cells treated with 10 g/L JCJ for 3 d exhibited the apoptotic morphology (brightly blue-fluorescent condensed nuclei by Hoechst 33258-staining) and the reduction of cell volume. Cells incubated

关键词： herbal medicine apoptosis p38 MAPK HeLa cells

Electrochemical and structural evolution of structured V_(2)O_(5) microspheres during Li-ion intercalation

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Journal of Energy Chemistry 2021年第4期30卷 108-113页

作者： Sul Ki Park Puritut Nakhanivej jeong Seok yeon Kang Ho Shin Wesley M.Dose Michael De Voider Jin Bae Lee Hae Jin Kim Ho Seok Park School of Chemical Engineering Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea Institute for Manufacturing Department of EngineeringUniversity of CambridgeCambridge CB30FSUnited Kingdom Department of Chemistry University of CambridgeLensfield RoadCambridge CB21EWUnited Kingdom Research Center for Materials Analysis Korea Basic Science InstituteDaejeonRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University2066SeoburoJangan-guSuwon440-746South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

With the development of stable alkali metal anodes,V_(2)O_(5) is gaining traction as a cathode material due to its high theoretical capacity and the ability to intercalate Li,Na and K ***,we report a method for synthesizing structured orthorhombic V_(2)O_(5) microspheres and investigate Li intercalation/deintercalation into this *** industry adoption,the electrochemical behavior of V_(2)O_(5) as well as structural and phase transformation attributing to Li intercalation reaction must be further *** synthesized V_(2)O_(5) microspheres consisted of small primary particles that were strongly joined together and exhibited good cycle stability and rate capability,triggered by reversible volume change and rapid Li ion *** addition,the reversibility of phase transformation(a,e,d,c and xLixV_(2)O_(5))and valence state evolution(5+,4+,and 3.5+)during intercalation/de-intercalation were studied via in-situ X-ray powder diffraction and X-ray absorption near edge structure analyses.

关键词： Lithium ion batteries Vanadium pentoxide(V2O5) In-situ analysis Phase transformation Intercalation/de-intercalation

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How to improve patient satisfaction during midazolam sedation for gastrointestinal endoscopy?

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World Journal of Gastroenterology 2017年第6期23卷 1098-1105页

作者： Eun Hyo Jin Kyoung Sup Hong Young Lee Ji yeon Seo Ji Min Choi Jaeyoung Chun Sang Gyun Kim Joo Sung Kim Hyun chae Jung Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam Center Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Department of Biostatistics and Bioinformatics Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam Center

To determine the procedure-related factors that affect sedation satisfaction and to make a suggestion to improve *** prospectively enrolled a total of 456 patients who underwent outpatient endoscopy procedures with midazolam sedation between March 2014 and August 2014. All patients completed both pre- and post-endoscopy questionnaires about sedation expectations and *** study cohort included 167 (36.6%) patients who underwent esophagogastroduodenoscopy (EGD), 167 (36.6%) who underwent colonoscopy, and 122 (26.8%) who underwent a combined procedure (EGD and colonoscopy). Over 80% of all patients were satisfied with sedation using midazolam. In univariate and multivariate analyses, total procedure time in the EGD group, younger age (≤ 50 years), and longer colonoscopy withdrawal time in the colonoscopy group were related to decreased satisfaction with sedation. However, in active monitoring and intervention group, there was no decrease in grade of satisfaction despite longer procedure time due to more procedures during colonoscopy. Younger age (≤ 50 years), longer inter-procedure time gap, and colonoscopy withdrawal time were related to decreased satisfaction in the combined EGD and colonoscopy *** is still a safe and effective sedative for gastrointestinal endoscopy. Satisfaction with sedation depends on several factors including age (≤ 50 years) and procedure time duration. To improve patient satisfaction with sedation, active monitoring of sedation status by the endoscopist should be considered for patients who require long procedure time.

关键词： Conscious sedation Patient satisfaction Endoscopy Midazolam Surveys and questionnaires

Sojucktang induces apoptosis via loss of mitochondrial membrane potential and caspase-3 activation in KLE human endometrial cancer cells

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Chinese Science Bulletin 2009年第23期54卷 4387-4392页

作者： OH yeon-Suk KWON Hee-Young jeong Soo-Jin PARK Ki-Young KIM Sun-Young LEE Hyo-Jung LEE Hyo-jeong LEE Eun-Ok AHN Kwang Seok KIM Sung-Hoon Cancer Preventive Material Development Research Center Oriental Medical CollegeKyunghee University College of Medicine Kyunghee University

Sojucktang (SJT) has long been used for the treatment of endometrial diseases in Korea. However, the mechanisms responsible for the SJT-induced apoptosis in endometrial cancer cells remain unclear. In the present study, SJT was demonstrated to show cytotoxic effect and induce apoptotic cell death via mitochondrial regulation in KLE endometrial cancer cells. Linderae Radix, Glycyrrhizae Radix, Zedoariae Rhizoma, Trogopterorum Faeces and Agelicae Gigantis Radix were found to be the potent constituent herbs of SJT to significantly decrease the viability of KLE cells by a tetra zolium salt (XTT) assay. Apoptotic bodies were observed in SJT-treated KLE cells by 4′-6-diamidino-2-phenylindole (DAPI) and TdT-mediated-dUTP nick-end labeling (TUNEL) assay. SJT also increased sub-G1 DNA contents of the cell cycle undergoing apoptosis in a dose-dependent manner. Furthermore, it was observed that SJT activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), and decreased mitochondrial membrane potential in a dose-dependent manner. Taken together, this study shows that SJT exerts anti-tumor activity against KLE endometrial cancer cells via mitochondrial dependent apoptosis induction.

关键词：线粒体膜电位 caspase 子宫内膜癌细胞凋亡活化癌细胞诱导细胞毒作用

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Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung Lee jeong Hyun Yoon Young-Woong Song Seok Daniel Namgung Taehoon Sung Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

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