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Embolization combined with endoscopic variceal ligation for the treatment of esophagogastric variceal bleeding in patients with cirrhosis

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Chinese Medical Journal 2007年第1期120卷 36-40页

作者： HUANG Liu-ye CUI jun wu Cheng-rong LIU Yun-xiang Department of Gastroenterology Yuhuangding Hospital MedicalCollege of Qingdao University Yantai 264000 China

Background Esophagogastric variceal bleeding caused by cirrhosis is a kind of emergent condition in the clinic. This study was conducted to explore the therapeutic effect and superiority of embolization of gastric fundus vadces combined with endoscopic variceal ligation （EVL） of esophageal varices for the treatment of patients with esophagogastric variceal bleeding caused by cirrhosis. Methods Totally 172 patients were diagnosed by endoscopic examination within 24 hours of hospitalization with active gastric fundus variceal bleeding and grade II above esophageal varices caused by cirrhosis. Other causes leading to upper digestive tract bleeding were excluded. Patients were randomly divided into a control group （n=82） and a therapy group （n=-90） following a random number table method. For the former, embolization for gastric fundus varices was performed, then an EVL for esophageal varices was performed 2 months later. For the therapy group, embolization for gastric fundus varices and EVL for esophageal varices were performed at the same time. Results The rate of emergency hemostasis in the therapy group was 100.0%, higher than that in the control group （87.8%, P〈0.05）. The rate of early rebleeding in the therapy group was 6.7% while the rate in the control group was 23.6% （P〈0.05）. No complications related to treatment occurred in both groups. Conclusion Embolization for gastric fundus varices combined with EVL for esophageal varices is a safe and effective method for the treatment of patients with esophagogastric variceal bleeding caused by cirrhosis.

关键词： esophagogastric varices embolization endoscopic variceal ligation cirrhosis

Narrow-band imaging in the diagnosis of early esophageal cancer and precancerous lesions

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Chinese Medical Journal 2009年第7期122卷 776-780页

作者： HUANG Liu-ye CUI jun wu Cheng-rong LIU Yun-xiang XU Ning Department of Gastroenterology Yantai Yuhuangding HospitalAffiliated to Medical College of Qingdao University YantaiShandong 264000 China

Background In the recent years, the incidence of esophageal cancer in China has increased. The key point for raising the survival rate is the diagnosis and treatment at an early stage. Narrow-band imaging （NBI） can enhance the contrast of the mucous membrane of the esophagus without staining. This study aimed to explore the value of NBI in the diagnosis of early esophageal cancer and precancerous lesions. Methods The esophagus was examined with ordinary endoscopy and NBI endoscopy. Pit patterns and blood capillary forms were examined with routine magnifying endoscopy and NBI endoscopy. Finally, a 1.2% Lugoul＇s iodine solution was used to stain the esophageal mucosal surface and a biopsy was taken at all the sites where NBI or iodine staining was positive. NBI and iodine staining scales were compared with pathologic diagnosis, which was considered as the gold standard. Results A total of 90 cases （138 lesions in total） were diagnosed as early esophageal cancer or precancerous lesions; 104 lesions （75.4%） were detected with ordinary endoscopy, 120 lesions （87.0%） were detected with NBI endoscopy, and 138 lesions （100%） were detected with iodine staining. The lesion detection rate of NBI was significantly lower than that of iodine staining （X2=17.176, P 〈0.01）. However, there was no significant difference between NBI and iodine staining for the diagnosis of high grade intraepithelial neoplasia （X2=1.362, P 〉0.05）, while the detection rate of NBI was significantly lower than that of iodine staining for the diagnosis of low grade intraepithelial neoplasia （X2=13.388, P 〈0.01）. The pit pattern and blood capillary form of early esophageal cancer and precancerous lesions could be demonstrated clearer with NBI than with ordinary endoscopy. Conclusions NBI can enhance the contrast of the mucous membrane of the esophagus without staining. The combination of NBI and iodine staining can raise the diagnostic rate of early esophageal cancer and precancerous lesions.

关键词： esophageal neoplasms endoscopy narrow-band imaging

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun ye-jun wu Qiu-Sha Huang Hai-Xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang Xiao-jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-Jian wu Ying Cheng Xiao-jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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再谈翻译中的等效问题

南京工程学院学报 2002年第4期2卷 44-47页

作者：叶君武南京工程学院外语部江苏南京210013

长期以来 ,翻译的等效问题一直是人们争论的焦点。在翻译中 ,怎样才能达到完美 ,等效呢 ?针对这一问题 ,不同时期的译者们都提出了自己的观点和看法 ,但迄今为止还无定论。文章试图从翻译学的角度来对这一问题作些探讨。文中介绍了几种... 详细信息

长期以来 ,翻译的等效问题一直是人们争论的焦点。在翻译中 ,怎样才能达到完美 ,等效呢 ?针对这一问题 ,不同时期的译者们都提出了自己的观点和看法 ,但迄今为止还无定论。文章试图从翻译学的角度来对这一问题作些探讨。文中介绍了几种不同的翻译观对翻译等效问题的不同看法。

关键词：等效翻译观解构建构翻译学翻译方法语言差异文化背景

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口译中言说者语言的真诚性问题

安徽工业大学学报（社会科学版） 2010年第3期27卷 72-73页

作者：叶君武南京工程学院外语系江苏南京211167

口译是一种社会交流活动,它是对说话者原语的一种诠释。口译者应遵循自然规律,把握说话者的主旨,选择合适的表达方式,以解决言说者语言的真诚性问题。

关键词：交往行为理论口译真诚性

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论汉英翻译中动静态场景对比问题的处理

南京工程学院学报（社会科学版） 2010年第2期10卷 35-38页

作者：叶君武南京工程学院外语系江苏南京211167

在汉英翻译实践中,译者往往难以掌握如何在译文中体现原文中场景的动静态对比问题。译者根据对原文的理解从认知语言学的事件域概念出发,对各个事件域进行合理的切分,分析汉语文本中动作事件间的主次性,并且利用事件化和去事件化的方法... 详细信息

在汉英翻译实践中,译者往往难以掌握如何在译文中体现原文中场景的动静态对比问题。译者根据对原文的理解从认知语言学的事件域概念出发,对各个事件域进行合理的切分,分析汉语文本中动作事件间的主次性,并且利用事件化和去事件化的方法在译文中凸显这种主次性,从而充分地表现出原文动静态层次的对比性,能提高译文的质量。

关键词：汉英翻译事件域动静态主次性

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基于实景分析法的大学英语语音教学初探

中国西部科技 2011年第6期10卷 80-82页

作者：叶君武南京工程学院外语系江苏南京211167

在大学英语语音教学中,教师面临着因缺乏实证性材料而教学效果不佳的问题,而发音的强弱读式、音调和重音模式更是教学的难点。教师可通过实景分析的方法,在语音学习的难点方面给学生进行分析和讲解,以取得良好的教学效果。

关键词：语音教学强弱读式音调重音模式