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Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

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Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen yao Xin Liu Yan Gao Hailin Cong Bing Yu Youqing shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

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An efficient numerical shape analysis for light weight membrane structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第4期15卷 255-271页

作者： Chao YANG Yan-bin shen yao-zhi LUO Space Structures Research Center Zhejiang University Hangzhou 310058 China

The determination of initial equilibrium shapes is a common problem in research work and engineering applications related to membrane structures. Using a general structural analysis framework of the finite particle method （FPM）, this paper presents the first application of the FPM and a recently-developed membrane model to the shape analysis of light weight mem- branes. The FPM is rooted in vector mechanics and physical viewpoints. It discretizes the analyzed domain into a group of parti- cles linked by elements, and the motion of the free particles is directly described by Newton＇s second law while the constrained ones follow the prescribed paths. An efficient physical modeling procedure of handling geometric nonlinearity has been developed to evaluate the particle interaction forces. To achieve the equilibrium shape as fast as possible, an integral-form, explicit time integration scheme has been proposed for solving the equation of motion. The equilibrium shape can be obtained naturally without nonlinear iterative correction and global stiffness matrix integration. Two classical curved surfaces of tension membranes pro- duced under the uniform-stress condition are presented to verify the accuracy and efficiency of the proposed method.

关键词： Tension membranes Finite particle method (FPM) Shape analysis Explicit time integration Initial equilibriumshape

Targeting neuroinflammation in Alzheimer's disease:from mechanisms to clinical applications

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Neural Regeneration Research 2023年第4期18卷 708-715页

作者： Zi-Zhen Si Chen-Jun Zou Xi Mei Xiao-Fang Li Hu Luo yao shen Jun Hu Xing-Xing Li Lun Wu Yu Liu Pharmacy Department The Affiliated Hospital of Medical SchoolNingbo UniversityNingboZhejiang ProvinceChina Department of Physiology and Pharmacology School of MedicineNingbo UniversityNingboZhejiang ProvinceChina Department of Geriatric Psychiatry Ningbo Kangning HospitalNingboZhejiang ProvinceChina Key Laboratory Office of Sleep Medicine Ningbo Kangning HospitalNingboZhejiang ProvinceChina Department of Psychology Collage of Teacher EducationNingbo UniversityNingboZhejiang ProvinceChina Department of Preventive Medicine School of MedicineNingbo UniversityNingboZhejiang ProvinceChina

Alzheimer’s disease is characterized by sustained neuroinflammation leading to memory loss and cognitive *** past decade has witnessed tremendous efforts in Alzheimer’s disease research;however,no effective treatment is available to prevent disease *** increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer’s disease pathogenesis,alongside the classical pathological hallmarks such as misfolded and aggregated proteins(e.g.,amyloid-beta and tau).Firstly,this review summarized the clinical and pathological characteristics of Alzheimer’s ***,we outlined key aspects of glial cell-associated inflammation in Alzheimer’s disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer’s disease ***,we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer’s *** addition,the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer’s disease were also discussed through these *** the final section,the remaining key problems according to the current research status were discussed.

关键词： Alzheimer’s disease astrocytes immune signaling inflammatory cytokines microglia neuroinflammation neurotoxicity therapeutic strategies

Research on the navigation method of large-scale differential tail-control improvised guided munitions based on rotational speed constraints

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Defence Technology（防务技术） 2024年第8期38卷 155-170页

作者： Ning Liu Wenjiang Zhao yao Wang Kai shen Zhong Su Wenhao Qi Yuedong Xie Beijing Key Laboratory of High Dynamic Navigation Technology Beijing Information Science and Technology UniversityBeijing100192China Hua an Industry Group Co. Ltd.Qiqihar161006China Integrated Navigation and Intelligent Navigation Laboratory Beijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Beijing100081China

In the process of launching guided projectile under the conventional system, it is difficult to effectively obtain the precise navigation parameters of the projectile in the high dynamic environment. Aiming at this problem, this paper describes a new system of guided ammunition based on tail spin reduction. After analyzing the mechanism of the ammunition's tail spin reduction, a navigation method of large scale difference tail control simple guided ammunition based on speed constraint is proposed. In this method,the corresponding navigation constraints can be carried out by combining the rotation speed state of the ammunition itself, and the optimal solution of navigation parameters during the flight of the missile can be obtained by Extended Kalman Filter(EKF). Finally, the performance of the proposed method was verified by the simulation environment, and the hardware-in-the-loop simulation test and flight test were carried out to verify the performance of the method in the real environment. The experimental results show that the proposed method can achieve the optimal estimation of navigation parameters for simple guided ammunition with large-scale difference tail control. Under the conditions of simulation test and hardware-in-loop simulation test, the position and velocity errors calculated by the method in this paper converged. Under the condition of flight test, the spatial average error calculated by the method described in this paper is 6.17 m, and the spatial error of the final landing point is 3.50 *** this method, the accurate acquisition of navigation parameters in the process of projectile launching is effectively realized.

关键词： Guided projectiles Tail spin reduction RPM constraints Combined navigation Extended Kalman filter(EKF)

Spatial and Temporal Distribution Characteristics of Solar Energy Resources in Tibet

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Energy Engineering 2024年第1期121卷 43-57页

作者： Yanbo shen Yang Gao Yueming Hu Xin yao Wenzheng Yu Yubing Zhang Public Meteorological Service Center China Meteorological AdministrationBeijing100081China Center forWind and Solar Energy Resources China Meteorological AdministrationBeijing100081China School of Applied Meteorology Nanjing University of Information Science&TechnologyNanjing210044China School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjing210044China

The Tibet Plateau is one of the regions with the richest solar energy resources in the *** the process of achieving carbon neutrality in China,the development and utilization of solar energy resources in the region will play an important *** this study,the gridded solar resource data with 1km resolution in Tibet were obtained by spatial correction and downscaling of SMARTS *** this basis,the spatial and temporal distribution characteristics of solar energy resources in the region in the past 30 years(1991–2020)are finely evaluated,and the annual global horizontal radiation resource is *** results show that:1)The average annual global horizontal radiation amount in Tibet is 1816 kWh/m^(2).More than 60%of the area belongs to the“Most abundant”(GHI≥1750 kWh/m^(2))area of China’s solar energy resources category A,and nearly 40%belongs to the“Quite abundant”(1400≤GHI<1750)area of China’s solar energy resource category B.2)In space,the solar energy resources in Tibet increased gradually from north to south and from east to ***,Central and Eastern Shigatse,Shannan,and Southwestern Ali are the most abundant cities,with a maximum annual radiation level of 2189 kWh/m2.3)In terms of time,the total horizontal radiation in Tibet was the highest in May and the lowest in December.74%of the total area belongs to the“Very stable”(R_(w)≥0.47)area of solar resource stability category A,and 26%belongs to the“stable”(0.36≤R_(w)<0.47)area of solar resource stability category *** energy resources in the region show the characteristics of both strong and *** solar energy resources in the region have shown a fluctuating downward trend over the past 30 years,with an average decline of about 12.86(kWh/m2)per decade.4)In terms of solar radiation resources reaching the earth’s surface,the theoretical total amount of annual horizontal radiation in Tibet is about 240.07 billion tons of standard coal or 222.91 billion kilowatts on average.

关键词： Tibet solar resource spatiotemporal distribution

Frustrated Magnetic Interactions and Quenched Spin Fluctuations in CrAs

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Chinese Physics Letters 2022年第12期39卷 89-93页

作者： Yayuan Qin yao shen Yiqing Hao Hongliang Wo Shoudong shen Russell A.Ewings Yang Zhao Leland W.Harriger Jeffrey W.Lynn Jun Zhao State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Shanghai Qizhi Institute Shanghai 200232China ISIS Pulsed Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell CampusDidcotOxonOX110QXUnited Kingdom NIST Center for Neutron Research National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Institute of Nanoelectronics and Quantum Computing Fudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China

The discovery of pressure-induced superconductivity in helimagnets(CrAs,MnP)has attracted considerable interest in understanding the relationship between complex magnetism and unconventional ***,the nature of the magnetism and magnetic interactions that drive the unusual double-helical magnetic order in these materials remains ***,we report neutron scattering measurements of magnetic excitations in CrAs single crystals at ambient *** experiments reveal well defined spin wave excitations up to about 150 meV with a pseudogap below 7 meV,which can be effectively described by the Heisenberg model with nearest neighbor exchange *** surprisingly,the spin excitations are largely quenched above the Néel temperature,in contrast to cuprates and iron pnictides where the spectral weight is mostly preserved in the paramagnetic *** results suggest that the helimagnetic order is driven by strongly frustrated exchange interactions,and that CrAs is at the verge of itinerant and correlation-induced localized states,which is therefore highly pressure-tunable and favorable for superconductivity.

关键词： excitation exchange pressure

Dynamic modeling of cavitation bubble clusters:Effects of evaporation,condensation,and bubble-bubble interaction

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Chinese Physics B 2024年第4期33卷 527-535页

作者：许龙姚昕锐沈阳 College of Science China Jiliang UniversityHangzhou 310018China

We present a dynamic model of cavitation bubbles in a cluster,in which the effects of evaporation,condensation,and bubble-bubble interactions are taken into *** different ultrasound conditions,we examine how the dynamics of cavitation bubbles are affected by several factors,such as the locations of the bubbles,the ambient radius,and the number of *** the variations of bubble radius,energy,temperature,pressure,and the quantity of vapor molecules are *** findings reveal that bubble-bubble interactions can restrict the expansion of bubbles,reduce the exchange of energy among vapor molecules,and diminish the maximum internal temperature and pressure when *** ambient radius of bubbles can influence the intensities of their oscillations,with clusters comprised of smaller bubbles creating optimal conditions for generating high-temperature and high-pressure ***,an increase in the number of bubbles can further inhibit cavitation *** frequency,pressure and waveform of the driving wave can also exert a significant influence on cavitation activities,with rectangular waves enhancing and triangular waves weakening the cavitation of bubbles in the *** results provide a theoretical basis for understanding the dynamics of cavitation bubbles in a bubble cluster,and the factors that affect their behaviors.

关键词： bubble dynamics bubble-bubble interaction mass exchange ultrasound waveform

Automatic traceability link recovery via active learning

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Frontiers of Information Technology & Electronic Engineering 2020年第8期21卷 1217-1225页

作者： Tian-bao DU Guo-hua shen Zhi-qiu HUANG yao-shen YU De-xiang WU College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210093China Key Laboratory of Safety-Critical Software Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Traceability link recovery(TLR)is an important and costly software task that requires humans establish relationships between source and target artifact sets within the same *** research has proposed to establish traceability links by machine learning ***,current machine learning approaches cannot be well applied to projects without traceability information(links),because training an effective predictive model requires humans label too many traceability *** save manpower,we propose a new TLR approach based on active learning(AL),which is called the AL-based *** evaluate the AL-based approach on seven commonly used traceability datasets and compare it with an information retrieval based approach and a state-ofthe-art machine learning *** results indicate that the AL-based approach outperforms the other two approaches in terms of F-score.

关键词： Automatic Traceability link recovery Manpower Active learning

Sarcomatoid intrahepatic cholangiocarcinoma with good patient prognosis after treatment with Huaier granules following hepatectomy:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2829-2835页

作者： Ji-Ye Feng Xian-Peng Li Zong-Yang Wu Li-Ping Ying Chang Xin Zhen-Zhen Dai yao shen Yi-Feng Wu Department of Hepatobiliary&Pancreas Surgery The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Infectious Disease The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Pathology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Radiology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina

BACKGROUND Sarcomatoid intrahepatic cholangiocarcinoma(SICC)is an extremely rare and highly invasive malignant tumor of the *** precise pathologic mechanism of SICC has not been clearly identified,and the prognosis is very *** effectiveness of the treatment strategy of radical hepatectomy combined with Huaier granules has not yet been *** SUMMARY The patient was a 69-year-old male who presented with intermittent right upper abdominal pain for one month and 4-pound weight loss before *** magnetic resonance imaging and magnetic resonance cholangiopancreatography showed multiple stones in the bile ducts accompanied by dilatation of the intrahepatic and extrahepatic bile *** preoperative diagnoses were right intrahepatic bile duct stones and extrahepatic bile duct stones;thus,surgical resection was *** showed that the bile duct wall of the right anterior lobe was thickened,and a mass was visible in the ***,a biopsy was performed,and rapid frozen-section biopsy analysis indicated that the tumor was *** final diagnosis was SICC(T1a N0M0).Huaier granules were taken by the patient as anticancer therapy after *** patient attended follow-up for 72 mo with no tumor recurrence or *** Sarcomatous intrahepatic cholangiocarcinoma is an extremely rare,aggressive malignancy,and the diagnostic gold standard is pathological *** reported the first case of successful treatment with Huaier granules as anticancer therapy after surgery,which indicated that Huaier granules are safe and *** studies are needed to study the anticancer molecular mechanisms of Huaier granules in sarcomatous intrahepatic cholangiocarcinoma.

关键词： Sarcomatous intrahepatic cholangiocarcinoma Hepatectomy Huaier granules Diagnose Therapy Case report