Targeting neuroinflammation in Alzheimer's disease:from mechanisms to clinical applications

作     者：Zi-Zhen Si Chen-Jun Zou Xi Mei Xiao-Fang Li Hu Luo Yao Shen Jun Hu Xing-Xing Li Lun Wu Yu Liu Zi-Zhen Si;Chen-Jun Zou;Xi Mei;Xiao-Fang Li;Hu Luo;Yao Shen;Jun Hu;Xing-Xing Li;Lun Wu;Yu Liu

作者机构：Pharmacy DepartmentThe Affiliated Hospital of Medical SchoolNingbo UniversityNingboZhejiang ProvinceChina Department of Physiology and PharmacologySchool of MedicineNingbo UniversityNingboZhejiang ProvinceChina Department of Geriatric PsychiatryNingbo Kangning HospitalNingboZhejiang ProvinceChina Key Laboratory Office of Sleep MedicineNingbo Kangning HospitalNingboZhejiang ProvinceChina Department of PsychologyCollage of Teacher EducationNingbo UniversityNingboZhejiang ProvinceChina Department of Preventive MedicineSchool of MedicineNingbo UniversityNingboZhejiang ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第4期

页      面：708-715页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81971247(to YL) Zhejiang Provincial Key R&D Plan 2020,No.2020C03064(to YL) Ningbo R&D Plan,No.20181ZDYF020172(to YL) National Social Science Foundation Key Programs,No.18ZDA215(to YL) the Natural Science Foundation of Zhejiang Province,No.LQ22H310001(to ZZS) the Natural Science Foundation of Ningbo,No.2021J101(to ZZS) Regular Scientific Research Project of Education Department of Zhejiang Province,No.Y202146346(to ZZS) 

主　　题：Alzheimer’s disease astrocytes immune signaling inflammatory cytokines microglia neuroinflammation neurotoxicity therapeutic strategies 

摘      要：Alzheimer’s disease is characterized by sustained neuroinflammation leading to memory loss and cognitive *** past decade has witnessed tremendous efforts in Alzheimer’s disease research;however,no effective treatment is available to prevent disease *** increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer’s disease pathogenesis,alongside the classical pathological hallmarks such as misfolded and aggregated proteins(e.g.,amyloid-beta and tau).Firstly,this review summarized the clinical and pathological characteristics of Alzheimer’s ***,we outlined key aspects of glial cell-associated inflammation in Alzheimer’s disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer’s disease ***,we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer’s *** addition,the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer’s disease were also discussed through these *** the final section,the remaining key problems according to the current research status were discussed.