Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

作     者：Dayang Wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao Hailin Cong Bing Yu Youqing Shen 

作者机构：College of Chemistry and Chemical EngineeringCollege of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao266071China School of Materials Science and EngineeringShandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of EducationCenter for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第6期

页      面：1881-1903页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(21874078,22074072,22274083) the Shandong Provincial Natural Science Foundation(ZR2022LZY022,ZR2023LZY005) the Science and Technology Planing Project of South District of Qingdao City(2022-4-005-YY) the Exploration project of the State Key Laboratory of BioFibers and EcoTextiles of Qingdao University(TSKT202101) the High Level Discipline Project of Shandong Province 

主　　题：polysaccharide hydrophobic modification micelle drug delivery biomedicine 

摘      要：Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.