Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine
作者机构:College of Chemistry and Chemical EngineeringCollege of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao266071China School of Materials Science and EngineeringShandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of EducationCenter for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China
出 版 物:《Science China Chemistry》 (中国科学(化学英文版))
年 卷 期:2024年第67卷第6期
页 面:1881-1903页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学]
基 金:supported by the National Natural Science Foundation of China(21874078,22074072,22274083) the Shandong Provincial Natural Science Foundation(ZR2022LZY022,ZR2023LZY005) the Science and Technology Planing Project of South District of Qingdao City(2022-4-005-YY) the Exploration project of the State Key Laboratory of BioFibers and EcoTextiles of Qingdao University(TSKT202101) the High Level Discipline Project of Shandong Province
主 题:polysaccharide hydrophobic modification micelle drug delivery biomedicine
摘 要:Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.