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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： yanxi li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Preparation of layered oxide li(Co_(1/3)Ni_(1/3)Mn_(1/3))O_2 via the sol-gel process

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Rare Metals 2008年第2期27卷 158-164页

作者： ZHANG Wen liU Hanxing HU Chen ZHU Xianjun li yanxi State Key Laboratory of Advanced Technology for Material Synthesis and Processing Wuhan University of Technology Wuhan 430070 China

To obtain homogenous layered oxide li（Co1/3Ni1/3Mn1/3）O2 as a lithium insertion positive electrode material, the sol-gel process using citric acid as a chelating agent was applied. The material li（Co1/3Ni1/3Mn1/3）O2 was synthesized at different calcination temperatures. XRD experiment indicated that the layered li（Co1/3Ni1/3Mn1/3）O2 material could be synthesized at a lower temperature of 800℃, and the oxidation state of Co, Ni, and Mn in the cathode confirmed by XPS were ＋3, ＋2, and ＋4, respectively. SEM observations showed that the synthesized material could form homogenous particle morphology with the particle size of about 200 nm. In spite of different calcination temperatures, the charge-discharge curves of all the samples for the initial cycle were similar, and the cathode synthesized at 900℃ showed a small irreversible capacity loss of 11.24% and a high discharge capacity of 212.2 mAh·g^-1 in the voltage range of 2.9-4.6 V.

关键词： lithium-ion battery layered transition metal oxide sol-gel process high capacity

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Mesoscopic investigation on seismic performance of corroded reinforced concrete columns

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Earthquake Engineering and Engineering Vibration 2022年第4期21卷 969-985页

作者： Jin liu li yanxi Zhang Renbo Du Xiuli Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100024China

In addition to the normal service loadings,engineering structures may be subjected to occasional loadings such as earthquakes,which may cause severe *** the steel rebar is corroded,the damage could be more *** investigate the seismic performance of corroded RC columns,a three-dimensional mesoscale finite element model was *** this approach,concrete was considered as a three-phase composite composed of aggregate,mortar matrix and interfacial transition zone(ITZ).The nonlinear spring were used to describe the bond slip between steel and *** degradation of the material properties of the steel rebar and cover concrete as well as the bonding performance due to corrosion were taken into *** rationality of the developed numerical analysis model was verified by the good agreement between the numerical results and the available experimental *** this basis,the effect of corrosion level,axial force ratio and shear-span ratio on the seismic performance of corroded RC columns,including lateral bearing capacity,ductility,and energy consumption,were explored and *** simulation results indicate that the mesoscopic method can consider the heterogeneity of concrete,to more realistically and reasonably reflect the destruction process of structures.

关键词： reinforcement corrosion reinforced concrete column meso-scale finite element analysis seismic behavior

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Deformation behavior and microstructure evolution of titanium alloys with lamellar microstructure in hot working process: A review

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Journal of Materials Science & Technology 2020年第4期39卷 56-73页

作者： Pengfei Gao Mingwang Fu Mei Zhan Zhenni Lei yanxi li State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of High-Performance Precision Forming Technology and EquipmentSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityP.O.Box 542Xi’an710072China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Titanium alloys have been widely used in many industrial clusters such as automotive, aerospace and biomedical industries due to their excellent comprehensive properties. In order to obtain fine microstructures and favorable properties, a well-designed multi-step thermomechanical processing(TMP) is critically needed in manufacturing of titanium components. In making of titanium components,subtransus processing is a critical step to breakdown lamellar microstructure to fine-structure in hot working process and thus plays a key role in tailoring the final microstructure and properties. To realize this goal, huge efforts have been made to investigate the mechanisms of microstructure evolution and flow behavior during the subtransus processing. This paper reviews the recent experimental and modelling progresses, which aim to provide some guidelines for the process design and microstructure tailoring for titanium alloy research community. The characteristics of the initial lamellar microstructure are presented, followed by the discussion on microstructure evolution during subtransus processing. The globularization of lamellar α is analyzed in detail from three aspects, i.e., globularization mechanism, heterogeneity and kinetics. The typical features of flow behaviors and the explanations of significant flow softening are then summarized. The recent advances in modelling of microstructure evolution and flow behaviors in the subtransus processing are also articulated. The current tantalized issues and challenges in understanding of the microstructure evolution and flow behaviors of the titanium alloys with lamellar microstructure are presented and specified in future exploration of them.

关键词： Titanium alloys Lamellar microstructure Deformation behavior Microstructure evolution

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Mesoscale deformation mechanisms in relation with slip and grain boundary sliding in TA15 titanium alloy during tensile deformation

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Journal of Materials Science & Technology 2022年第3期98卷 72-86页

作者： yanxi li Pengfei Gao Jingyue Yu Shuo Jin Shuqun Chen Mei Zhan State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of High-Performance Precision Forming Technology and EquipmentSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Advanced Functional Materials Education Ministry of ChinaSchool of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124China

Revealing the mesoscale deformation mechanisms of titanium alloy with tri-modal microstructure is of great significance to improve its mechanical properties. In this work, the collective behavior and mechanisms of slip activities, slip transfer, and grain boundary sliding of tri-modal microstructure were investigated by the combination of quasi-in-situ tensile test, SEM, EBSD and quantitative slip trace analyses. It is found that the slip behavior presents different characteristics in the equiaxed α(α_(p)) and lamellar α(α_(l))grains. Under a low level of deformation, almost all the slip deformation is governed by single basal and prismatic slips for both of α_(p)and α_(l),despite small amount of -pyramidal slip exists in α_(l)grains. As deformation proceeds, -pyramidal and -pyramidal slip systems with high Schmid factors were activated in quantities. Specially, certain coarse prismatic slip bands were produced across both of single and colony α_(l)grains whose major axes tilting about 40 °–70 ° from the tensile axis. Slip transfer occurs at the boundaries of α_(p)/α_(p)and α_(l)/β under the condition that there exists perfect alignment between two slip systems and high Schmid factors of outgoing slip system. The slip transfer across α_(l)/β boundary can be divided into two types: straight slip transfer and deflect slip transfer with a deviation angle of 5 °–12 °, depending on the alignment of slip planes of two slip systems. The grain boundary sliding along boundaries of α_(l)/β and α_(p)/β was captured by covering micro-grid on tensile sample. It is found that the crystallographic orientation and the geometrical orientation related to loading axis play great roles in the occurrence of grain boundary sliding.

关键词： Titanium alloy Tri-modal microstructure Slip modes Slip transfer Grain boundary sliding

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Nutritional values,bioactive compounds and health benefits of purslane(Portulaca oleracea L.):a comprehensive review

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Food Science and Human Wellness 2024年第5期13卷 2480-2501页

作者： yanxi li Longgao Xiao Huan Yan Mingyi Wu Xiaojiang Hao Haiyang liu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Yunnan Characteristic Plant Extraction Laboratory Kunming 650106China

Portulaca oleracea L.,commonly known as purslane,is a worldwide weed species belonging to the family Portulacaceae and has been known as“Global Panacea”.As one of the most widely consumed green vegetables and medicinal plants around the world,it has recently been re-evaluated as a potential“new crop”due to the properties that differentiate it as one of the best vegetable sources of omega-3 fatty acid(α-linolenic acid),as well as a variety of nutrients and ***,emerging research has found that purslane exhibits health-promoting properties like anti-inflammatory,anti-hyperglycemic,antioxidant,neuroprotective,and *** findings suggest that this species possesses a potential using as a dietary supplement beyond potherb and traditional *** review systematically summarizes the up-to-date research carried out on purslane,including the nutritional compositions,bioactive compounds,and health benefits it exerts as well as limitations,challenges,and future directions of ***,we hope that this review would provide purslane with a comprehensive reference and future scope as functional and health-promoting food for disease prevention and treatment.

关键词： Purslane Nutritional compositions Bioactive compounds Polysaccharides Functional foods

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A review of lithium-ion battery safety concerns:The issues,strategies,and testing standards

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Journal of Energy Chemistry 2021年第8期30卷 83-99,I0003页

作者： Yuqing Chen Yuqiong Kang Yun Zhao li Wang Jilei liu yanxi li Zheng liang Xiangming He Xing li Naser Tavajohi Baohua li College of Materials Science and Engineering Hunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangsha 410082China Engineering Laboratory for Next Generation Power and Energy Storage Batteries Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China Institute of Nuclear&New Energy Technology Tsinghua University100084 BeijingChina Department of Materials Science and Engineering Stanford University94305 StanfordUSA Technical Center SAIC Motor201804 ShanghaiChina Department of Chemistry UmeåUniversity90187 UmeåSweden

Efficient and reliable energy storage systems are crucial for our modern ***-ion batteries(liBs)with excellent performance are widely used in portable electronics and electric vehicles(EVs),but frequent fires and explosions limit their further and more widespread *** review summarizes aspects of liB safety and discusses the related issues,strategies,and testing ***,it begins with a brief introduction to liB working principles and cell structures,and then provides an overview of the notorious thermal runaway,with an emphasis on the effects of mechanical,electrical,and thermal *** following sections examine strategies for improving cell safety,including approaches through cell chemistry,cooling,and balancing,afterwards describing current safety standards and corresponding *** review concludes with insights into potential future developments and the prospects for safer liBs.

关键词： lithium-ion batteries Standards Safety Thermal abuse Mechanical abuse Electrical abuse

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SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS

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Genes & Diseases 2021年第1期8卷 94-109页

作者： Jing Luo Hong Ye lijuan Hao Yixuan Sun Ruohan li yanxi li Zhu Yang Gynecology and Obstetrics of the Second Affiliated Hospital of Chongqing Medical University ChongqingPR China Gynecologic Endocrinology of Chongqing Health Center for Women and Children ChongqingPR China

Ovarian hyperandrogenism is one of the characteristics of polycystic ovary syndrome(PCOS)and androgen receptor(AR)in ovarian granulosa cells(GCs)functions as an important element to the accumulation of *** study verified the existence of alternative splicing variant of AR(AR-SVs)in the GCs of PCOS patients and found that the function of AR decreased significantly in the presence of *** compared to the normal individuals,the expression of Serine/arginine-rich splicing factor 2(SRSF2)was higher and the expression of SRSF3 was lower in the GCs of patients with *** importantly,we found that the expression of SRSF2 was inhibited and that the expression of AR was decreased after the successful upregulation of miRNA-183,and testostrone(T)concentrations in the culture medium were *** results also showed that the expression of SRSF3 decreased when miRNA-124 was successfully upregulated,while the expression of AR significantly increased;however,the function of AR was also inhibited when T concentration in the culture medium was *** study has proved that SRSFs are regulated by corresponding miRNAs,and the altered expression of SRSFs interferenced the alternative splicing process of AR and ultimately decreased the function of AR,leading to the accumulation of androgens in the ovary.

关键词： Androgen receptor Granulosa cells Hyperandrogenism miRNAs PCOS SRSFs

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Peer effect on climate risk information disclosure

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China Journal of Accounting Research 2024年第3期17卷 168-197页

作者： yanxi li Duo Wang Delin Meng Yunge Hu School of Economics and Management Dalian University of TechnologyDalianChina

In this study,we examine the peer effect on climate risk information disclosure by analyzing A-share listed companies in *** find that industry peers influence target firms’climate risk information disclosure through active(passive)imitation resulting from cost-benefit considerations(institutional pressures).Leader companies are more likely to be emulated by within-industry follower companies and target firms prefer to learn from similar withinindustry *** overconfidence and performance pressure negatively affect target firms’willingness to emulate their ***,the peer effect of climate risk information disclosure demonstrates a regional *** findings have implications for reasonable climate risk information disclosure at the micro level and effective regulation to move toward achieving carbon peak/neutrality at the macro level.

关键词： Climate Risk Information Disclosure Peer Effect Institutional Pressure Cost-Benefit

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Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia cos-tus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation

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Chinese Journal of Natural Medicines 2024年第11期22卷 1011-1019页

作者： XIAO Longgao ZHAO Yueqin DING Xiao liU Hui ZHU Guangyu li yanxi YAN Huan FANG Xin ZHAO Yuhan liU Haiyang State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Yunnan Characteristic Plant Extraction Laboratory Kunming 650106China

Three novel sesquiterpenoid heterodimers,designated as auckcostusolides A-C(1-3),were isolated from Aucklandia costus *** structures of compounds 1-3 were elucidated through comprehensive spectroscopic analysis,with their absolute configurations established using a combination of X-ray single-crystal diffraction and electronic circular dichroism(ECD)***,compounds 1 and 2,despite sharing identical planar structures derived from two identical sesquiterpenoids,exhibited oppos-ite configurations at C-11 and C-8'.This configurational difference can be attributed to distinct Diels-Alder cycloaddition processes between the sesquiterpenoid ***,the cytotoxic effects of compounds 1-3 were evaluated against colorectal can-cer HCT116 cells,fibrosarcoma HT1080 cells,and hepatocellular carcinoma HepG2 *** 1-3 induced cell death was characterized by endoplasmic reticulum(ER)swelling and cytoplasmic vacuolization,typical morphological changes associated with *** studies revealed that compounds 1 and 3 triggered paraptosis-like cell death through the accumulation of react-ive oxygen species(ROS),activation of ER stress,and stimulation of the MAPK signaling pathway.

关键词： Aucklandia costus Sesquiterpenoid heterodimers Auckcostusolides A-CParaptosis MAPK signaling pathway

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