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Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia shang Yi Fang Bin Guan Jian-Hua Guan Jun Peng jin-Yan Zhao Jiu-Mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

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Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： Jiahui Xu Minghao Wang Minyi jin Siyan shang Chuner Ni Yili Hu Xun Sun Jun Xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

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多甲基α-吡喃酮的简捷合成方法

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华东理工大学学报（自然科学版） 2005年第2期31卷 177-179页

作者：孙军袁鹄马德琈杨尚金薛仲华华东理工大学药物化工研究所上海200237 上海工程技术大学上海200336

以α-甲基丙酰乙酸乙酯为原料,经动力学去质子化后,与乙酸乙酯发生γ-酰基化反应,然后环合生成3,5,6-三甲基-4-羟基-2-吡喃酮,在回流丁酮中甲基化主要得到3,5,6-三甲基-4-甲氧基-2-吡喃酮。两步反应总收率15.2%,经IR,1H-NMR,MS分析确定... 详细信息

以α-甲基丙酰乙酸乙酯为原料,经动力学去质子化后,与乙酸乙酯发生γ-酰基化反应,然后环合生成3,5,6-三甲基-4-羟基-2-吡喃酮,在回流丁酮中甲基化主要得到3,5,6-三甲基-4-甲氧基-2-吡喃酮。两步反应总收率15.2%,经IR,1H-NMR,MS分析确定了目标化合物的分子结构。

关键词：吡喃酮酰基化甲基化

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Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder

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China Foundry 2024年第2期21卷 197-204页

作者： Chun-jie Xu Yuan-ying jin Dong Ma Zhen Zhao Jia-wei Qi shang Sui Xiang-quan Wu Can Guo Zhong-ming Zhang Yong-hui Liu Dan Shechtman School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048China Xi'an Shechtman Nobel Prize New Materials Institute Xi'an 710048China Tongchuan Huazhu Precision Technology Co. Ltd.Tongchuan 727100ShaanxiChina Faculty of Materials Science and Engineering Technion-Israel Insititue of TechnologyHaifa 3200003Israel

It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial *** this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 *** microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were *** results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and *** the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are *** the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the *** the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification ***,the microstructure in the lower part of the section solidifies relatively *** left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,*** tensile fracture belongs to the ductile-brittle hybrid *** comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.

关键词： horizontal continuous casting(HCC) nodular cast iron ductile iron bars microstructure mechanical properties

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数据非依赖采集张量质谱数据计算平台的开发

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质谱学报 2024年第3期45卷 412-421,I0005页

作者：周海洋刘朋欢金尚忠中国计量大学光学与电子科技学院浙江杭州310000

数据非依赖采集张量(data independent acquisition tensor,DIAT)是一种质谱数据格式,用于处理和分析数据非依赖采集方法获得的蛋白质组学数据。与传统方法相比,DIAT技术具有便捷的数据可视化处理和高效的深度学习模型训练等优势。但由... 详细信息

数据非依赖采集张量(data independent acquisition tensor,DIAT)是一种质谱数据格式,用于处理和分析数据非依赖采集方法获得的蛋白质组学数据。与传统方法相比,DIAT技术具有便捷的数据可视化处理和高效的深度学习模型训练等优势。但由于目前缺乏支持DIAT格式数据的软件平台,限制了其应用。为解决这一问题,本文基于PyQt框架设计了一款用于处理和分析DIAT数据的软件,涵盖了与DIAT技术相关的所有功能,使用户能够轻松地利用DIAT数据进行复杂分析,降低了使用门槛,为数据非依赖采集(DIA)质谱数据分析注入了活力。

关键词：质谱数据非依赖采集(DIA) 图形化用户交互界面(GUI) 深度学习视觉变换网络

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Updated prevalence of latent prostate cancer in Chinese population and comparison of biopsy results: An autopsy-based study

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The Innovation 2024年第1期5卷 80-87页

作者： Yuliang Chen Zhien Zhou Yi Zhou Zhipeng Mai Shijie jin Zhen Liang Zhiyuan shang Yuzhi Zuo Yu Xiao Wenze Wang Haibo Wang Weigang Yan Department of Urology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Gynaecology and Obstetrics Beijing HospitalNational Centre of GerontologyBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Peking University Clinical Research Institute Peking University First HospitalBeijing 100034China

Prostate cancer detected by autopsy is named latent prostate *** the repertoire of clinical prostate cancer,latent cancer may better reflect the disease *** clinical prostate specimens,which are obtained exclusively from biopsy-positive cases,prostate specimens obtained through autopsy provide information on biopsy-negative cases,helping calculate the true sensitivity of prostate *** 2014 to 2021,we collected autopsy specimens of the prostate from body donors in China and performed transperineal and transrectal biopsies on specimens before step-sectioning and pathological *** found that the crude prevalence of latent prostate cancer in middle-aged and elderly men was 35.1%(81/231),which was higher than previous estimates for Chinese *** overall per-patient sensitivities of transperineal and transrectal biopsies were not significantly different(33.3%vs.32.1%,p=0.82),but the two approaches differed in preferential sampling area along the proximal-distal axis of the *** biopsy had a higher sensitivity for detecting clinically significant lesions in the distal third(34.7%vs.16.3%,p=0.02)and distal half(30.6%vs.18.1%,p=0.04),while transrectal biopsy had a higher sensitivity for lesions in the proximal half(25.0%vs.13.9%,p=0.046).Both transperineal and transrectal methods of biopsy missed most small lesions(0.5 mL).In conclusion,the prevalence of latent prostate cancer in China has increased over the past 2 *** transperineal and transrectal methods of biopsy had comparable sensitivities but had different preferential sampling *** approaches miss one-third of large lesions.

关键词： biopsy prevalence latent

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Investigation of the quality of life,mental status in patients with gynecological cancer and its influencing factors

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World Journal of Psychiatry 2024年第7期14卷 1053-1061页

作者： Hai-Xia shang Wen-Ting Ning jin-Fen Sun Nan Guo Xin Guo Jan-Nan Zhang Hong-Xin Yu Su-Hui Wu Department of Gynaecology and Obstetrics The Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Having a gynecological tumor or undergoing treatment can be a traumatic experience for women,as it affects their self-image and sexual relationships and can lead to psychological *** adjustment following cancer occurrence remains a key issue among the *** To examine the current status of quality of life(QoL),anxiety,and depression in patients with gynecological cancer and to analyze the factors associated with *** Data for 160 patients with gynecological malignancies treated at Shanxi Bethune Hospital from June 2020 to June 2023 were collected and analyzed ***’QoL was assessed using the European Organization for Research on Treatment of Cancer Quality of Life Questionnaire Core 30 and the Functional Assessment of Cancer Therapy-General *** emotional status was evaluated using the Self-Rating Anxiety/Depression *** associated factors of anxiety and depression were *** The overall QoL score of the patients 6 months after surgery was 76.39±3.63 *** included low levels of social and emotional function and severe fatigue and *** scores for physiological,functional,emotional,social,and family well-being exhibited an upward trend following surgery compared with those before *** month after surgery,some patients experienced anxiety and depression,with an incidence of 18.75%and 18.13%,*** analysis revealed that good sleep was a protective factor against anxiety and depression in patients with gynecological tumors,whereas physical pain was a risk *** Patients with gynecological malignancies often experience anxiety and *** analyzing the factors that affect patients’QoL,effective nursing measures can be administered.

关键词： Gynecological Tumors Quality of life Anxiety Depression

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A von-Neumann-like photonic processor and its application in studying quantum signature of chaos

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Light(Science & Applications) 2024年第4期13卷 672-681页

作者： shang Yu Wei Liu Si-jing Tao Zhi-Peng Li Yi-Tao Wang Zhi-Peng Zhong Raj BPatel Yu Meng Yuan-Ze yang Zhao-An Wang Nai-Jie Guo Xiao-Dong Zeng Zhe Chen Liang Xu Ning Zhang Xiao Liu Mu yang Wen-Hao Zhang Zong-Quan Zhou jin-Shi Xu Jian-Shun Tang Yong-Jian Han Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China. CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China. Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China. Research Center for Quantum Sensing Zhejiang LabHangzhou 310000China. Quantum Optics and Laser Science Blackett LaboratoryImperial College LondonPrince Consort RdLondon SW72AZUK. Clarendon Laboratory Department of PhysicsOxford UniversityParks Road OX13PUOxfordUK

Photonic quantum computation plays an important role and offers unique *** decades after the milestone work of Knill-Laflamme-Milburn,various architectures of photonic processors have been proposed,and quantum advantage over classical computers has also been *** is now the opportune time to apply this technology to real-world ***,at current technology level,this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors,for which the resource cost is also a *** we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table,which is capable of multimode-universal programmability,resource-efficiency,phasestability and *** order to illustrate these merits,we execute two different programs with varying resource requirements on the same processor,to investigate quantum signature of chaos from two aspects:the signature behaviors exhibited in phase space(13 modes),and the Fermi golden rule which has not been experimentally studied in quantitative way before(26 modes).The maximal program contains an optical interferometer network with 1694 freely-adjustable *** current state-of-the-art,our architecture stands as the most promising candidate for real-world applications.

关键词： quantum signature chaos

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Investigation on vehicle occupant dummy applicability for under-foot impactloading conditions

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Chinese Journal of Traumatology 2024年第4期27卷 235-241页

作者： Teng-Fei Tian Fu-Hao Mo Hao-yang Su Can Huang Hui Zhao Jun Liu Bo shang Kui Li jin-Long Qiu State Key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan UniversityChangsha410082China Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Zhongzheng Judicial Expert Center Chongqing400020China NIO Limited Liability Company Shanghai200050China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China

Purpose:Under-foot impact loadings can cause serious lower limb injuries in many activities,such asautomobile collisions and underbody explosions to military *** present study aims to comparethe biomechanical responses of the mainstream vehicle occupant dummies with the human body lowerlimb model and analyze their robustness and applicability for assessing lower limb injury risk in underfoot impact loading ***:The Hybrid III model,the test device for human occupant restraint(THOR)model,and a hybridhuman body model with the human active lower limb model were adopted for under-foot impactanalysis regarding different impact velocities and initial lower limb ***:The results show that the 2 dummy models have larger peak tibial axial force and highersensitivity to the impact velocities and initial postures than the human lower limb *** particular,the Hybrid III dummy model presented extremely larger peak tibial axial forces than the human lowerlimb *** the case of minimal difference in tibial axial force,Hybrid III's tibial axial force(7.5 KN)isstill 312.5%that of human active lower limb's(2.4 KN).Even with closer peak tibial axial force values,thebiomechanical response curve shapes of the THOR model show significant differences from the humanlower limb ***:Based on the present results,the Hybrid III dummy cannot be used to evaluate the lowerlimb injury risk in under-foot loading *** contrast,potential improvement in ankle biofidelity and related soft tissues of the THOR dummy can be implemented in the future for betterapplicability.

关键词： Lower limb Under-foot impact Human body model Dummy Finite element model

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Efficient parameter inference for gravitational wave signals in the presence of transient noises using temporal and time-spectral fusion normalizing flow

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Chinese Physics C 2024年第4期48卷 240-251页

作者：孙天阳熊春雨金上捷王钰鑫张敬飞张鑫 Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

Glitches represent a category of non-Gaussian and transient noise that frequently intersects with gravitational wave(GW)signals,thereby exerting a notable impact on the processing of GW *** inference of GW parameters,crucial for GW astronomy research,is particularly susceptible to such *** this study,we pioneer the utilization of a temporal and time-spectral fusion normalizing flow for likelihood-free inference of GW parameters,seamlessly integrating the high temporal resolution of the time domain with the frequency separation characteristics of both time and frequency ***,our findings indicate that the accuracy of this inference method is comparable to that of traditional non-glitch sampling ***,our approach exhibits a greater efficiency,boasting processing times on the order of *** conclusion,the application of a normalizing flow emerges as pivotal in handling GW signals affected by transient noises,offering a promising avenue for enhancing the field of GW astronomy research.

关键词： gravitational wave glitch non-Gaussian and transient noise normalizing flow machine learning likelihood-free parameter inference

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