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Improvement of increased cQTd is associated with heart function in patients with ischemic heart failure

Journal of Geriatric Cardiology 2018年第1期15卷 41-49页

作者： Hui GUO Miao WANG Juan ZHAO Jing LIU Jie-mei yang Department of Cardiology the First Affiliated Hospital of Harbin Medical University Harbin China Department of Cardiology Ultrasound the First Affiliated Hospital of Harbin Medical University Harbin China

Background Chronic heart failure （CHF） is life-threatening without timely or effective intervention. In this study, we investigated the association between QT dispersion corrected for heart rate （cQTd） and heart function in patients with CHF. Methods From January 2013 to December 2015, we continuously enrolled 240 patients categorized as New York Heart Association functional class （NYHA） III-IV with a left ventricular ejection fraction （LVEF）〈 40%. Based on the etiology, the patients were divided into a dilated cardiomyopathy （DCM） group （n = 120） and an ischemic cardiomyopathy （ICM） group （n = 120）. Then, based on the cQTd width, the ICM group was divided into two subgroups： a QS group （cQTd ≤60 ms, n = 70） and a QL group （cQTd 〉 60 ms, n = 50）. All patients were examined by echocardiography and 12-lead electrocardiography （ECG） at 1, 3, 6, and 12 months after enrollment. Results After one year of optimized medical treatment, patients in both groups showed significant improvement in LVEF and NYHA classification from baseline. However, the cQTd in the ICM group, especially the QL, was significantly shorter than that in the DCM group at each time point. In addition, the cQTd was negatively correlated with LVEF and 6-min walking test and positively correlated with NYHA class in the ICM group. Conclusions The present findings clearly demonstrate that cQTd is a meaningful parameter for assessing heart function in the follow-up of ICM patients.

关键词： Cardiac dyssynchrony Chronic heart failure Corrected QT dispersion Heart function Ischemic cardiomyopathy

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Suppression of Replication of Rabies Virus by Short Hairpin RNAs Expressed by Plasmid

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畜牧兽医学报 2011年第B12期42卷 24-29页

作者： yang Rui-mei yang Song-tao XIA Xian-zhu College of Animal Science and Veterinary Medicine Qingdao Agricultural University Qingdao 265200 China Institute of Military Veterinary Academy of Military Medical Sciences Changchun 130062 China）

Targeting the N gene of rabies virus (RV), four shRNA expression plasmids were designed and constructed based on the vector pRNATU6.3-Hygro that expresses fusion protein with GFP as a reporter gene. Four cell strains (N1, N2, N3, N4) expressing the short hairpin RNAs (shRNA) were obtained after the plasmids were transfected into BHK-21 cells and screened under the pressure of Hygromycin B (300 μg/mL). These cell strains were infected with 100× the TCID 50 of rabies virus CVS-11 strain, and the viral replication was quantified at 24, 48, 72 and 96 hours by directed immunofluorescence assay (DFA), real-time PCR, and the 50% tissue culture infective dose (TCID 50 ). The results showed variable inhibition of viral replication, with BHK-N2 being the most effective strain (99% inhibition). There was close correspondence between results using the three methods of evaluation. The shRNA-mediated inhibition persisted to at least 96 hours after infection. Effective inhibition of replication of RV in BHK-21 cells was achieved by siRNA targeting the N gene, with N 2 , aimed at the region starting at position 701 of the gene, being the most potent.

关键词： shRNA 病毒复制狂犬病毒发夹结构质粒表达 BHK-21细胞短发夹RNA 实时PCR

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Fischer-Tropsch wax catalytic cracking for the production of low olefin and high octane number gasoline: Process optimization and heat effect calculation

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Petroleum Science 2023年第2期20卷 1255-1265页

作者： mei yang Gang Wang Jian-Nian Han Cheng-Di Gao Jin-Sen Gao State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and and EnvironmentChina University of PetroleumBeijing 102249China College of Science China University of PetroleumBeijing 102249China

To produce low olefin gasoline with high octane number by Fischer-Tropsch (F-T) wax fluid catalytic cracking (FCC) process, operating conditions optimization were carried out in the pilot-scale riser and turbulent fluidized bed (TFB) FCC unit. The experimental results in the riser indicated that under the condition of low reaction temperature and regenerated catalyst temperature, large catalyst-to-oil weight ratio (C/O) and long reaction time, the gasoline olefin content could be reduced to 20.28 wt%, but there is large octane number loss owing to a great loss in high octane number olefin. Therefore, a novel FCC process using the TFB reactor was proposed to strengthen the aromatization reaction. The reaction performance of TFB reactor were investigated. The result demonstrated that the TFB reactor has more significant effect in reducing olefins and improving aromatics. At the expense of certain gasoline yield, the gasoline olefin content reduced to 23.70 wt%, aromatics content could increase to 26.79 wt% and the RON was up to 91.0. The comparison of reactor structure and fluidization demonstrated that the TFB reactor has higher catalyst bed density. The reaction heat and coke combustion heat was calculated indicating the feasibility of its industrial application of the TFB process.

关键词： Fischer-Tropsch wax Catalytic cracking Riser TFB Gasoline olefin Reaction heat

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Diversity of ds RNA Viruses Infecting Rice Sheath Blight Fungus Rhizoctonia solani AG-1 IA

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Rice science 2018年第1期25卷 57-60页

作者： ZHENG Li LIU Chen ZHANG meiling yang mei ZHOU Erxun Guangdong Province Key Laboratory of Microbial Signals and Disease Control/College of Agriculture South China Agricultural University

Rice sheath blight,caused by Rhizoctonia solani(Kühn),is a notorious soil-borne disease prevalent in many rice-growing *** several sporadic studies of mycoviruses in *** AG-1 IA have been reported for single strain of *** AG-1 IA,there have been no reports describing the distribution and diversity of mycoviruses in natural *** this study,43 *** AG-1 IA strains collected from different locations in China were examined for the presence of ds RNA elements to confirm the presence of viral *** showed that 16 of the 43 fungal strains(37.2%)contained ds RNAs that can be characterized as ***,the species-specific reverse transcription PCR(RT-PCR)showed ds RNA bands with similar sizes do not always contain the same virus but exist as mixed mycoviral ***,our findings indicate mycoviruses infecting *** AG-1 IA in China are diverse,widespread and universal.

关键词： mycovirus Rhizoctonia solani reverse transcription polymerase chain reaction diversity dsRNA rice sheath blight

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Frequency synchronization for TD-LTE-A downlink receiver

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The Journal of China Universities of Posts and Telecommunications 2012年第1期19卷 31-37页

作者： JIA Guo-qing XIONG Yong yang Xiu-mei FANG Wei-dong Shanghai Research Center for Wireless Communications Shanghai 200335 China Shanghai Institute of Micro-System and Information Technology Chinese Academy of Sciences Shanghai 200050 China Key Laboratory of Wireless Sensor Network ＆ Communication Shanghai Institute of Micro-System and Information Technology Chinese Academy of Sciences Shanghai 200335 China

A high accuracy frequency synchronization method is proposed for the 3rd generation partnership project （3GPP） long term evolution advanced （LTE-A） downlink receiver in time division duplexing （TDD） mode. In general, cyclic prefix （CP） correlation based fractional frequency offset （FFO） estimation method and primary synchronization signal （PSS） differential correlation based integer frequency offset （IFO） estimation method are applied for LTE-A frequency synchronization. However, the polarity of CP based FFO estimation result may get reversed when system FFO is closer to the edge of frequency estimation range on account of noise interference; PSS based IFO estimation has performance degradation in low signal noise ratio （SNR）. We propose polarity detection aided CP based FFO estimation and frequency domain enhanced differential correlation based IFO estimation to obtain higher accuracy of frequency synchronization. Computer simulation shows that the proposed method greatly outperforms the conventional methods, especially in low SNR scenario.

关键词： Time-division long term evolution advanced (TD-LTE-A) frequency synchronization high accuracy polarity reversion resistance

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Ultrasonic cavitation-enabled microfluidic approach toward the continuous synthesis of cesium lead halide perovskite nanocrystals

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Chinese Journal of Chemical Engineering 2023年第7期59卷 32-41页

作者： Mingzhi Li Zhikai Liu Wang Yao Chao Xu yangping Yu mei yang Guangwen Chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Ligand assisted reprecipitation(LARP)is a widely used method for cesium lead halide perovskite nanocrystals(NCs)***,the ultrafast kinetics of LARP,as well as the inefficient transport properties and discontinuity of batch reactors,challenge the particle size control and experimental *** address these issues,an ultrasonic cavitation-enabled microfluidic approach was developed to achieve the continuous synthesis of cesium lead halide perovskite via *** was found that the mixing between the good solvent and antisolvent in the microchannel was greatly enhanced by intensive ultrasonic *** mixing time could be reduced to below 10 ms under the irradiation of 35 W *** modulating the mixing degree,LARP was proved to be a mixing-sensitive *** effects of ultrasonic power,ultrasonic treatment time,total flow rate,water additive,and reprecipitation temperature on the synthesis of CsPbBr_(3) NCs were systematically *** compared to CsPbBr_(3) NCs synthesized in the batch reactor,the sample synthesized via the ultrasonic cavitation-enabled microfluidic approach possessed stronger photoluminescence intensity and better ***,the ultrasonic cavitation-enabled microfluidic approach could also realize the continuous synthesis of cesium lead halide perovskite NCs with different halide compositions to cover a wide visible spectrum(426-661 nm).The ultrasonic cavitation-enabled microfluidic approach paved the way for the large-scale of high-quality cesium lead halide perovskite NCs.

关键词： Microreactor Ultrasound Mixing CsPbBr_(3)nanocrystals Synthesis

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Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation

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World Journal of Diabetes 2021年第11期12卷 1875-1893页

作者： Zhi-Lin Xiao Li-Ping Ma Da-Feng yang mei yang Zhen-Yu Li mei-Fang Chen Department of Geriatric Cardiology National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Cardiology Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of Cardiovascular Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND The accumulation of advanced glycation end products(AGEs)have been implicated in the development and progression of diabetic ***,the role of profilin-1 as a multifunctional actin-binding protein in AGEs-induced atherosclerosis(AS)is largely *** To explore the potential role of profilin-1 in the pathogenesis of AS induced by AGEs,particularly in relation to the Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3)signaling *** Eighty-nine individuals undergoing coronary angiography were enrolled in the *** cytokine levels were detected using ELISA *** aortic vascular smooth muscle cells(RASMCs)were incubated with different compounds for different *** proliferation was determined by performing the MTT assay and EdU *** AGEs-induced vascular remodeling model was established in rats and histological and immunohistochemical analyses were *** mRNA and protein levels were detected using real-time PCR and Western blot analysis,*** vivo,shRNA transfection was performed to verify the role of profilin-1 in AGEs-induced proatherogenic mediator release and aortic *** analyses were performed using SPSS 22.0 *** Compared with the control group,plasma levels of profilin-1 and receptor for AGEs(RAGE)were significantly increased in patients with coronary artery disease,especially in those complicated with diabetes mellitus(P<0.01).The levels of profilin-1 were positively correlated with the levels of RAGE(P<0.01);additionally,the levels of both molecules were positively associated with the degree of coronary artery stenosis(P<0.01).In vivo,tail vein injections of AGEs induced the release of proatherogenic mediators,such as asymmetric dimethylarginine,intercellular adhesion molecule-1,and the N-terminus of procollagen III peptide,concomitant with apparent aortic morphological changes and significantly upregulated expression of t

关键词： Advanced glycation end products Profilin-1 Diabetic macroangiopathy Atherosclerosis Vascular remodeling Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

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The morphology and dynamic viscoelasticity for PPS/low-melting temperature glass hybrids prepared by melt blending

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Chinese Chemical Letters 2012年第4期23卷 478-480页

作者： Li Na Zhang Xiao Hu Zhang Hong mei yang Qiang Zheng Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027China Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of EducationZhejiang UniversityHangzhou 310027China

Polyphenylene sulfides（PPS） and low-melting temperature glasses（LMTG） were used to prepare a PPS/LMTG organicinorganic hybrid material by melt *** etched surfaces of the hybrids were observed by scanning electron microscope （SEM） and the images showed different dispersed phase morphologies compared to traditional filled composites,which maybe induced by *** rheometric expanded system（ARES） was used to investigate the rheological behaviors of the hybrids and the results showed that the strain y dependence of dynamic storage modulus G＇ for the hybrids with high contents of LMTG did not appear Payne effect.

关键词： Polyphenylene sulfides Low-melting temperature glasses Melt blending Rheological behavior

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From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations

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Journal of Bioresources and Bioproducts 2024年第2期9卷 185-196页

作者： Zongpu Xu Fang He Jing Yu Zhangze yang Yu Zhu Rong Liao Ruyin Lyu mei yang Liangjun Zhu Mingying yang Institute of Applied Bioresources College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Neurosurgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials,but also increase the economic *** as a very promising candidate has drawn considerable attention owing to its abundant sources and remarkable ***,pure chitosan materials usually exhibit insufficient mechanical properties and excessive swelling ratio,which seriously affected their in vivo stability and integrity when applied as tissue engineering ***,simultaneously improving the mechanical strength and biological compatibility of pure chitosan(CS)scaffolds becomes very ***,inspired by the fiber-reinforced con-struction of natural extracellular matrix and the porous structure of cancellous bone,we built silk microfibers/chitosan composite scaffolds via ice-templating *** biomimetic strategy achieved 500%of mechanical improvement to pure chitosan,and meanwhile still maintaining high porosity(>87%).In addition,the increased roughness of chitosan pore walls by embedded silk microfibers significantly promoted cell adhesion and *** importantly,after subcutaneous implantation in mice for four weeks,the composite scaffold showed greater struc-tural integrity,as well as better collagenation,angiogenesis,and osteogenesis abilities,suggesting its great potential in biomedicine.

关键词： Chitosan Biomimetic strategy Fiber-reinforced composite Mechanical property Biocompatibility

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Joint Deep Matching Model of OCT Retinal Layer Segmentation

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Computers, Materials & Continua 2020年第6期63卷 1485-1498页

作者： mei yang Yuanjie Zheng Weikuan Jia Yunlong He Tongtong Che Jinyu Cong School of Information Science and Engineering at Shandong Normal University Jinan250358China Key Lab of Intelligent Computing and Information Security in Universities of Shandong Shandong Provincial Key Laboratory for Novel Distributed Computer Software TechnologyInstitute of Biomedical SciencesShandong Normal UniversityJinan250358China INSA Lyon University of LyonCNRSInsermVilleurbanne69621 CedexFrance

Optical Coherence Tomography(OCT)is very important in medicine and provide useful diagnostic *** retinal layer thicknesses plays a vital role in pathophysiologic factors of many ocular *** the existing retinal layer segmentation approaches,learning or deep learning-based methods belong to the ***,most of these techniques rely on manual-marked layers and the performances are limited due to the image *** order to overcome this limitation,we build a framework based on gray value curve matching,which uses depth learning to match the curve for semi-automatic segmentation of retinal layers from *** depth convolution network learns the column correspondence in the OCT image *** whole OCT image participates in the depth convolution neural network operation,compares the gray value of each column,and matches the gray value sequence of the transformation column and the next *** this algorithm,when a boundary point is manually specified,we can accurately segment the boundary between retinal *** experimental results obtained from a 54-subjects database of both normal healthy eyes and affected eyes demonstrate the superior performances of our approach.

关键词： OCT retinal segmentation deep learning 1D convolution

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