Improvement of increased cQTd is associated with heart function in patients with ischemic heart failure
Improvement of increased cQTd is associated with heart function in patients with ischemic heart failure作者机构:Department of Cardiology the First Affiliated Hospital of Harbin Medical University Harbin China Department of Cardiology Ultrasound the First Affiliated Hospital of Harbin Medical University Harbin China
出 版 物:《Journal of Geriatric Cardiology》 (老年心脏病学杂志(英文版))
年 卷 期:2018年第15卷第1期
页 面:41-49页
核心收录:
学科分类:0710[理学-生物学] 07[理学] 08[工学] 0822[工学-轻工技术与工程] 071003[理学-生理学]
主 题:Cardiac dyssynchrony Chronic heart failure Corrected QT dispersion Heart function Ischemic cardiomyopathy
摘 要:Background Chronic heart failure (CHF) is life-threatening without timely or effective intervention. In this study, we investigated the association between QT dispersion corrected for heart rate (cQTd) and heart function in patients with CHF. Methods From January 2013 to December 2015, we continuously enrolled 240 patients categorized as New York Heart Association functional class (NYHA) III-IV with a left ventricular ejection fraction (LVEF) 〈 40%. Based on the etiology, the patients were divided into a dilated cardiomyopathy (DCM) group (n = 120) and an ischemic cardiomyopathy (ICM) group (n = 120). Then, based on the cQTd width, the ICM group was divided into two subgroups: a QS group (cQTd ≤60 ms, n = 70) and a QL group (cQTd 〉 60 ms, n = 50). All patients were examined by echocardiography and 12-lead electrocardiography (ECG) at 1, 3, 6, and 12 months after enrollment. Results After one year of optimized medical treatment, patients in both groups showed significant improvement in LVEF and NYHA classification from baseline. However, the cQTd in the ICM group, especially the QL, was significantly shorter than that in the DCM group at each time point. In addition, the cQTd was negatively correlated with LVEF and 6-min walking test and positively correlated with NYHA class in the ICM group. Conclusions The present findings clearly demonstrate that cQTd is a meaningful parameter for assessing heart function in the follow-up of ICM patients.