From common biomass materials to high-performance tissue engineering scaffold: Biomimetic preparation, properties characterization, in vitro and in vivo evaluations
作者机构：Institute of Applied BioresourcesCollege of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang ProvinceZhejiang UniversityHangzhou 310058China Department of Neurosurgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China
出 版 物：《Journal of Bioresources and Bioproducts》 (生物质资源与工程（英文）)
年 卷 期：2024年第9卷第2期
页 面：185-196页
核心收录：
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：supported by National Natural Science Foundation of China(No.52103149) State of Sericulture Industry Technol-ogy System(No.CARS-18-ZJ0501) Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province(No.2020E10025) Zhejiang University start-up fund,and the program“Construction of Mineralized Silk Fibroin Microfiber Rein-forced Chitosan Composite Scaffold and its Application in Bone Repair”
主 题：Chitosan Biomimetic strategy Fiber-reinforced composite Mechanical property Biocompatibility
摘 要：Converting common biomass materials to high-performance biomedical products could not only reduce the environmental pressure associated with the large-scale use of synthetic materials,but also increase the economic *** as a very promising candidate has drawn considerable attention owing to its abundant sources and remarkable ***,pure chitosan materials usually exhibit insufficient mechanical properties and excessive swelling ratio,which seriously affected their in vivo stability and integrity when applied as tissue engineering ***,simultaneously improving the mechanical strength and biological compatibility of pure chitosan(CS)scaffolds becomes very ***,inspired by the fiber-reinforced con-struction of natural extracellular matrix and the porous structure of cancellous bone,we built silk microfibers/chitosan composite scaffolds via ice-templating *** biomimetic strategy achieved 500%of mechanical improvement to pure chitosan,and meanwhile still maintaining high porosity(87%).In addition,the increased roughness of chitosan pore walls by embedded silk microfibers significantly promoted cell adhesion and *** importantly,after subcutaneous implantation in mice for four weeks,the composite scaffold showed greater struc-tural integrity,as well as better collagenation,angiogenesis,and osteogenesis abilities,suggesting its great potential in biomedicine.
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