检索结果-南通市图书馆

Asenic removal from groundwater using granular Chitosan-titanium adsorbent

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2022年第2期34卷 202-209页

作者： Zuben Xu Yaqin Yu Li Yan Wei Yan Chuanyong Jing State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China School of Environmental Science and Engineering Shandong UniversityQingdao 266237China

Arsenic(As)contamination poses an urgent environmental risk,and its removal from groundwater remains a challenge due to the lack of efficient adsorbents.Herein,a novel granular Chitosan-titanium(CS-Ti)adsorbent was fabricated by the sol-gel method.Batch experiments show that As(V)adsorption on CS-Ti followed the pseudo-second-order kinetic model,and the adsorption isotherm conformed to the Freundlich model with the correlation coefficient of 0.99.In situ FTIR spectra revealed that the CS-Ti adsorbent was composed of amorphous TiO_(x) and Chitosan by forming C-O-Ti and N-Ti bonds,and the amorphous TiO_(x) was responsible for As(V)adsorption.Rapid small-scale column tests show that 165.6μg/L of As in groundwater were effectively removed in approximately 126-bed volumes,and the spent adsorbents were regenerated with 0.01 mol/L Na OH and maintained the adsorption efficiency after four cycles.This study provides a simple and practical route to fabricate adsorbents for water treatment.

关键词： Arsenic Chitosan Titanium Groundwater Adsorption

A Chitosan-based antibacterial hydrogel with injectable and self-healing capabilities

在线全文

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2024年第1期6卷 115-125页

作者： Rui Chen Yanan Hao Secundo Francesco Xiangzhao Mao Wen-Can Huang State Key Laboratory of Marine Food Processing and Safety Control College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China Qingdao Key Laboratory of Food Biotechnology Qingdao 266404China Key Laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Istituto di Scienze e Tecnologie Chimiche“Giulio Natta” Consiglio Nazionale delle Ricerche via Mario Bianco 920131 MilanItaly

The presence of bacteria directly affects wound healing.Chitosan-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial properties.Here,a double-cross-linking Chitosanbased hydrogel with antibacterial,self-healing,and injectable properties is reported.Thiolated Chitosan was successfully prepared,and the thiolated Chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular hydrogel.Subsequently,the amine groups in the thiolated Chitosan covalently cross-linked with genipin to further promote hydrogel formation.In vitro experimental results indicate that hydrogel can release Ag^(+)over an extended time,achieving an antibacterial rate of over 99% against Escherichia coli and Staphylococcus aureus.Due to the reversible and dynamic feature of Ag-S coordination,an antibacterial hydrogel exhibited injectable and self-healing capabilities.Additionally,the hydrogel showed excellent biocompatibility and biodegradability.

关键词： Hydrogel Chitosan Silver ion Cross-linking Antibacterial

A Chitosan-mediated inhalable nanovaccine against SARS-CoV-2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第5期15卷 4191-4200页

作者： Shao-Hua Zhuo Jun-Jun Wu Lang Zhao Wen-Hao Li Yu-Fen Zhao Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Drug Discovery Technology Ningbo UniversityNingbo 315221China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),with several antigenic variants,has grown into a global challenge,and the rapid establishment of an immune barrier is crucial to achieving long-term control of the virus.This has led to a great demand for easy preparation and scalable vaccines,especially in low-income countries.Here,we present an inhalable nanovaccine comprising Chitosan and SARS-CoV-2 spike protein.The Chitosan-mediated nanovaccine enabled a strong spike-specific antibody immune response and augmented local mucosal immunity in bronchoalveolar lavage and lungs,which might be capable of protecting the host from infection without systemic toxicity.In addition,the enhanced adaptive immunity stimulated by Chitosan showed potential protection against SARS-CoV-2.Furthermore,inhalation of the nanovaccine induced a comparable antibody response compared to intramuscular injection.This inhalable nanovaccine against SARS-CoV-2 offers a convenient and compliant strategy to reduce the use of needles and the need for medical staff.

关键词： severe acute respiratory syndrome coronavirus 2(SASR-CoV-2) inhalation nanovaccine Chitosan

Puerarin@Chitosan composite for infected bone repair through mimicking the bio-functions of antimicrobial peptides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第3期21卷 520-530页

作者： Liping Ouyang Baohui Chen Xingdan Liu Donghui Wang Yang Li Yun Liao Kelvin W.K.Yeung Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Hongqiao International Institute of edicine Shanghai Jiao Tong University School of MedicineShanghai200336China Cixi Center of Biomaterials Surface Engineering Ningbo315300China Department of Computational Biology for Individualised Medicine Centre for Individualised Infection Medicine(CiiM)&TWINCOREJoint Ventures Between the Helmholtz-Centre for Infection Research(HZI)and the Hannover Medical School(MHH)HannoverGermany Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Guangdong Engineering Technology Research Center for Orthopaedic Trauma RepairDepartment of Orthopaedics and TraumatologyThe University of Hong Kong Shenzhen HospitalShenzhenChina

It is important to eliminate lipopolysaccharide(LPS)along with killing bacteria in periprosthetic joint infection(PJI)therapy for promoting bone repair due to its effect to regulate macrophages response.Although natural antimicrobial peptides(AMPs)offer a good solution,the unknown toxicity,high cost and exogenetic immune response hamper their applications in clinic.In this work,we fabricated a nanowire-like composite material,named P@C,by combining Chitosan and puerarin via solid-phase reaction,which can finely mimic the bio-functions of AMPs.Chitosan,serving as the bacteria membrane puncture agent,and puerarin,serving as the LPS target agent,synergistically destroy the bacterial membrane structure and inhibit its recovery,thus endowing P@C with good antibacterial property.In addition,P@C possesses good osteoimmunomodulation due to its ability of LPS elimination and macrophage differentiation modulation.The in vivo results show that P@C can inhibit the LPS induced bone destruction in the Escherichia coli infected rat.P@C exhibits superior bone regeneration in Escherichia coli infected rat due to the comprehensive functions of its superior antibacterial property,and its ability of LPS elimination and immunomodulation.P@C can well mimic the functions of AMPs,which provides a novel and effective method for treating the PJI in clinic.

关键词： Osteoimmunomodulation Antibacterial Chitosan Puerarin Lipopolysaccharide

Electrodeposition of Chitosan/graphene oxide conduit to enhance peripheral nerve regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第1期18卷 207-212页

作者： Ya-Nan Zhao Ping Wu Zi-Yuan Zhao Fei-Xiang Chen Ao Xiao Zhi-Yi Yue Xin-Wei Han Yong Zheng Yun Chen Department of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Clinical Medical College Hubei University of Science and TechnologyXianningHubei ProvinceChina

Currently available commercial nerve guidance conduits have been applied in the repair of peripheral nerve defects.However,a conduit exhibiting good biocompatibility remains to be developed.In this work,a series of Chitosan/graphene oxide(GO)films with concentrations of GO varying from 0-1 wt%(collectively referred to as CHGF-n)were prepared by an electrodeposition technique.The effects of CHGF-n on proliferation and adhesion abilities of Schwann cells were evaluated.The results showed that Schwann cells exhibited elongated spindle shapes and upregulated expression of nerve regeneration-related factors such as Krox20(a key myelination factor),Zeb2(essential for Schwann cell differentiation,myelination,and nerve repair),and transforming growth factorβ(a cytokine with regenerative functions).In addition,a nerve guidance conduit with a GO content of 0.25%(CHGFC-0.25)was implanted to repair a 10-mm sciatic nerve defect in rats.The results indicated improvements in sciatic functional index,electrophysiology,and sciatic nerve and gastrocnemius muscle histology compared with the CHGFC-0 group,and similar outcomes to the autograft group.In conclusion,we provide a candidate method for the repair of peripheral nerve defects using free-standing Chitosan/GO nerve conduits produced by electrodeposition.

关键词： Chitosan electrodeposition free-standing graphene oxide nerve conduit nerve factors Schwann cells tissue engineerin

Biomimetic Chitosan scaffolds with long-term controlled release of nerve growth factor repairs 20-mm-long sciatic nerve defects in rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第5期17卷 1146-1155页

作者： Fa-Dong Liu Hong-Mei Duan Fei Hao Wen Zhao Yu-Dan Gao Peng Hao Zhao-Yang Yang Xiao-Guang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Neurobiology Capital Medical UniversityBeijingChina Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijingChina

Although autogenous nerve transplantation is the gold standard for treating peripheral nerve defects of considerable length,it still has some shortcomings,such as insufficient donors and secondary injury.Composite Chitosan scaffolds loaded with controlled release of nerve growth factor can promote neuronal survival and axonal regeneration after short-segment sciatic nerve defects.However,the effects on extended nerve defects remain poorly understood.In this study,we used Chitosan scaffolds loaded with nerve growth factor for 8 weeks to repair long-segment(20 mm)sciatic nerve defects in adult rats.The results showed that treatment markedly promoted the recovery of motor and sensory functions.The regenerated sciatic nerve not only reconnected with neurons but neural circuits with the central nervous system were also reconstructed.In addition,the regenerated sciatic nerve reconnected the motor endplate with the target muscle.Therefore,this novel biomimetic scaffold can promote the regeneration of extended sciatic nerve defects and reconstruct functional circuits.This provides a promising method for the clinical treatment of extended peripheral nerve injury.This study was approved by the Animal Ethics Committee of Capital Medical University,China(approval No.AEEI-2017-033)on March 21,2017.

关键词： axon Chitosan functional recovery myelin sheath nerve growth factor peripheral nerve injury pseudorabies virus regeneration scaffold sciatic nerve

Chitosan-based carbon dots with multi-color-emissive tunable fluorescence and visible light catalytic enhancement properties

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第2期16卷 1835-1845页

作者： Qiong Wu Shouyun Zhang Shuang Li Yan Yan Shitao Yu Ruiyang Zhao Lang Huang State Key Laboratory Base of Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China

Carbon quantum dots(CQDs)are receiving increasing attention for their excellent photostability,low toxicity,and tunable fluorescence performance,but it is still challenging to prepare full-spectrum CQDs using only one single set of precursor and solvent.In this study,P and N co-doped carbon dots(N,PR-CQDs)with multi-color-emissive tunable fluorescence from blue to green and orange were synthesized from bio-based Chitosan,employing phosphoric acid as solvent and dopant.The introduction of phosphoric acid successfully shortens the manufacturing reaction time,and the heteratomic functional groups of P–O/P=O on surface of carbon dots enrich the surface defect states,promoting n–π*transition,and therefore changing their electron structure/energy level to reduce the band gap,thus facilitating emission at long wavelength.Specifically,increasing phosphoric acid concentration leads to characteristic excitation peaks red shift from 320 to 420 nm with the characteristic emission peaks red shift from 406 to 503 nm.A new emission peak at 610 nm appears,enabling N,PR-CQDs exhibit double emission peaks with fluorescence color from green to yellow to orange.After compositing with carbon nitride(g-C3N4),N,PR-CQDs work as photosensitizer and effectively narrow the energy gap(Eg)of g-C3N4 from 2.75 to 2.40 eV,endowing the photocatalyst higher visible light capture ability and broader light response region.The photocatalytic degradation rate of rhodamine B(RhB)under visible light irradiation reaches up to 98.39%within 60 min using N,P20%-CQDs/g-C3N4 as catalyst,which is 1.4 times that of pure g-C3N4,and it is demonstrated that·O2−is the major active substance contributing for RhB degradation by de-ethyl and aromatic ring breakage.

关键词： carbon dots multicolor luminescence Chitosan visible light catalysis photosensitizer

Low-temperature 3D-printed collagen/Chitosan scaffolds loaded with exosomes derived from neural stem cells pretreated with insulin growth factor-1 enhance neural regeneration after traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第9期18卷 1990-1998页

作者： Xiao-Yin Liu Yin-He Feng Qing-Bo Feng Jian-Yong Zhang Lin Zhong Peng Liu Shan Wang Yan-Ruo Huang Xu-Yi Chen Liang-Xue Zhou Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Department of Respiratory and Critical Care Medicine People’s Hospital of Deyang CityAffiliated Hospital of Chengdu College of MedicineDeyangSichuan ProvinceChina Department of Liver Surgery&Liver Transplantation State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduProvinceChina Department of General Surgery the Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina The First Affiliated Hospital of Chengdu Medical College ChengduSichuan ProvinceChina Department of Anesthesiology Huashan HospitalFudan UniversityShanghaiChina Institute of Medical Security for Maritime Rights Protection of Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina

There are various clinical treatments for traumatic brain injury,including surgery,drug therapy,and rehabilitation therapy;howeve r,the therapeutic effects are limited.Scaffolds combined with exosomes represent a promising but challenging method for improving the repair of traumatic brain injury.In this study,we determined the ability of a novel 3D-printed collagen/Chitosan scaffold loaded with exosomes derived from neural stem cells pretreated with insulin-like growth factor-1(3D-CC-INEXOS) to improve traumatic brain injury repair and functional recove ry after traumatic brain injury in rats.Composite scaffolds comprising collagen,Chitosan,and exosomes derived from neural stem cells pretreated with insulin-like growth fa ctor-1(INEXOS) continuously released exosomes for 2weeks.Transplantation of 3D-CC-INExos scaffolds significantly improved motor and cognitive functions in a rat traumatic brain injury model,as assessed by the Morris water maze test and modified neurological seve rity scores.In addition,immunofluorescence staining and transmission electron microscopy showed that3D-CC-INExos implantation significantly improved the recove ry of damaged nerve tissue in the injured area.In conclusion,this study suggests that transplanted3D-CC-INExos scaffolds might provide a potential strategy for the treatment of traumatic brain injury and lay a solid foundation for clinical translation.

关键词： 3D printing angiogenesis Chitosan collagen exosomes functional recovery insulin-like growth factor-1 neural regeneration neural stem cells traumatic brain injury

Polyelectrolyte Complexes between Hyperbranched and Linear Polysaccharides: Fucoidan/Chitosan

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第4期42卷 468-479页

作者： Ekaterina R.Gasilova Daria N.Poshina Aleksandra O.Sitnikova Natalia N.Saprykina Yury A.Skorik Institute of Macromolecular Compounds of the Russian Academy of Sciences Bolshoi VO 31St.Petersburg199004Russian Federation

Polyelectrolyte complexes(PECs)of hyperbranched(HB)and linear polysaccharides are promising as more effective encapsulation agents compared to PECs formed by linear polysaccharides.We investigated the PECs between the HB anionic polysaccharide fucoidan(FUC)and the cationic linear polysaccharide Chitosan(CS).The FUC had a molecular weight(MW)of 30×106.The PECs were prepared in three solvents(water,0.01 and 0.1 mol/L acetic acid)with CS of MW of 15,110 and 170 kDa,and deacetylation degrees(DDA)of 70%and 97%.The structures of the PECs and the initial FUC were investigated by multi-angle static and dynamic light scattering.As the FUC contained 18 wt%of—OSO3 groups and 5 wt%of uronic acid units,it was a“strong-weak”copolyanion,so the HB macromolecules of the FUC formed nanogel particles in 0.1 mol/L AcOH and open branched structures in water,as confirmed by the Kratky plots.After mixing the solutions of original components,the PEC structures underwent an equilibration period,the duration of which increased with the MW of CS.As the charge stoichiometry was approached,the PECs shrank;the fractal dimension approached unity,indicating the side-by-side packing of adjacent FUC branches with the help of CS.Secondary aggregation in the vicinity of the charge compensation was hardly observed,as it occurred in a very narrow region.The PEC content at theζ-potential inversion depended on solvents’pH and the DDA of CS.In the extreme case of core-shell PECs in 0.1 mol/L AcOH,obtained by mixing FUC nanogels with the solutions of high MW CS of 97%DDA,the protruding tails of CS formed a positively charged shell in the whole range of FUC content(10 wt%

关键词： Polyelectrolyte complexes Chitosan Hyperbranched fucoidan Light scattering