检索结果-南通市图书馆

De Novo Dissecting the Three‑Dimensional Facial Morphology of 2379 Han Chinese Individuals

在线全文

学校读者我要写书评

暂无评论

Phenomics 2024年第1期4卷 1-12页

作者： Hui Qiao jingze Tan Shaoqing Wen Menghan Zhang Shuhua Xu Li Jin State Key Laboratory of Genetic Engineering Center for Evolutionary BiologyCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of Contemporary Anthropology Human Phenome InstituteZhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Institute of Archaeological Science Fudan UniversityShanghai 200433China Institute of Modern Languages and Linguistics Fudan UniversityShanghai 200433China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Phenotypic diversity,especially that of facial morphology,has not been fully investigated in the Han Chinese,which is the largest ethnic group in the *** this study,we systematically analyzed a total of 14,838 facial traits representing 15 categories with both a large-scale three-dimensional(3D)manual landmarking database and computer-aided facial segmented phenotyping in 2379 Han Chinese *** results illustrate that homogeneous and heterogeneous facial morphological traits exist among Han Chinese populations across the three geographical regions:Zhengzhou,Taizhou,and *** identifed 1560 shared features from extracted phenotypes,which characterized well the basic facial morphology of the Han *** particular,heterogeneous phenotypes showing population structures corresponded to geographical *** greatest facial variation among these geographical populations was the angle of glabella,left subalare,and right cheilion(p=3.4×10^(−161)).Interestingly,we found that Han Chinese populations could be classifed into northern Han,central Han,and southern Han at the phenotypic level,and the facial morphological variation pattern of central Han Chinese was between the typical diferentiation of northern and southern Han *** result was highly consistent with the results revealed by the genetic *** fndings provide new insights into the analysis of multidimensional phenotypes as well as a valuable resource for further facial phenotype-genotype association studies in Han Chinese and East Asian populations.

关键词： Phenotypes Three-dimensional facial imaging Facial morphology Han Chinese

Protective role of fruits of Rosa odorata var. gigantea against WIRSinduced gastric mucosal injury in rats by modulating pathway related to inflammation, oxidative stress and apoptosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2024年第2期16卷 263-273页

作者： Xinnan Liu Zhen Yuan Lifei Luo Teng Wang Feng Zhao jingze Zhang Dailin Liu National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China

Objective: Rosa odorata var. gigantea is a popular medicinal plant. Some studies have demonstrated that ethanolic extract of the fruits of R. odorata var. gigantea(FOE) has gastroprotective properties. The aim of this study was to investigate the gastroprotective activity of FOE on water immersion restrained stress(WIRS)-induced gastric mucosal injury in a rat model and elucidate the possible molecular mechanisms ***: A rat stress ulcer model was established in this study using WIRS. After rats were treated with FOE orally for 7 d, the effect of FOE treatment was analyzed by hematoxylin and eosin(H&E) staining, and the changes of inflammatory factors, oxidative stress factors, and gastric-specific regulatory factors and pepsin in the blood and gastric tissues of rats were examined by ELISA assay. Molecular mechanism of FOE was investigated by immunohistochemical assay and Western ***: Compared with the WIRS group, FOE could diminish both the macroscopic and microscopic pathological morphology of gastric mucosa. FOE significantly preserved the antioxidants glutathione peroxidase(GSH-PX), superoxide dismutase(SOD) and catalase(CAT) contents;anti-inflammatory cytokines interleukin-10(IL-10) and prostaglandin E2(PGE2) levels as well as regulatory factors tumor necrosis factor-a(TGF-a) and somatostatin(SS) contents, while decreasing malondialdehyde(MDA), nitric oxide synthase(i NOS), tumor necrosis factor(TNF-a), interleukin-1β(IL-1β), interleukin-6(IL-6), gastrin(GAS)and endothelin(ET) levels. Moreover, FOE distinctly upregulated the expression of Nrf2, HO-1, Bcl2 and proliferating cell nuclear antigen(PCNA). In addition, FOE activated the expression of p-EGFR and downregulated the expression of NF-ΚB, Bax, Cleaved-caspase-3, Cyto-C and Cleaved-PARP1, thus promoting gastric mucosal cell ***: The current work demonstrated that FOE exerted a gastroprotective activity against gastric mucosal injury induced by WIRS. The underlying mecha

关键词： anti-apoptosis anti-inflammation anti-oxidation gastric mucosal injury Rosa odorata Sweet var.gigantea(Coll.et Hemsl.)Rehd.et Wils water immersion restrained stress

Sulphur-doped ordered mesoporous carbon with enhanced electrocatalytic activity for the oxygen reduction reaction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2016年第4期25卷 566-570页

作者： Liping Wang Weishang Jia Xiaofeng Liu jingze Li Maria Magdalena Titirici State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China School of Materials Science and Engineering Zhejiang University School of Materials Science and Engineering Queen Mary University of London Materials Research Institute Queen Mary University of London

Metal-free, heteroatom functionalized carbon-based catalysts have made remarkable progress in recent years in a wide range of applications related to energy storage and energy generation. In this study, high surface area mesoporous ordered sulphur doped carbon materials are obtained via one-pot hydrothermal synthesis of carbon/SBA-15 composite after removal of in-situ synthesized hard template SiO2. 2-thiophenecarboxy acid as sulphur source gives rise to sulphur doping level of 5.5 wt%. Comparing with pristine carbon, the sulphur doped mesoporous ordered carbon demonstrates improved electro-catalytic activity in the oxygen reduction reaction in alkaline solution. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.

关键词： Mesoporous ordered carbon Oxygen reduction reaction Electrocatalyst Heteroatom doping In-situ synthesis

曹雪芹的文体学思想——兼及脂评本《红楼梦》的文体文献学价值

在线全文

学校读者我要写书评

暂无评论

文艺理论研究 2014年第4期34卷 136-145页

作者：任竞泽陕西师范大学文学院

曹雪芹的文体学思想全面而系统,主要有四个方面:一是辨体与尊体。包括"必先度其体格宜与不宜"的辨"文各有体",以及宝玉评鉴《桃花行》的辨"人各有体"。二是得体与失体。这组对立概念范畴的文体内蕴丰富,此外还继承了曹丕的文体理论并亲... 详细信息

曹雪芹的文体学思想全面而系统,主要有四个方面:一是辨体与尊体。包括"必先度其体格宜与不宜"的辨"文各有体",以及宝玉评鉴《桃花行》的辨"人各有体"。二是得体与失体。这组对立概念范畴的文体内蕴丰富,此外还继承了曹丕的文体理论并亲自实践之。三是破体与变体。也就是打破传统文体规范,这表现在《芙蓉女儿诔》等文体革新中。四是传统与俗套。曹雪芹提倡打破传统小说文体的写法规范,这种文体观在小说原文和脂评批语中,反复借不落俗套等相类之语道出。脂砚斋批语中的大量文体言论是对曹雪芹文体学思想的补充、印证和完善,具有很高的文体文献学价值。

关键词：辨体破体得体曹雪芹脂砚斋文体学思想

hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2018年第10期9卷 896-901页

作者： Xinyu Zhu Min Li Xiaojun Xu Rui Zhang Xiaofei Zhang Zhuo Ma jingze Lu Tao Xu Junjie Hou Eli Song Key Laboratory of Molecular Biophysics of the Ministry of Educa-tion College of Life Science and Technology Huazhong Universityof Science and Technology Wuhan 430074 China National Laboratory of Biomacromolecules CAS Center forExcellence in Biomacromolecules Institute of Biophysics ChineseAcademy of Sciences Beijing 100101 China College of Life Sciences University of Chinese Academy ofSciences Beijing 100049 China

Dear Editor, Endocytosis is a crucial process employed by cells to internal- ize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokinesis, morphogenesis, cell adhesion and migration. Endocytosis is classified as clathrin-dependent endocytosis （CDE） or clathrin-independent endocytosis （CIE） according to its dependence on clathrin. Several different CIE pathways have been proposed, including caveolin-dependent endocytosis, flotillin-dependent endocytosis, the clathrin-inde- pendent carrier pathway, ARF6-dependent endocytosis, phagocytosis, macropinocytosis, the IL2RI3 pathway （Doherty and McMahon, 2009）, the newly identified fast endophilin-me- diated endocytosis pathway （Boucrot et al., 2015） and the EGFR-NCE pathway （Caldieri et al., 2017）.

关键词：

Water Assisted Self-Photoredox of 2-（1-Hydroxyethyl） 9,10-Anthraquinone: An Unusual Photochemistry Reaction in Aqueous Solution

在线全文

学校读者我要写书评

暂无评论

Water Assisted Self-Photoredox of 2-（1-Hydroxyethyl） 9,10-...

A Recovery Strategy in Manufacturing Supply Chains for Long-term Supply Disruption

中国化学会第十二届全国量子化学会议

作者： jingze Dai Xuebo Chen College of Chemistry Beijing Normal University

A new kind of photochemistry associated with meta-substituted anthraquinone（AQ）was reported,where a novel photoredox reaction reduces the ketone moiety to its alcohol,and the meta-substituted alcohol group is oxidized to its aldehyde（or ketone）.However,the precise mechanism for self-photoredox is still *** this work we use multi-configurational perturbation theory at the CASPT2//CASSCF//AMBER QM/MM level to investigate the photoredox reaction of 2-（1-Hydroxyethyl）9,10-Anthraquinone,which is proposed to proceed via three sequential reactions:an excited-state intermolecular proton transfer（ESIPT）,the photoinduced deprotonation,and the *** by photoexcitation,the charge transfer occurs from the aromatic ring of the benzyl alcohol to the carbonyl group,leading to an abundant gathering of negative charge around the center of the carbonyl group that can function as a potential acceptor for a proton transfer and then undergoes ESIPT aided by water ***,the system relaxes to the 3ππ*state from charge transfer 1ππ*state via an intersystem crossing（ISC）followed by deprotonation reaction from the methylene C-H *** self-redox reaction is achieved by protonation of another carbonyl group from the proton donor of aqueous solution in the ground state.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A Recovery Strategy in Manufacturing Supply Chains for Long-...

第40届中国控制会议

作者： jingze Chen Hongfeng Wang College of Information Science and Engineering Northeastern University

This paper presents a recovery strategy in manufacturing supply chains that copes with long-term supply disruptions such as those caused by the recent global outbreak of COVID-19 through a combination of product composition changes and safety inventory. A mixed integer programming model is developed for alternative supplier purchase order allocations and manufacturer production order allocations to minimize the profit loss caused by product composition changes after supply disruptions. A solution method that combines the ILOG CPLEX and MATLAB to be used to solve the model. The computational results show that the proposed recovery strategy can effectively reduce the loss of manufacturer after prolonged supply disruptions. The proposed model can help managers consider the optimal recovery strategy when the manufacturing supply chain experiences a long-term disruption.

关键词： Supply chain supply disruption recovery strategy product composition change

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

文体正变与辨体破体:元好问的文体观念论析

民族文学研究 2023年第5期41卷 116-131页

作者：任竞泽陕西师范大学文学院

以《论诗三十首》为总纲,元好问的文体观念丰富而自成体系,包括不以绳墨自拘的文体正变观、文章以体制为先的辨体论及其以词为诗与以文为诗的破体论等。元好问的文体观念受到宋代苏轼、黄庭坚、朱熹等人的影响,并与金代王若虚、刘祁及... 详细信息

以《论诗三十首》为总纲,元好问的文体观念丰富而自成体系,包括不以绳墨自拘的文体正变观、文章以体制为先的辨体论及其以词为诗与以文为诗的破体论等。元好问的文体观念受到宋代苏轼、黄庭坚、朱熹等人的影响,并与金代王若虚、刘祁及元代郝经、潘昂霄等人的文体观念有相通之处。这反映出宋金元文体观念的互相渗透,体现了多民族文化的交融与影响。

关键词：元好问正体变体以词为诗以文为诗遗山体

高精度传感器在LG-I型蒸渗计中的选择标定和检验应用方法

在线全文

学校读者我要写书评

暂无评论

仪器仪表学报 2005年第11期26卷 1163-1165页

作者：闫敬泽杨启国中国气象局兰州干旱气象研究所兰州730020

介绍高精度传感器在LG—I型蒸渗计应用中的线性度,稳定性,漂移率参数的调试标定方法,并对实际应用中稳定性,漂移率参数测量的可靠性进行检验和讨论。

关键词：传感器线性度稳定性漂移率