De Novo Dissecting the Three‑Dimensional Facial Morphology of 2379 Han Chinese Individuals
作者机构：State Key Laboratory of Genetic EngineeringCenter for Evolutionary BiologyCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of Contemporary AnthropologyHuman Phenome InstituteZhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Institute of Archaeological ScienceFudan UniversityShanghai 200433China Institute of Modern Languages and LinguisticsFudan UniversityShanghai 200433China Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China
出 版 物：《Phenomics》 (表型组学（英文）)
年 卷 期：2024年第4卷第1期
页 面：1-12页
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：the Basic Science Center Program(32288101) the National Natural Science Foundation of China(NSFC)grants(32271186,31771325,32030020,31961130380,T2122007,and 32070577) the National Science and Technology Basic Research Project(2015FY111700 to LJ)
主 题：Phenotypes Three-dimensional facial imaging Facial morphology Han Chinese
摘 要：Phenotypic diversity,especially that of facial morphology,has not been fully investigated in the Han Chinese,which is the largest ethnic group in the *** this study,we systematically analyzed a total of 14,838 facial traits representing 15 categories with both a large-scale three-dimensional(3D)manual landmarking database and computer-aided facial segmented phenotyping in 2379 Han Chinese *** results illustrate that homogeneous and heterogeneous facial morphological traits exist among Han Chinese populations across the three geographical regions:Zhengzhou,Taizhou,and *** identifed 1560 shared features from extracted phenotypes,which characterized well the basic facial morphology of the Han *** particular,heterogeneous phenotypes showing population structures corresponded to geographical *** greatest facial variation among these geographical populations was the angle of glabella,left subalare,and right cheilion(p=3.4×10^(−161)).Interestingly,we found that Han Chinese populations could be classifed into northern Han,central Han,and southern Han at the phenotypic level,and the facial morphological variation pattern of central Han Chinese was between the typical diferentiation of northern and southern Han *** result was highly consistent with the results revealed by the genetic *** fndings provide new insights into the analysis of multidimensional phenotypes as well as a valuable resource for further facial phenotype-genotype association studies in Han Chinese and East Asian populations.
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