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Splenic vasculopathy in portal hypertension patients

World Journal of Gastroenterology 2006年第17期12卷 2737-2741页

作者： Tao Li Ji-Yuan Ni yan-Wu qi Hai-yang Li Tong Zhang Zhen yang Department of Hepatic Surgery Tongji Hosptal Tongji medical College Huazhong University of Science and Technology Wuhan 430030 Hubei province China

AIM： To investigate the interaction between portal hypertension, splanchnic hyperdynamic circulation and splanchnic vasculopathy by observing splenic arterial and venous pathological changes and the role of extracellular matrix in the pathogenesis of portal hypertensive vasculopathy by measuring the expression of type Ⅰ and type Ⅲ procollagen mRNA in splenic venous walls of portal hypertensive patients. METHODS： Morphological changes of splenic arteries and veins taken from portal hypertensive patients （n = 20） and normal controls （n = 10） were observed under optical and electron microscope. Total RNA was extracted and the expression of type Ⅰ and type Ⅲ procollagen mRNA in splenic venous walls of portal hypertensive patients （n= 20） was semi-quantitatively detected using reverse transcription-polymerase chain reaction （RT-PCR）. RESULTS： Under optical microscope, splenic arterial intima was destroyed and internal elastic membrane and medial elastic fibers of the splenic arterial walls were degenerated and broken. Splenic venous intima became remarkably thick. Endothelial cells were not intact with formation of mural thrombus. The tunica media became thickened significantly due to hypertrophy of smooth muscles. Fibers and connective tissues were increased obviously. Under electron microscope, smooth muscle cells of the splenic arteries were degenerated and necrotized. Phenotypes of smooth muscle cells changed from constrictive into synthetic type. Red blood cells and platelets accumulated around the damaged endothelial cells. Synthetic smooth muscle cells were predominant in splenic veins and their cytoplasma had plentiful rough endoplasmic reticulum ribosomes and Golgi bodies. Along the vascular wall, a lot of collagen fibers were deposited, the intima was damaged and blood components accumulated. There was no significant difference in the expression of type Ⅰ procollagen mRNA in splenic venous wall between the patients with portal hypertension and those without

关键词： Portal hypertension Splanchnic hyperdynamic circulation Splanchnic vasculopathy

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Interfacial bonding mechanism of Cu/Al composite plate produced by corrugated cold roll bonding

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Rare Metals 2021年第5期40卷 1284-1293页

作者： Tao Wang Xiang-Yu Gao Zhi-Xiong Zhang Zhong-Kai Ren yan-yang qi Jing-Wei Zhao College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Engineering Research Center for Metal Composites Forming Process and Equipment Taiyuan University of TechnologyTaiyuan 030024China TYUT-UOW Joint Research Center Taiyuan University of TechnologyTaiyuan 030024China

Corrugated cold roll bonding(CCRB) produces metal composite plate with improved mechanical properties compared with conventional methods,but the interfacial mechanism is not fully ***,Cu/Al composite plate with good plate shape was produced by CCRB,and the bonding mechanism and strength along the corrugated interface were studied by experiments and finite element *** results showed that the average bonding strength of Cu/Al composite plate produced by CCRB was nearly twice that of conventional composite plate at an average reduction of 40% during *** friction shear stresses occurred at the interface of the corrugated composite plate,which promoted the plastic deformation of the metals and accelerated the rupture of the brittle interfacial *** backscattered diffraction analysis showed that higher degrees of grain elongation and refinement occurred in the matrices at the front waist and trough due to the stronger normal and shear ***-dispersive spectroscopy line scans showed that the thickest atomic diffusion layer occurred at the front *** present combination of experimental and computational analyses provides insights into the underlying mechanism of mechanically improved metal composites prepared by CCRB.

关键词： Corrugated cold roll bonding Cu/Al composite Bonding strength Friction shear stress Grain refinement Atomic diffusion layer

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The role of vascular endothelial growth factor in ossification

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International Journal of Oral Science 2012年第2期4卷 64-68页

作者： yan-qi yang Ying-Ying Tan Ricky Wong Alex Wenden Lin-Kun Zhang A bakr M Rabie Department of Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong China Unit Pakar Ortodontik Klinik Pergigian Poliklinik Komuniti Mak MandinMalaysia Department0fOrfhodonflcs Tlanj}nsfomafoI.gicalH.spJcaJ.iNankaiunIversityTianjinchinaand PrivatePracticeC0rrespondence:DrYQyang DepartmentDfOrthodonticsFacultyofDentIstryTheUnlversity硝HongKong34HospnalRoadHOngK0ngSARChinaE—maiJ=yan副anq@hkuhk

Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair. Vascular endothelial growth factor （VEGF） is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator durin~ these processes. It not only functions in bone an^io^enesis but also in various aspects of bone develooment.

关键词： endochondral ossification intramembranous ossification osteogenesis vascular endothelial growth factor

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Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

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Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： yang yang Zhi-Gang Liu yan-qi yang Zhi-Gang Zhang Xiao-Li Wang Yu-Long Li Rui-Fang Sun School of Public Health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of Pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various ***,a systematic pan-cancer analysis of TNFAIP6 is *** we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon ***:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor ***2 was used to evaluate the effect of TNFAIP6 on clinical cancer *** was used to assess TNFAIP6 *** correlation between TNFAIP6 and cancer immune infiltrates was explored using *** CancerSEA database was used to perform functional analysis of *** was used to identify TNFAIP6-related gene enrichment *** was performed to detect TNFAIP6 protein expression in the colon *** addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with ***:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer ***6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial ***6 and similar genes may also be involved in the PID_VEGF_VEGFR_*** revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer *** known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics *** results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.

关键词： Cancer IHC Mutation Survival TNFAIP6

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Clinical Characteristics and Prognosis of End-stage Hypertrophic Cardiomyopathy

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Chinese Medical Journal 2015年第11期128卷 1483-1489页

作者： yan Xiao Kun-qi yang yan-Kun yang Ya-Xin Liu Tao Tian Lei Song Xiong-Jing Jiang Xian-Liang Zhou Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： End-stage hypertrophic cardiomyopathy （HCM） is complicated by substantial adverse events. However, few studies have focused on electrocardiographic features and their prognostic values in HCM. This study aimed to evaluate the clinical manifestations and prognostic value of electrocardiography in patients with end-stage HCM. Methods： End-stage HCM patients were enrolled from a total of 1844 consecutive HCM patients from April 2002 to November 2013 at Fuwai Hospital. Clinical data, including medical history, electrocardiography, and echocardiography, were analyzed. Cox hazards regression analysis was used to assess the risk factors for cardiovascular mortality. Results： End-stage HCM was identified in 99 （5.4%） patients, averaged at 52 ± 16 years old at entry. Atrial fibrillation was observed in 53 patients and mural thrombus in 19 patients. During 3.9 ±3.0 years of follow-up, embolic stroke, refractory heart failure, and death or transplantation were observed in 20, 39, and 51 patients, respectively. The incidence of annual mortality was 13.2%. Multivariate Cox hazards regression analysis identified New York Heart Association Class （NYHA） Ill/IV at entry （hazard ratio [HR]： 1.99; 95% confidence interval [C/I： 1.05-3.80; P = 0.036）, left bundle branch block （LBBB）（HR： 2.80; 95% CI： 1.47-5.31; P = 0.002）, and an abnormal Q wave （HR： 2.21; 95% CI： 1.16-4.23; P = 0.016） as independent predictors of cardiovascular death, in accordance with all-cause death and heart failure-related death. Conclusions： LBBB and an abnormal Q wave are risk factors of cardiovascular mortality in end-stage HCM and provide new evidence for early intervention. Susceptibility of end-stage HCM patients to mural thrombus and embolic events warrants further attention.

关键词： End-stage Hypertrophic Cardiomyopathy Left Bundle Branch Block Prognosis Q wave

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Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong yang Haochen Shen Xiaoming Xiao Zhichao Li qi Zhou Wei yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

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变量核奇异积分和分数次微分加权范不等式

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数学学报（中文版） 2020年第4期63卷 381-396页

作者：杨沿奇陶双平西北师范大学数学与统计学院兰州730070

用T和Dγ(0≤γ≤1)分别表示变量核奇异积分和分数次微分算子.T*和T#分别为T的共轭算子及拟共轭算子.利用球调和多项式展式,本文得到了TDγ-DγT和(T*-T#)Dγ在Bωq,λ(Rn)上的有界性.同时也得到了变量核奇异积分的积T1T2和拟积T1■T2... 详细信息

用T和Dγ(0≤γ≤1)分别表示变量核奇异积分和分数次微分算子.T*和T#分别为T的共轭算子及拟共轭算子.利用球调和多项式展式,本文得到了TDγ-DγT和(T*-T#)Dγ在Bωq,λ(Rn)上的有界性.同时也得到了变量核奇异积分的积T1T2和拟积T1■T2的加权范不等式.

关键词：变量核奇异积分分数次微分加权λ-中心Morrey空间

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θ-型C-Z算子在加权变指数Morrey空间上的有界性

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数学学报（中文版） 2019年第3期62卷 503-514页

作者：杨沿奇陶双平西北师范大学数学与统计学院兰州730070

在满足一定的正则性假设条件下,建立了θ-型Calderón-Zygmund算子T_θ在一类变指数Lebesgue空间上的加权有界性.进一步得到了T_θ在加权变指数Herz空间和Herz-Morrey空间上的有界性.另外,还证明了相应的交换子[b,T_θ]在广义加权变指数... 详细信息

在满足一定的正则性假设条件下,建立了θ-型Calderón-Zygmund算子T_θ在一类变指数Lebesgue空间上的加权有界性.进一步得到了T_θ在加权变指数Herz空间和Herz-Morrey空间上的有界性.另外,还证明了相应的交换子[b,T_θ]在广义加权变指数Morrey空间上是有界的.

关键词： θ-型Calderón-Zygmund算子加权变指数Morrey空间加权变指数Herz-Morrey空间

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The VNP-PSO Method for Medical Image Registration

The VNP-PSO Method for Medical Image Registration

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第二十九届中国控制会议

作者： JIN Jing,WANG yan,WANG qi,yang Bao-qing Harbin Institute of Technology,Harbin 150001,P.R.China

In this paper,an improved variable neighborhood placing based particle swarm optimization（VNP-PSO） algorithm,which is cooperative and population-based global searching swarm intelligence mataheuristics,is ***,PSO has premature convergence property,which restricts its *** this in mind,the proposed VNP-PSO may lead the particles,which are determined as trapped into local optimum,out from their local minima to the global *** test the performances of VNP-PSO,experiments on four benchmark functions are conducted using the basic PSO and improved VNP-PSO ***,simulation on the optimization performances of VNP-PSO registering kidney ultrasonic image samples is *** experiment results demonstrate that the proposed VNP-PSO method is an accurate,efficient optimization method,and suitable for medical image registration.

关键词： Image Registration Particle Swarm Optimization Variable Neighborhood Placing

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重载货车驾驶人驾驶风格识别与量化研究

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交通运输系统工程与信息 2022年第4期22卷 137-148页

作者：覃文文鄢祺阳谷金晶李武戢晓峰昆明理工大学交通工程学院昆明650504 云南省现代物流工程研究中心昆明650504 同济大学电子与信息工程学院上海201804 大连理工大学建设工程学部辽宁大连116024

重载货车驾驶人的激进驾驶风格具有强烈的习惯性特征和风险性特征,一旦养成很难矫正,且极易诱发交通事故。针对现有研究极少关注重载货车驾驶人驾驶风格的不足,本文基于某全国货运监管平台提供的云南省重载货车低频轨迹数据,从风格聚类... 详细信息

重载货车驾驶人的激进驾驶风格具有强烈的习惯性特征和风险性特征,一旦养成很难矫正,且极易诱发交通事故。针对现有研究极少关注重载货车驾驶人驾驶风格的不足,本文基于某全国货运监管平台提供的云南省重载货车低频轨迹数据,从风格聚类、风格识别和风格评估这3个方面,提出综合考虑疲劳驾驶特征和超速驾驶特征的重载货车驾驶人驾驶风格分析方法。首先,基于轨迹数据蕴含驾驶人驾驶行为模式的特点,构建表征重载货车驾驶人驾驶风格的疲劳驾驶和超速驾驶特征集;其次,利用因子分析进行特征约简,并采用K-均值聚类方法划分重载货车驾驶人的驾驶风格;然后,构建基于支持向量机的驾驶风格识别模型,并与梯度提升决策树的识别结果进行对比;最后,基于疲劳驾驶特征和超速驾驶特征的累积分布,建立基于CRITIC(Criteria Importance Though Intercriteria Correlation)赋权法的重载货车驾驶人驾驶风格量化评估模型。研究结果表明:经过特征约简,提取的疲劳因子和超速因子能综合反映上述两类特征集80.838%的信息;根据疲劳因子和超速因子可将驾驶风格划分为4种类别,即稳健型、超速型、疲劳型和危险型,相应重载货车驾驶人比例依次为62.60%、25.02%、7.40%和4.98%;基于支持向量机的重载货车驾驶人驾驶风格识别模型对不同风格的识别准确率均大于97%,整体表现优于梯度提升决策树;基于CRITIC赋权法的驾驶风格评估模型能有效量化重载货车驾驶人的驾驶风格,其中稳健型驾驶人表现最好,75%以上的驾驶人风格评估总分高于60分;危险型驾驶人表现最差,75%以上的驾驶人风格评估总分低于20分。研究结果可为重载货车驾驶人不良驾驶行为的监测、干预和管理提供理论依据和技术支撑。

关键词：交通工程驾驶风格识别支持向量机重载货车轨迹数据

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