The role of vascular endothelial growth factor in ossification

作     者：Yan-Qi Yang Ying-Ying Tan Ricky Wong Alex Wenden Lin-Kun Zhang A bakr M Rabie 

作者机构：Department of Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong China Unit Pakar Ortodontik Klinik Pergigian Poliklinik Komuniti Mak MandinMalaysia Department0fOrfhodonflcsTlanj}nsfomafoI.gicalH.spJcaJ.iNankaiunIversityTianjinchinaand PrivatePracticeC0rrespondence:DrYQYangDepartmentDfOrthodonticsFacultyofDentIstryTheUnlversity硝HongKong34HospnalRoadHOngK0ngSARChinaE—maiJ=yan副anq@hkuhk 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2012年第4卷第2期

页      面：64-68页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

主　　题：endochondral ossification intramembranous ossification osteogenesis vascular endothelial growth factor 

摘      要：Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair. Vascular endothelial growth factor （VEGF） is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator durin~ these processes. It not only functions in bone an^io^enesis but also in various aspects of bone develooment.