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Perithyroidal hemorrhage caused by hydrodissection during radiofrequency ablation for benign thyroid nodules:Two case reports

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World Journal of Clinical Cases 2022年第29期10卷 10755-10762页

作者： Bo-Wen Zheng Tao Wu Zhi-Cheng Yao yan-ping ma Jie Ren Department of Medical Ultrasonics The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of General Surgery The Third Affiliated Hospital of Sun Yat-sen universityGuangzhou 510530Guangdong ProvinceChina

BACKGROUND Hydrodissection is a widely used technique during radiofrequency ablation(RFA)for benign thyroid nodules.Although it could effectively avoid thermal injury to the surrounding critical structures and achieve complete treatment,routine operation of the remaining needle could cause perithyroidal hemorrhage.In this report,we present 2 cases of perithyroidal hemorrhage during RFA caused by a hydrodissection needle,which have not been reported before.CASE SUMmaRY A 21-year-old female and a 45-year-old male were admitted for RFA for benign thyroid nodules.Considering that their nodules were adjacent to the recurrent laryngeal nerve,the needle used for hydrodissection was placed and remained between the dorsal capsule of the lateral lobe and the recurrent laryngeal nerve.During the procedure,active bleeding near the needle appeared on ultrasonography(US).Although moderate pressure was quickly applied to the neck for several minutes,contrast-enhanced US(CEUS)still showed an active hemorrhage.A radiofrequency electrode was placed at the bleeding point under the guidance of CEUS to stop the bleeding,and the procedure was finally confirmed to be successful by CEUS,without other complications.CONCLUSION Hydrodissection during RFA of benign thyroid nodules was associated with a risk of perithyroidal hemorrhage.The timely recognition of this acute hemorrhage could help in the timely control of the bleeding,and CEUS-guided ablation of the bleeding point could be useful.

关键词： Complication Hemorrhage Hydrodissection Radiofrequency ablation Benign thyroid nodules Case report

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Investigating the Effects of Para-methoxy Substitution in Sterically Enhanced Unsymmetrical Bis(arylimino)pyridine-cobalt Ethylene Polymerization Catalysts

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Chinese Journal of Polymer Science 2022年第3期40卷 266-279,I0007页

作者： Yi yan Shi-Fang Yuan Ming Liu Gregory A.Solan yan-ping ma Tong-Ling Liang Wen-Hua Sun Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of SciencesBeijing 100190China Department of Chemistry University of LeicesterUniversity RoadLeicester LE17RHUK State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

A group of five bis(arylimino)pyridine-cobalt(Ⅱ)chloride complexes,[2-{(2,6-(Ph_(2)CH)_(2)-4-MeOC_(6)H_(2))N=CMe}-6-(ArN=CMe)C_5 H_(3)N]CoCl_(2)(Ar=2,6-Me_(2)C_(6)H_(3)Co1,2,6-Et_(2)C_(6)H_(3)Co2,2,6-iPr_(2)C_(6)H_(3)Co3,2,4,6-Me_(3)C_(6)H_(2)Co4,2,6-Et_(2)-4-MeC_(6)H_(2)Co5),each containing one N-4-methoxy-2,6-dibenzhydrylphenyl group and one smaller sterically/electronically variable N-aryl group,have been synthesized in good yield(>71%)from the corresponding neutral terdentate nitrogen-donor precursor,L1-L5.All complexes have been characterized by^(1)H-NMR and FTIR spectroscopy with the former highlighting the paramagnetic nature of these cobaltous species and the unsymmetrical nature of the chelating ligand.The molecular structures of Co3 and Co4 emphasize the steric differences of the two inequivalent N-aryl groups and the distorted square pyramidal geometry about the metal centers.In the presence of maO or MmaO,Co1-Co5 collectively displayed high activities for ethylene polymerization producing high molecular weight polyethylenes that,in general,exhibited narrow dispersities(M_w/M_n values:2.12-4.07).Notably,the least sterically hindered Co1 when activated with maO was the most productive(6.92×10^(6)g_(PE)·mol^(-1)_((Co))·h^(-1))at an operating temperature of60℃.Conversely,the most sterically hindered Co3/MmaO produced the highest molecular weight polyethylene(M_w=6.29×10^(5)g·mol^(-1)).All the polymers displayed high linearity as demonstrated by their melting temperatures(>130℃)and their~1 H-and^(13)C-NMR spectra.By comparison of Co1 with its para-methyl,-chloro and-nitro counterparts,the presence of the para-methoxy substituent showed the most noticeable effect of enhancing the thermal stability of the catalyst.

关键词： Cobalt(II)precatalyst Ethylene polymerization High molecular weight polyethylene Electronic effects Thermal stability

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maximum Likelihood Estimation via Duality for Cell Probabilities Subject to Convex and Log-convex Constraints

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Acta mathematicae Applicatae Sinica 2014年第1期30卷 157-170页

作者： yan-ping ma School of Science Beijing Jiaotong University

This article proposes a method for fitting models subject to a convex and log-convex constraint on the probability vector of a product multinomial （binomial） distribution. We present an iterative algorithm for finding the restricted maximum likelihood estimates （MLEs） of the probability vector and show that the algorithm converges to the true solution. Some examples are discussed to illustrate the method.

关键词： convex cone duality cone I-projection log-convex constraint maximum likelihood estimation

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Dinuclear Nickel(Ⅱ) Chlorides Bearing N,N′-bis(5,6,7-trihydroquinolin-8-ylidene)-[1,1′-biphenyl]-4,4′-diamines: Synthesis and Ethylene Polymerization

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Chinese Journal of Polymer Science 2018年第2期36卷 207-213页

作者： yan-Ning Zeng Qi-Feng Xing yan-ping ma Wen-Hua Sun Laboratory of Engineering Plastics Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

5,6,7-Trihydroquinolin-8-one was condensed with the corresponding benzidine to give N,N′-bis（5,6,7-trihydroquinolin-8-ylidene）-[1,1′-biphenyl]-4,4′-diamine derivatives（L1–L3）. The ligands were reacted with two equivalents of Ni Cl2·6H2O in a mixture of Et OH and CH2Cl2 to afford the corresponding dinickel（II） chloride complexes（Ni1-Ni3）. The organic compounds were completely characterized, whilst the bi-metallic complexes were characterized by FTIR spectra and elemental analysis. These nickel complexes exhibited high activities towards ethylene polymerization in the presence of either maO or Me2AlCl, maintaining a high activity over a prolonged period. The obtained polyethylenes were confirmed as having low molecular weights by GPC analysis.

关键词： Dinuclear nickel complexes Ethylene polymerization Molecular weight Molecular weight distribution

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Formation of six-coordinated silicon in calcium phosphosilicate xerogels assisted by polyols at low temperature and pressure

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Chinese Chemical Letters 2015年第6期26卷 768-772页

作者： Ai-Ling Li yan-ping ma Dong Qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of Sciences

Silicon is usually found to be four-coordinated when neighbored with oxygen. Six-coordinated silicon is only seen in samples at very specific composition or made at high temperature/pressure. In this study, we managed to synthesize calcium phosphosilicate xerogels containing six-coordinated silicon with the help of polyols by sol-gel method, without the need of treatment at high temperature or high pressure. Both phosphorus precursors and polyols were found to be essential for the formation of six-coordinated silicon species; in the absence of either species, only normal four-coordinated silicon was observed under otherwise identical conditions. Samples containing six-coordinated silicon sites were found to release silicon species faster than those without six-coordinated silicon sites upon dissolved in water, suggesting that six-coordinated silicon species have higher reactivity toward hydrolysis.

关键词： Phosphosilicate Six-coordinated silicon PolyolsmaS-NMR

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Identification and characterization of a novel group of natural antisense transcripts from RNA1.2 gene locus of human cytomegalovirus

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Chinese Medical Journal 2019年第13期132卷 1591-1598页

作者： Bing-yang Liu yan-ping ma Ying Qi Yu-Jing Huang Zhong-yang Liu Meng-Qing Lu Qiang Ruan Department of Endocrinology Affiliated Shengjing HospitalChina Medical UniversityShenyangLiaoning 110004China Virus Laboratory Affiliated Shengjing HospitalChina Medical UniversityShenyangLiaoning 110004China

Background:Natural anti-sense transcripts(NATs),which are transcribed from the complementary DNA strand of annotated genes,exert regulatory function of gene expression.Increasing studies recognized anti-sense transcription widespread throughout human cytomegalovirus(HCMV)genome,whereas the anti-sense transcription of RNA1.2 gene locus has never been investigated.In this study,the transcription of the RNA1.2 anti-sense strand was investigated in clinically isolated HCMV strain.Methods:Strand-specific high-through RNA-sequencing(RNA-seq)was performed to find possible anti-sense transcripts(ASTs).For analyzing and visualization of RNA-seq data sets,Integrative Genomics Viewer software was applied.To confirm these possibilities,Northern blotting and rapid amplification of cDNA ends(RACE)were used.Results:Transcription of the opposite strand of RNA1.2 gene locus was detected by RNA-sequencing using RNAs extracted from human embryonic lung fibroblasts infected with HCMV clinical isolate HAN.At least three HCMV NATs,named RNA1.2 AST 1,RNA1.2 AST2,and RNA 1.2 AST3,were characterized by Northern blotting and RACE analyses.These RNA1.2 ASTs orientated from the complementary strand of RNA1.2 locus during the late phase of HCMV infection.The 5'-and 3'-termini of these transcripts were located within the opposite sequence of the predicted RNA1.2 gene.Conclusion:A cluster of novel NATs was transcribed from the opposite sequence of the HCMV RNA 1.2 gene region.

关键词： Human cytomegalovirus RNA1.2 Natural anti-sense transcript

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Silencing transformer and transformer-2 in Zeugodacus cucurbitae causes defective sex determination with inviability of most pseudomales

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Journal of Integrative Agriculture 2024年第3期23卷 938-947页

作者： Qin ma Zizhen Fan ping Wang Siya ma Jian Wen Fengqin Cao Xianwu Lin Rihui yan Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests of Ministry of Education School of Plant ProtectionHainan UniversityHaikou 570228China School of Life Sciences HainanUniversityHaikou 570228China Hainan Yazhou Bay Seed Lab Sanya 572000China

transformer is a switch gene for sex determination in many insects, which cooperates with transformer-2 that is expressed in both sexes to regulate female differentiation, particularly in dipterans. Zeugodacus cucurbitae(Coquillett) is a very destructive pest worldwide, however, its sex determination pathway remains largely uncharacterized. Here, we show that the female sex ratio is sharply reduced with knockdown of either transformer or transformer-2 by RNA interference in early embryos of Z. cucurbitae. Most of the males grown from the embryos with transient transformer and transformer-2 suppression mated with wild-type females and produced mixed sex progeny, with one exception that produced only female progeny, and all of the few remaining males failed to mate with wild-type females and produced no progeny. The exceptional male and those males with mating failure were XX pseudomales as determined by the detection of Y chromosome-linked maleness-on-the-Y, indicating that most XX pseudomales are not viable. The phenotypes of transformer and transformer-2 suggest that they play a key role in regulating sex determination and are required for female sexual development of Z. cucurbitae. Our results will be beneficial to the understanding of sex determination in Z. cucurbitae and can facilitate the development of genetic sexing strains for its biological control.

关键词： Zeugodacus cucurbitae transformer transformer-2 sex determination RNA interference biological control

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Genetic polymorphism of UL144 open reading frame of human cytomegalovirus DNA detected in colon samples from infants with Hirschsprung's disease

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World Journal of Gastroenterology 2007年第32期13卷 4350-4354页

作者： Zhi-Qin mao Ying Huang Mei Sun Qiang Ruan Ying Qi Rong He Yu-Jing Huang yan-ping ma Yao-Hua Ji Zheng-Rong Sun Hong Gao Department of Pediatrics Second Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China Department of Pediatric Surgery Second Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China Virus Laboratory Second Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China

AIM:To explore the genetic diversities of UL144 open reading frame (ORF) of cytomegalovirus DNA detected in colon tissue from infants with Hirschsprung's disease (HD) by sequencing UL144 DNA in 23 aganglionic colon tissue and 4 urine samples from 25 HD infants. METHODS:Nest PCR was performed for amplification of the UL144 gene. The UL144 gene was analyzed with softwares,such as DNAclub,BioEdit,PROSITE database,and DNAstar. RESULTS:The strains from HD patients were distributed among three genotypes of UL144:group 1A (64%),group 2 (24%),and group 3 (12%). The UL144 genotypes between strains from HD and control group were compared by chi square test (χ2 = 1.870,P = 0.393). Strains from the colon were sporadically distributed in UL144 genotypes. CONCLUSION:There are genetic diversities of UL144 ORF in colon tissue of infants with HD. However,cytomegalovirus UL144 genotypes are not associated with clinical manifestations of HD.

关键词：多态现象细胞巨化病毒先天性巨结肠巨细胞病毒基因

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An adaptive energy regulation in a memristive map linearized from a circuit with two memristive channels

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Communications in Theoretical Physics 2024年第3期76卷 42-50页

作者： Feifei yang ping Zhou Jun ma School of Science Chongqing University of Posts and TelecommunicationsChongqing 430065China College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China

Nonlinear circuits can show multistability when a magnetic flux-dependent memristor(MFDM) or a charge-sensitive memristor(CSM) is incorporated into a one branch circuit,which helps estimate magnetic or electric field effects.In this paper,two different kinds of memristors are incorporated into two branch circuits composed of a capacitor and a nonlinear resistor,thus a memristive circuit with double memristive channels is designed.The circuit equations are presented,and the dynamics in this oscillator with two memristive terms are discussed.Then,the memristive oscillator is converted into a memristive map by applying linear transformation on the sampled time series for the memristive oscillator.The Hamilton energy function for the memristive oscillator is obtained by using the Helmholtz theorem,and it can be mapped from the field energy of the memristive circuit.An energy function for the dual memristive map is suggested by imposing suitable weights on the discrete energy function.The dynamical behaviors of the new memristive map are investigated,and an adaptive law is proposed to regulate the firing mode in the memristive map.This work will provide a theoretical basis and experimental guidance for oscillator-to-map transformation and discrete map energy calculation.

关键词： Hamilton energy dual memristive map adaptive energy regulation

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Channel assignment and power allocation for throughput improvement with PPO in B5G heterogeneous edge networks

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Digital Communications and Networks 2024年第1期10卷 109-116页

作者： Xiaoming He Yingchi mao Yinqiu Liu ping ping yan Hong Han Hue The Collge of Computer and Information Hohai UniversityNanjingChina The Key Laboratory of Water Big Data Technology of Ministy of Water Resources Hohai UniversityNanjng China The School of Computer Science and Engineering Nanyang Technological UniversitySingapore The College of Textile and Clothing Engineering Soochow UniversitySuzhouChina The College of Internet of Things Nanjing University of Posts and TelecommunicationsNanjingChina

In Beyond the Fifth Generation(B5G)heterogeneous edge networks,numerous users are multiplexed on a channel or served on the same frequency resource block,in which case the transmitter applies coding and the receiver uses interference cancellation.Unfortunately,uncoordinated radio resource allocation can reduce system throughput and lead to user inequity,for this reason,in this paper,channel allocation and power allocation problems are formulated to maximize the system sum rate and minimum user achievable rate.Since the construction model is non-convex and the response variables are high-dimensional,a distributed Deep Reinforcement Learning(DRL)framework called distributed Proximal Policy Optimization(PPO)is proposed to allocate or assign resources.Specifically,several simulated agents are trained in a heterogeneous environment to find robust behaviors that perform well in channel assignment and power allocation.Moreover,agents in the collection stage slow down,which hinders the learning of other agents.Therefore,a preemption strategy is further proposed in this paper to optimize the distributed PPO,form DP-PPO and successfully mitigate the straggler problem.The experimental results show that our mechanism named DP-PPO improves the performance over other DRL methods.

关键词： B5G Heterogeneous edge networks PPO Channel assignment Power allocation Throughput

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