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Acupuncture for obesity and related diseases:Insight for regulating neural circuit

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Journal of Integrative Medicine 2024年第2期22卷 93-101页

作者： lin-yan jiang Jun Tian Ya-nan yang Shao-hui Jia Qing Shu Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071Hubei ProvinceChina School of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Department of Traditional Chinese Medicine China Resources&Wu Gang General HospitalWuhan 430080Hubei ProvinceChina

Obesity is defined as abnormal or excessive fat accumulation that may impair *** is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related *** comorbidities comprise a significant public health *** anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and *** treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side ***,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural *** this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was *** on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

关键词： Obesity Acupuncture Neural circuit Appetite Energy metabolism

Hydrogel-exosome system in tissue engineering:A promising therapeutic strategy

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Bioactive Materials 2024年第8期38卷 1-30页

作者： Ming-Hui Fan Jin-Kui Pi Chen-Yu Zou yan-lin jiang Qian-Jin Li Xiu-Zhen Zhang Fei Xing Rong Nie Chen Han Hui-Qi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041PR China Core Facilities West China HospitalSichuan UniversityChengduSichuan610041PR China Frontier Medical Center Tianfu Jincheng LaboratoryChengduSichuan610212PR China

Characterized by their pivotal roles in cell-to-cell communication,cell proliferation,and immune regulation during tissue repair,exosomes have emerged as a promising avenue for“cell-free therapy”in clinical ***,possessing commendable biocompatibility,degradability,adjustability,and physical properties akin to biological tissues,have also found extensive utility in tissue engineering and regenerative *** synergistic combination of exosomes and hydrogels holds the potential not only to enhance the efficiency of exosomes but also to collaboratively advance the tissue repair *** review has summarized the advancements made over the past decade in the research of hydrogel-exosome systems for regenerating various tissues including skin,bone,cartilage,nerves and tendons,with a focus on the methods for encapsulating and releasing exosomes within the *** has also critically examined the gaps and limitations in current research,whilst proposed future directions and potential applications of this innovative approach.

关键词： Exosome Hydrogel Tissue engineering Regenerative medicine

Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage

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Neural Regeneration Research 2023年第6期18卷 1308-1315页

作者： Zi-Xian Zhou Qi Cui Ying-Mei Zhang Jia-Xin yang Wen-Jing Xiang Ning Tian yan-lin jiang Mei-ling Chen Bin yang Qing-Hua Li Ru-Jia Liao Laboratory of Neuroscience Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Neurology Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Guangxi Clinical Research Center for Neurological Diseases Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Pharmacology Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina

Recent studies have indicated that suppressing oxidative stress and ferroptosis can considerably improve the prognosis of intracerebral hemorrhage(ICH).Withaferin A(WFA),a natural compound,exhibits a positive effect on a number of neurological ***,the effects of WFA on oxidative stress and ferroptosis-mediated signaling pathways to ICH remain *** this study,we investigated the neuroprotective effects and underlying mechanism for WFA in the regulation of ICH-induced oxidative stress and *** established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced *** was injected intracerebroventricularly at 0.1,1 or 5μg/kg once daily for 7 days,starting immediately after ICH *** markedly reduced brain tissue injury and iron deposition and improved neurological function in a dose-dependent manner 7 days after cerebral *** in vitro experiments,cell viability test showed that WFA protected SH-SY5Y neuronal cells against hemin-induced cell ***-linked immunosorbent assays in vitro and in vivo showed that WFA markedly decreased the level of malondialdehyde,an oxidative stress marker,and increased the activities of anti-oxidative stress markers superoxide dismutase and glutathione peroxidase after *** blot assay,quantitative polymerase chain reaction and immunofluorescence results demonstrated that WFA activated the nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling axis,promoted translocation of Nrf2 from the cytoplasm to nucleus,and increased HO-1 *** Nrf2 with siRNA completely reversed HO-1 expression,oxidative stress and protective effects of ***,WFA reduced hemin-induced ***,after treatment with an HO-1 inhibitor,the neuroprotective effects of WFA against hemin-induced ferroptosis were *** test results showed that WFA combined with ferrostatin-1

关键词： behavior brain injuries hemorrhagic stroke ferroptosis heme oxygenase-1 neuroprotection nuclear factor E2-related factor 2 nuclear translocator oxidative stress stroke

Procyanidins-crosslinked small intestine submucosa: A bladder patch promotes smooth muscle regeneration and bladder function restoration in a rabbit model

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Bioactive Materials 2021年第6期6卷 1827-1838页

作者： Xiu-Zhen Zhang yan-lin jiang Jun-Gen Hu Long-Mei Zhao Qiu-Zhu Chen yan Liang Yi Zhang Xiong-Xin Lei Rui Wang Yi Lei Qing-Yi Zhang Jesse Li-ling Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuanChina Research Core Facility of West China Hospital Sichuan UniversityChengduSichuanChina

Currently the standard surgical treatment for bladder defects is augmentation cystoplasty with autologous tissues,which has many side *** such as small intestine submucosa(SIS)can provide an alternative scaffold for the repair as bladder *** studies have shown that SIS could enhance the capacity and compliance of the bladder,but its application is hindered by issues like limited smooth muscle regeneration and stone formation since the fast degradation and poor mechanical properties of the ***(PC),a natural bio-crosslinking agent,has shown anti-calcification,anti-inflammatory and anti-oxidation *** importantly,PC and SIS can crosslink through hydrogen bonds,which may endow the material with enhanced mechanical property and stabilized *** this study,various concentrations of PC-crosslinked SIS(PC-SIS)were prepared to repair the full-thickness bladder defects,with an aim to reduce complications and enhance bladder *** vitro assays showed that the crosslinking has conferred the biomaterial with superior mechanical property and anti-calcification property,ability to promote smooth muscle cell adhesion and upregulate functional genes *** a rabbit model with bladder defects,we demonstrated that the PC-SIS scaffold can rapidly promote in situ tissue regrowth and regeneration,in particular smooth muscle remodeling and improvement of urinary *** PC-SIS scaffold has therefore provided a promising material for the reconstruction of a functional bladder.

关键词： Bladder reconstruction Small intestinal submucosa Procyanidins Bio-crosslinking Smooth muscle regeneration

Magnetic activity and orbital parameters of CC Com based on photometric data,LAMOST low-and medium-resolution spectra

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Research in Astronomy and Astrophysics 2021年第4期21卷 129-138页

作者： Zhong-Zhong Zhu Li-Yun Zhang Gang Meng Yao Cheng Liu Long Xianming L.Han Qing-Feng Pi lin-yan jiang College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China College of Physics Guizhou UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Public Big Data Guizhou UniversityGuiyang 550025China Dept of Physics and AstronomyButler UniversityIndianapolisIN 46208USA College of Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this paper,we present four sets of photometric VRI light curves,and several LAMOST low and medium resolution spectra of contact binary CC *** revised the orbital parameters by simultaneously combining with previously published radial velocity measurements using the WilsonDevinney *** used light curves at different observational times to obtain the starspot *** values of the starspot radius are variable in short-and long-term scales,and their longitudes are *** updated the orbital period change of CC Com,and analyzed the periodic *** period of CC Com decreases at a rate of 4.66(±0.20)×10^(-11)d yr^(-1),which may be due to mass transfer from the secondary component to the primary *** oscillation of its orbital period with a period of17.18(0.08)years and amplitude of 0.0018(1)d may be caused by the light time effect(LITE)via a third body of 0.06 M☉dwarf or magnetic activity ***,we obtained one optical spectrum from the LAMOST survey,which gives the spectral type of CC Com as K7±2 *** emissions exist in the Ha,and Ca 11 H&K lines in the observed spectrum,indicating strong chromospheric activity on CC *** the 12 LAMOST medium-resolution spectra,the EWs of Ha line are variable along the phase and time,which may be a plage or flare event.

关键词： binaries:magnetic activity stars:eclipsing stars:individual(CC Com)

A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability,extracellular matrix-inducing bioactivity and function preservation

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Bioactive Materials 2023年第6期24卷 54-68页

作者： Chen-Yu Zou Juan-Juan Hu Dan Lu Qian-Jin Li yan-lin jiang Rui Wang Hai-yang Wang Xiong-Xin Lei Jesse Li-ling Hui yang Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041PR China Department of Otolaryngology Head and Neck SurgeryWest China HospitalSichuan UniversityChengduSichuan610041PR China Department of Medical Genetics West China Second HospitalSichuan UniversityChengduSichuan610041PR China

Injection laryngoplasty with biomaterials is an effective technique to treat glottic ***,the inadequate durability,deficient pro-secretion of extracellular matrix(ECM)and poor functional preservation of current biomaterials have yielded an unsatisfactory therapeutic ***,a self-fusing bioactive hydrogel comprising modified carboxymethyl chitosan and sodium alginate is developed through a dual-crosslinking mechanism(photo-triggered and dynamic covalent bonds).Owing to its characteristic networks,the synergistic effect of the hydrogel for vocal folds(VFs)vibration and phonation is adequately ***,owing to its inherent bioactivity of polysaccharides,the hydrogel could significantly enhance the secretion of major components(type I/III collagen and elastin)in the lamina propria of the VFs both in vivo and in *** a rabbit model for glottic insufficiency,the optimized hydrogel(C1A1)has demonstrated a durability far superior to that of the commercially made hyaluronic acid(HA)*** importantly,owing to the ECM-inducing bioactivity,the physiological functions of the VFs treated with the C1A1 hydrogel also outperformed that of the HA Gel,and were similar to those of the normal *** together,through a simple-yet-effective strategy,the novel hydrogel has demonstrated outstanding durability,ECM-inducing bioactivity and physiological function preservation,therefore has an appealing clinical value for treating glottic insufficiency.

关键词： Glottic insufficiency Self-fusion Hydrogel Extracellular matrix Physiological function

Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

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Bioactive Materials 2022年第10期7卷 388-402页

作者： Chen-Yu Zou Xiong-Xin Lei Juan-Juan Hu yan-lin jiang Qian-Jin Li Yu-Ting Song Qing-Yi Zhang Jesse Li-ling Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041PR China Department of Otolaryngology Head and Neck SurgeryWest China HospitalSichuan UniversityChengdu610041PR China Department of Medical Genetics West China Second HospitalSichuan UniversityChengdu610041PR China

Bio-adhesive polysaccharide-based hydrogels have attracted much attention in first-aid hemostasis and wound healing for excellent biocompatibility,antibacterial property and pro-healing ***,the inadequate mechanical properties and bio-adhesion limit their ***,based on dynamic covalent bonds,photo-triggered covalent bonds and hydrogen bonds,multifunctional bio-adhesive hydrogels comprising modified carboxymethyl chitosan,modified sodium alginate and tannic acid are ***-crosslinking strategy endows hydrogels with improved strength and flexibility *** to cohesion enhancement strategy and self-healing ability,considerable bio-adhesion is presented by the hydrogel with a maximal adhesion strength of 162.6 kPa,12.3-fold that of commercial fibrin *** on bio-adhesion and pro-coagulant activity(e.g.,the stimulative aggregation and adhesion of erythrocytes and platelets),the hydrogel reveals superior hemostatic performance in rabbit liver injury model with blood loss of 0.32 g,only 54.2%of that in fibrin *** healing efficiency of hydrogel for infected wounds is markedly better than commercial EGF Gel and Ag+Gel due to the enhanced antibacterial and antioxidant *** the multi-crosslinking strategy,the hydrogels show enhanced mechanical properties,fabulous bio-adhesion,superior hemostatic performance and promoting healing ability,thereby have an appealing application value for the first-aid hemostasis and infected wound healing.

关键词： Bio-adhesion First-aid hemostasis Infected wound healing Polysaccharide-based hydrogel Tannic acid

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng jiang Junshan Zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Multifunctional two-component in-situ hydrogel for esophageal submucosal dissection for mucosa uplift,postoperative wound closure and rapid healing

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Bioactive Materials 2023年第9期27卷 461-473页

作者： Xiong-Xin Lei Juan-Juan Hu Chen-Yu Zou yan-lin jiang Long-Mei Zhao Xiu-Zhen Zhang Ya-Xing Li An-Ni Peng Yu-Ting Song Li-Ping Huang Jesse Li-ling Hui-Qi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Otolaryngology Head and Neck SurgeryWest China HospitalSichuan UniversityChengduSichuan610041China Institute of Biomedical Engineering and Informatics Ilmenau University of TechnologyGustav-Kirchh Off Str.298693IlmenauGermany Department of Medical Genetics West China Second HospitalSichuan UniversityChengduSichuan610041China

Endoscopic submucosal dissection (ESD) for gastrointestinal tumors and premalignant lesions needs submucosal fluid cushion (SFC) for mucosal uplift before dissection, and wound care including wound closure and rapid healing postoperatively. Current SFC materials as well as materials and/or methods for post-ESD wound care have single treatment effect and hold corresponding drawbacks, such as easy dispersion, short duration, weak hemostasis and insufficient repair function. Thus, designing materials that can serve as both SFC materials and wound care is highly desired, and remains a challenge. Herein, we report a two-component in-situ hydrogel prepared from maleimide-based oxidized sodium alginate and sulfhydryl carboxymethyl-chitosan, which gelated mainly based on "click" chemistry and Schiff base reaction. The hydrogels showed short gelation time, outstanding tissue adhesion, favorable hemostatic properties, and good biocompatibility. A rat subcutaneous ultrasound model confirmed the ability of suitable mucosal uplift height and durable maintenance time of AM solution. The in vivo/in vitro rabbit liver hemorrhage model demonstrated the effects of hydrogel in rapid hemostasis and prevention of delayed bleeding. The canine esophageal ESD model corroborated that the in-situ hydrogel provided good mucosal uplift and wound closure effects, and significantly accelerated wound healing with accelerating re-epithelization and ECM remodeling post-ESD. The two-component in-situ hydrogels exhibited great potential in gastrointestinal tract ESD.

关键词： Hydrogel Endoscopic submucosal dissection Mucosa uplift Tissue sealant Wound healing