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Gefapixant,a Novel P2X3 Antagonist,Protects against Post Myocardial Infarction Cardiac Dysfunction and Remodeling Via Suppressing NLRP3 Inflammasome

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Current Medical Science 2023年第1期43卷 58-68页

作者： yan-zhao WEI Shuang yanG Wei LI yan-hong tang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan430060China Cardiovascular Research Institute Wuhan UniversityWuhan430060China Hubei Key Laboratory of Cardiology Wuhan430060China Department of Cardiology Wuhan No.1 HospitalWuhan Hospital of Traditional Chinese and Western MedicineWuhan430022China

Objective The ATP responsive P2 purinergic receptors can be subdivided into metabotropic P2X family and ionotropic P2Y *** these,P2X3 is a type of P2X receptor which is specifically expressed on nerves,especially on pre-ganglionic sensory *** study investigates whether gefapixant possesses the potential of inhibiting cardiac sympathetic hypersensitivity to protect against cardiac remodeling in the context of myocardial *** The Sprague-Dawley rats were divided randomly into three groups:sham group-myocardial infarction group,and myocardial infarction with gefapixant treatment *** infarction was induced by left anterior descending branch *** gefapixant solution was intraperitoneally injected each time per day for 7 days and the appropriate dosage of gefapixant was determined according to the results of hematoxylin-eosin(HE)staining and myocardial injury *** of cardiac function were assessed by echocardiograph and cardiac fibrosis was evaluated by Western blotting and immunofluorescence staining of collagen I and collagen *** sympathetic innervation was detected by norepinephrine concentration(pg/mL),in-vivo electrophysiology,and typical sympathetic *** cell infiltration was shown from immunofluorescence staining and pro-inflammatory signaling pathway activation was checked by immunohistology,quantitative realtime PCR(qPCR)and Western *** It was found that gefapixant injection of 10 mg/kg per day had the highest dosage-efficacy ***,gefapixant treatment improved cardiac pump function as shown by increased LVEF and LVFS,and decreased LVIDd and *** expression levels of collagen I and collagen III,and TNF-αwere all decreased by P2X3 ***,the decreased activation of nucleotide-binding and oligomerization domain-like receptors family pyrin-domain-containing 3(NLRP3)inflammasome and subsequent cleavage of caspase-1 which modula

关键词： myocardial infarction P2X3 inhibition gefapixant nucleotide-binding and oligomerization domain-like receptors family pyrin-domain-containing 3 inflammasome sympathetic nerve

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Predicting submerged vegetation drag with a machine learning-based method

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Journal of Hydrodynamics 2024年第3期36卷 534-545页

作者： Meng-yang Liu hong-wu tang Sai-yu Yuan Jing yan College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China Key Laboratory of Hydrologic-Cycle and Hydrodynamic-System of Ministry of Water Resources Hohai UniversityNanjing210098China

Accurate estimation of the drag forces generated by vegetation stems is crucial for the comprehensive assessment of the impact of aquatic vegetation on hydrodynamic processes in aquatic *** coupling relationship between vegetation layer flow velocity and vegetation drag makes precise prediction of submerged vegetation drag forces particularly *** present study utilized published data on submerged vegetation drag force measurements and employed a genetic programming(GP)algorithm,a machine learning technique,to establish the connection between submerged vegetation drag forces and flow and vegetation *** using the bulk velocity,U,as the reference velocity scale to define the drag coefficient,C_(d),and stem Reynolds number,the GP runs revealed that the drag coefficient of submerged vegetation is related to submergence ratio(H^(*)),aspect ratio(d^(*)),blockage ratio(ψ^(*)),and vegetation density(λ).The relation between vegetation stem drag forces and flow velocity is implicitly embedded in the definition of C_(d).Comparisons with experimental drag force measurements indicate that using the bulk velocity as the reference velocity,as opposed to using the vegetation layer average velocity,U_(v),eliminates the need for complex iterative processes to estimate U_(v)and avoids introducing additional errors associated with U_(v)*** approach significantly enhances the model’s predictive capabilities and results in a simpler and more user-friendly formula expression.

关键词： Drag coefficient genetic programming algorithm submerged vegetation flow resistance cylinder array

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Synthesis and curing of a novel amino-containing phthalonitrile derivative

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Chinese Chemical Letters 2007年第5期18卷 523-526页

作者： Ke Zeng Ke Zhou Wen Rui tang yan tang hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang yang State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University Chengdu 610065 China

A novel phthalonitrile derivative containing an amino group, 3,5-bis（3,4-dicyanophenoxy）aniline （CPA）, was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra （FT-IR） and nuclear magnetic resonance （^1H NMR）. Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance.

关键词： Phthalonitrfle derivative Amino group Self-promotion curing behavior

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Effect of Shensong yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity

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Chinese Medical Journal 2017年第2期130卷 171-178页

作者： hong-Yi Zhao Shu-Di Zhang Kai Zhang Xi Wang Qing-yan Zhao Shu-Juan Zhang Zi-Xuan Dai Yong-Sheng Qian You-Jing Zhang Hao-Tian Wei yan-hong tang Cong-Xin Huang Department of Cardiology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Cardiovascular Research Institute Wuhan University Wuhan Hubei 430060 China Hubei Key Laboratory of Cardiology Wuhan Hubei 430060 China Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Oncology The Affiliated Hospital of Guizhou Medical University Guiyang Guizhou 550000 China

Background： Shensong yangxin （SSYX）, a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation （AF） is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity. Methods： Eighteen mongrel dogs were randomly divided into control group （n = 6）, pacing group （n = 6）, and pacing ＋ SSYX group （n = 6）. The control group was implanted with pacemakers without pacing; the pacing group was implanted with pacemakers with long-term intermittent atrial pacing; the pacing ＋ SSYX group underwent long-term intermittent atrial pacing and SSYX oral administration. Results： Compared to the pacing group, the parameters of heart rate variability were lower after 8 weeks in the pacing ＋ SSYX group （low-frequency [LF] component： 20.85± 3.14 vs. 15.3±1.89 ms2, P =0.004; LF component/high-frequency component： 1.34 ± 0.33 vs. 0.77± 0.15, P 〈 0.001 ）. The atrial effective refractory period （AERP） was shorter and the dispersion of the AERP was higher after 8 weeks in the pacing group, while the changes were suppressed by SSYX intake. The dogs in the pacing group had more episodes and longer durations of AF than that in the pacing ＋ SSYX group. SSYX markedly inhibited the increase in sympathetic nerves and upregulation of tumor necrosis factor-alpha and interleukin-6 expression in the pacing ＋ SSYX group. Furthermore, SSYX suppressed the decrease of acetylcholine and α7 nicotinic acetylcholine receptor protein induced by long-term intermittent atrial pacing. Conclusions： SSYX substantially prevents atrial electrical remodeling and the progression of AF. These effects of SSYX may have association with regulating the imbalance of autonomic nerve activity and the cholinergic anti-inflammatory pathway.

关键词： Atrial Fibrillation Autonomic Nerve Cholinergic Anti-inflammatory Pathway Inflammatory Cytokines Shensongyangxin

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Contemporary characteristics,management,and outcomes of patients hospitalized for atrial fibrillation in China:results from the real-world study of Chinese atrial fibrillation registry

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Chinese Medical Journal 2020年第23期133卷 2883-2884页

作者： Qing-yan Zhao Shao-Bo Shi He Huang hong Jiang Bo yang Gang Wu Ming-Wei Bao Yu Liu yan-hong tang Xi Wang Shu Zhang De-Jia Huang Yong Huo Jun-Bo Ge Cong-Xin Huang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Cardiovascular Research Institute of Wuhan University WuhanHubei 430060China Hubei Key Laboratory of Cardiology WuhanHubei 430060China State Key Laboratory of Cardiovascular Disease Arrhythmia CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610000China Department of Cardiology Peking University First HospitalBeijing 100005China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China

Atrial fibrillation(AF)is a growing public health problem in the context of the epidemiologic transition from communicable to non-communicable diseases,and a high prevalence of AF was found in Chinese patients who died in hospital.[1]Indeed,most understanding of AF is based on findings from clinical trials and observational studies performed in North America and Western Europe,[2]and some studies have described the characteristics of patients with AF in other *** data have highlighted the important differences in the clinical characteristics and treatment of patients with AF in these regions.[3,4]However,few studies have investigated the characteristics of patients with AF in ***,the aim of this study was to investigate the clinical demographics,management,and outcomes of patients hospitalized for AF using data from a recently registered AF-specific nationwide cohort study in China,the real-world study of Chinese atrial fibrillation(RWS-CAF)*** RWS-CAF registry(registration number:ChiCTR1900021250)comprises a multicenter,observational,prospective cohort that includes consecutive patients requiring hospitalization with a diagnosis of AF made according to the Chinese AF guidelines,spanning from November 1,2017,to October 31,*** of the enrolled hospitals are grade A class three *** patients hospitalized with AF who were aged 18 years or older were recruited.

关键词： patients fibrillation atrial

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Model-driven path planning for robotic plasma cutting of branch pipe with single Y-groove based on pipe-rotating scheme

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Advances in Manufacturing 2024年第1期12卷 94-107页

作者： yan Liu Qiu tang Xin-Cheng Tian School of Control Science and Engineering Shandong UniversityJinan250061People’s Republic of China Engineering Research Center of Intelligent Unmanned System Ministry of EducationJinan250061People’s Republic of China School of Mechanical and Electronic Engineering Shandong Jianzhu UniversityJinan250101People’s Republic of China

The automatic cutting of intersecting pipes is a challenging task in *** improved automation and accuracy,this paper proposes a model-driven path planning approach for the robotic plasma cutting of a branch pipe with a single ***,it summarizes the intersection forms and introduces a dual-pipe intersection *** on this model,the moving three-plane structure(a description unit of the geometric characteristics of the intersecting curve)is constructed,and a geometric model of the branch pipe with a single Y-groove is ***,a novel mathematical model for plasma radius and taper compensation is ***,the compensation model and groove model are integrated by establishing movable ***,to prevent collisions between the plasma torch and workpiece,the torch height is planned and a branch pipe-rotating scheme is *** the established models and moving frames,the planned path description of cutting robot is provided in this novel *** accuracy of the proposed method is verified by simulations and robotic cutting experiments.

关键词： Automatic groove cutting of intersecting pipes Model-driven robot path planning Plasma beam radius and taper compensation

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Analyzing topics in social media for improving digital twinning based product development

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Digital Communications and Networks 2024年第2期10卷 273-281页

作者： Wenyi tang Ling Tian Xu Zheng Ke yan School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product *** efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital *** work mines real-world consumer feedbacks through social media topics,which is significant to product *** specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a *** primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset ***,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse *** this end,this work combines deep learning and survival analysis to predict the prevalent time of *** propose a specialized deep survival model which consists of two *** first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network ***,a specific loss function different from regular survival models is proposed to achieve a more reasonable *** experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods.

关键词： Digital twinning Product development Topic analysis Social media

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The Structure Entropy of Social Networks

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Journal of Systems Science & Complexity 2024年第3期37卷 1147-1162页

作者： LI Zhenpeng yan Zhihua yanG Jian tang Xijin School of Electronics and Information Engineering Taizhou UniversityLinhai 317000China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Yunnan Key Laboratory of Smart City in Cyberspace Security Yuxi Normal UniversityYuci 653100China University of Chinese Academy of Sciences Beijing 100039China

Micro triadic structure is an important motif and serves the building block of complex *** this paper,the authors define structure entropy for a social network and explain this concept by using the coded triads proposed by Davis and Leinhardt in *** proposed structure entropy serves as a new macro-evolution index to measure the network’s stability at a given *** analysis of real-world network structure entropy discloses rich information on the mechanism that yields given triadic motifs frequency *** paper illustrates the intrinsic link between the micro dyadic/triadic motifs and network structure ***,the authors find that the high proportion of reciprocity and transitivity results in the emergence of hierarchy,order,and cooperation of online social networks.

关键词： Dyadic and triadic motifs network structure entropy reciprocity and transitivity

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Positive definiteness of real quadratic forms resulting from the variable-step L1-type approximations of convolution operators

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Science China Mathematics 2024年第2期67卷 237-252页

作者： hong-Lin Liao Tao tang Tao Zhou School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Division of Science and Technology BNU-HKBU United International CollegeZhuhai 519087China SUSTech International Center for Mathematics Shenzhen 518055China NCMIS&LSEC Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

The positive definiteness of real quadratic forms with convolution structures plays an important rolein stability analysis for time-stepping schemes for nonlocal operators. In this work, we present a novel analysistool to handle discrete convolution kernels resulting from variable-step approximations for convolution *** precisely, for a class of discrete convolution kernels relevant to variable-step L1-type time discretizations, weshow that the associated quadratic form is positive definite under some easy-to-check algebraic conditions. Ourproof is based on an elementary constructing strategy by using the properties of discrete orthogonal convolutionkernels and discrete complementary convolution kernels. To our knowledge, this is the first general result onsimple algebraic conditions for the positive definiteness of variable-step discrete convolution kernels. Using theunified theory, we obtain the stability for some simple nonuniform time-stepping schemes straightforwardly.

关键词： discrete convolution kernels positive definiteness variable time-stepping orthogonal convolution kernels complementary convolution kernels

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Distributed algorithm for solving variational inequalities over time-varying unbalanced digraphs

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Control Theory and Technology 2024年第3期22卷 431-441页

作者： Yichen Zhang Yutao tang Zhipeng Tu Yiguang hong School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China Network Technology Laboratory Huawei Technologies Co.Ltd.Beijing 100095China Department of Control Science and Engineering Tongji UniversityShanghai 200092China Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China

In this paper,we study a distributed model to cooperatively compute variational inequalities over time-varying directed ***,each agent has access to a part of the full mapping and holds a local view of the global set *** virtue of an auxiliary vector to compensate the graph imbalance,we propose a consensus-based distributed projection algorithm relying on local computation and communication at each *** show the convergence of this algorithm over uniformly jointly strongly connected unbalanced digraphs with nonidentical local *** also provide a numerical example to illustrate the effectiveness of our algorithm.

关键词： Variational inequality Distributed computation Multi-agent system Weight-unbalanced graph

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