Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity

作     者：Hong-Yi Zhao Shu-Di Zhang Kai Zhang Xi Wang Qing-Yan Zhao Shu-Juan Zhang Zi-Xuan Dai Yong-Sheng Qian You-Jing Zhang Hao-Tian Wei Yan-Hong Tang Cong-Xin Huang Zhao Hong-Yi;Zhang Shu-Di;Zhang Kai;Wang Xi;Zhao Qing-Yan;Zhang Shu-Juan;Dai Zi-Xuan;Qian Yong-Sheng;Zhang You-Jing;Wei Hao-Tian;Tang Yan-Hong;Huang Cong-Xin

作者机构：Department of Cardiology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Cardiovascular Research Institute Wuhan University Wuhan Hubei 430060 China Hubei Key Laboratory of Cardiology Wuhan Hubei 430060 China Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Oncology The Affiliated Hospital of Guizhou Medical University Guiyang Guizhou 550000 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2017年第130卷第2期

页      面：171-178页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：TheNationalScienceandTechnologyPillarProgramofChina(No.2011BAI11B12) TheNationalKeyBasicResearchDevelopmentProgramofChina(The"973"Program,No.2012CB518604) 

主　　题：Atrial Fibrillation Autonomic Nerve Cholinergic Anti-inflammatory Pathway Inflammatory Cytokines ShensongYangxin 

摘      要：Background： Shensong Yangxin （SSYX）, a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation （AF） is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity. Methods： Eighteen mongrel dogs were randomly divided into control group （n = 6）, pacing group （n = 6）, and pacing ＋ SSYX group （n = 6）. The control group was implanted with pacemakers without pacing; the pacing group was implanted with pacemakers with long-term intermittent atrial pacing; the pacing ＋ SSYX group underwent long-term intermittent atrial pacing and SSYX oral administration. Results： Compared to the pacing group, the parameters of heart rate variability were lower after 8 weeks in the pacing ＋ SSYX group （low-frequency [LF] component： 20.85± 3.14 vs. 15.3±1.89 ms2, P =0.004; LF component/high-frequency component： 1.34 ± 0.33 vs. 0.77± 0.15, P 〈 0.001 ）. The atrial effective refractory period （AERP） was shorter and the dispersion of the AERP was higher after 8 weeks in the pacing group, while the changes were suppressed by SSYX intake. The dogs in the pacing group had more episodes and longer durations of AF than that in the pacing ＋ SSYX group. SSYX markedly inhibited the increase in sympathetic nerves and upregulation of tumor necrosis factor-alpha and interleukin-6 expression in the pacing ＋ SSYX group. Furthermore, SSYX suppressed the decrease of acetylcholine and α7 nicotinic acetylcholine receptor protein induced by long-term intermittent atrial pacing. Conclusions： SSYX substantially prevents atrial electrical remodeling and the progression of AF. These effects of SSYX may have association with regulating the imbalance of autonomic nerve activity and the cholinergic anti-inflammatory pathway.