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一类随机变量序列加权和的Chover型重对数律

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数学学报（中文版） 2003年第5期46卷 999-1006页

作者：陈平炎柳向东暨南大学数学系广州510630 暨南大学统计系广州510630

对于具有某种尾渐近行为的独立同分布的随机变量序列,本文通过积分检验刻划了其加权部分和的极限结果,并作为推论获得了Chover型重对数律。把这些结果应用到经典的可和方式,获得了相应的结果。

关键词：重对数律积分检验加权部分和

细菌视紫红质激子的饱和密度及激子长度的研究

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中国激光 2001年第3期28卷 269-271页

作者：黄燕萍陈树德王祖赓李庆国国家教委华东师范大学量子光学开放实验室华东师范大学物理系上海200062 复旦大学生物物理系上海200433

对光能转换生物分子细菌视紫红质 (bR)作前向立体简并四波混频实验所测得的三阶非线性电极化率和它们的时间响应 ,用光循环结构模拟的三能级模型予以解释 ,并用位相空间充满理论模拟得到激子饱和密度和激子长度。

关键词：细菌视紫红质光敏生物分子激子饱和密度激子长度

Effects of vasoactive intestinal peptide on phenotypic and functional maturation of dendritic cells

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Effects of vasoactive intestinal peptide on phenotypic and f...

Trinuclear gold-catalyzed site-selective alkylation of peptides

第十次浙江省中西医结合肝病学术会议

作者： Jie Lu~a Ming-Hua Zheng~a Jie yan~b Yong-ping chen~(a,§) Jian-ping Pan~(b,§) ~aDepartment of lnfectious and Liver Diseases,First Affiliated Hospital,Wenzhou Medical College,Wenzhou 323000,P.R.China ~bDepartment of Microbiology and Parasitology,Zhejiang University School of Medicine,Hangzhou 310058,P.R.China

The present study was designed to investigate the effects of vasoactive intestinal peptide(VIP)on differentiation,maturation of dendritic cells(DCs)in *** were derived from the murine bone marrow hemopoietic progenito...

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang chengyihan Gu Yinghan chen Wencheng yan Yong Liang Weipeng Li chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Effects of vasoactive intestinal peptide on phenotypic and functional maturation of dendritic cells

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Effects of vasoactive intestinal peptide on phenotypic and f...

舌下含服粉尘螨滴剂治疗儿童过敏性哮喘和变应性鼻炎的临床评价

第十七次全国中西医结合肝病学术会议

作者： Jie Lu~a Ming-Hua Zheng~a Jie yan~b Yong-ping chen~(a,§), Jian-ping Pan~(b,§) a Department of Infectious and Liver Diseases, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 323000, P R. China b Department of Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou 310058, P R. China

The present study was designed to investigate the effects of vasoactive intestinal peptide (VIP) on differentiation, maturation of dendritic cells (DCs) in vitro. DCs were derived from the murine bone marrow hemopoietic progenitor cells by culturing in RPMI 1640 complete medium supplemented with GM-CSF and IL-4 in the presence or absence of various concentrations of vasoactive intestinal peptide (VIP) and lipopolysaccharide (LPS) The phenotype of DCs was analyzed by flow cytometry. Mixed leukocyte reaction (MLR) was employed to measure the capacity of DC to stimulate the allogeneic T cells. IL-12p70 secretion by DC was examined by ELISA. In the absence of LPS, VIP, in a dose dependent manner, up-regulated the expression of CDS0, CD86, CD54 and CD40, but down-regulated the expression of MHC class Ⅱ molecule (Ia). In the presence of LPS, VIP also dose dependently up-regulated the expression of CD80, CD86, CD54 and CD40, and down-regulated the expression of Ia. The capacity to stimulate alloreactive T cells and the production of IL-12p70 by DC were significantly augmented by VIP when compared with VIP-untreated DCs. These data suggest that VIP could promote the phenotypic and functional maturation of DCs, hereby regulating the type and outcome of the conducting immune response.

关键词： Dendritic cells Mixed leukocyte reaction IL-12 Costimulatory molecules Vasoactive intestinal peptide

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中华儿科杂志 2007年第10期45卷 736-741页

作者：曹兰芳陆权顾洪亮陈燕萍张源陆敏钱耀琴李岚许以平上海交通大学医学院附属仁济医院儿科 200001 上海交通大学附属儿童医院呼吸科上海交通大学医学院附属第九人民医院儿科上海中医药大学附属岳阳中西医结合医院浙江省中医院儿科上海交通大学医学院附属仁济医院过敏疾病防治中心 200001

目的评估舌下特异性免疫治疗药物"粉尘螨滴剂"治疗儿童过敏性哮喘及变应性鼻炎的疗效及安全性。方法采用随机双盲、安慰剂平行对照的研究方法,将278例年龄4～18岁粉尘螨过敏的哮喘和(或)鼻炎患儿随机分为治疗组(139例)和安慰剂组(139例)... 详细信息

目的评估舌下特异性免疫治疗药物"粉尘螨滴剂"治疗儿童过敏性哮喘及变应性鼻炎的疗效及安全性。方法采用随机双盲、安慰剂平行对照的研究方法,将278例年龄4～18岁粉尘螨过敏的哮喘和(或)鼻炎患儿随机分为治疗组(139例)和安慰剂组(139例),分别给予舌下含服"粉尘螨滴剂"或安慰剂,在治疗第2,3,4,6,10,14,18,22周进行随访,治疗第25周结束临床观察。对两组治疗前后的哮喘和鼻炎症状与体征评分、用药计分、肺功能及各项实验室指标、不良事件进行分析比较,并在试验结束前让患儿进行疾病转归的自我评价。结果 (1)278例研究对象中,共251例完成试验;(2)治疗组过敏性哮喘患者 PEF 日内变异率改变量-1.38,而安慰剂组仅为-0.90(P0.05);(6)用药25周以后,两组血清特异性 IgE(sIgE)水平较用药前无显著改变,而治疗组的血清特异性 IgG4平均水平显著增高(P<0.05);(7)试验期间未发生严重不良事件,与研究药物可能有关的不良反应主要表现为哮喘轻度发作和局部皮疹。结论"粉尘螨滴剂"是一种安全有效治疗儿童过敏性哮喘和变应性鼻炎的舌下特异性免疫治疗药物。

关键词：投药,舌下免疫疗法粉尘螨哮喘鼻炎,反应性,常年性

Clinical relationship between MDR1 gene and gallbladder cancer

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 296-299页

作者： Bai-Lin Wang, Hai-Ying Zhai, Bing-Yi chen, Shu-ping Zhai, Hai-yan yang, Xiao-ping chen, Wen-Tao Zhao and Lei Meng Guangzhou, China Third Department of Surgery, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China Depart- ment of Surgery, First People’s Hospital, Jining 272100, China Department of Surgery, General Hospital of PLA, Beijing 100853, China and Hepatic Surgery Center, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Third Department of Surgery First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 China. wbl672000@***

BACKGROUND: The most common mechanisms of mul- tidrug resistance (MDR) in cancer cells is the expression of an energy-dependent exfflux pump. P-glycoprotein (P-gp) encoded by MDR1 gene and multidrug associated protein (MRP) are well known proteins associated with MDR. In human cancers, the MDR1 gene expression is common in patients with intrinsic and acquired MDR. It is a major therapeutic problem in cancer chemotherapy. Previously we found that the MDR of HCC is related to MRP gene ex- pression and initiates the intrinsic MDR. The aim of this study is to study the expression of MDR1 gene encoding P-gp and MDR1 mRNA in primary gallbladder carcinoma, and analyze its clinical significance. METHODS: Immunohistochemistry (IHC) S-P method and in situ polymerase chain reaction (ISPCR) were used to detect the expression of P-gp and MDR1 mRNA in 53 cases of untreated primary gallbladder carcinoma and 12 ca- ses of cholecystitis (archival paraffin-embedded tissues). RESULTS: The positive expression rates of P-gp and MDR1 mRNA in the 53 cases and 12 cases were 60.38%, 71.69% and 25.00%, 33.33%, respectively. There was a significant difference between the two groups (P<0.05). The positive expression rate of P-gp and MDRlmRNA were 69.44%, 83.33% and 41.18%, 47.06% respectively in tissues in stage of Nevin against Nevin , (P<0.05). In well, moderately differentiated gallbladder carcinoma tissues, their expressions were 79.49%, 69.23% against 50.00%, 35.71% in low, undifferentiated tissues (P<0.05). CONCLUSIONS: MDR to gallbladder carcinoma is closely related to the intrinsic MDR and it provides an important evidence to reverse the MDR by detection of the MDR1gene. Meanwhile, MDR1 gene expression in gallbladder carcinoma is correlated with some biological characteris- tics , takes part in the carcinogenesis of gallbladder tissues, and acts as a valuable biomarker of prognosis.

关键词： gallbladder neoplasms gene drug resistance, multiple

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芦荟人参白酒的研制

食品科技 2004年第3期29卷 80-82页

作者：魏群赵军贾艳萍王英臣东北电力学院应用化学系吉林132012

芦荟富含多种营养成分和活性物质,具有很强的药理作用,是集医疗、保健、美容于一体的绿色植物。以芦荟为原料,辅以人参,经纯粮白酒浸泡而成的芦荟人参白酒,酒度38,酒体清亮透明,入口鲜美、醇和,具有很高的医疗、保健和美容价值。

关键词：芦荟人参浸泡芦荟人参白酒

基于固定化金属亲和整体柱的痕量微囊藻毒素富集分析

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分析测试学报 2025年第1期44卷 155-162,171页

作者：陈小燕杨玲苏立燊吴晓苹福州大学化学学院食品安全与生物分析教育部重点实验室福建福州350116 泉州市晋江环境监测站福建泉州362200 福建省妇幼保健院福建福州350001

基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体... 详细信息

基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体柱的萃取条件,在最优条件下,将poly(VIM-co-DVB)-Cu^(2+)整体柱用于毛细管微萃取(CME),并与高效液相色谱-质谱(HPLC-MS)检测技术联用,建立了环境水样品中3种MCs的高效富集分析方法。方法检出限为0.89~1.23 ng/L,加标回收率为80.0%~105%,相对标准偏差(RSD)不大于6.8%。该方法灵敏度高、准确性好,可为污染水体中微囊藻毒素的监测分析提供有效手段。

关键词：微囊藻毒素固定化金属亲和整体柱毛细管微萃取高效液相色谱-质谱