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Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

Current Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo yanG Le-hao REN Feng wang Pi-lin wang wen-yan wang Shu-ye LIN Department of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

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Adaptive modulation for SVD-based MIMO systems with outdated CSI

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The Journal of China Universities of Posts and Telecommunications 2009年第4期16卷 78-83页

作者： yan Zhi wang wen-bo wang Xiao-ting ZHENG Kan Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

The performance of singular value decomposition （SVD）-based multiple-input multiple-output （MIMO） with adaptive modulation （AM） is dependent on the accuracy of the channel state information （CSI） at the transmitter and the receiver. However, for a time-varying channel, the CSI obtained at the transmitter or the receiver is incorrect owing to an inherent delay or error. A typical system employing SVD suffers degradation in capacity when outdated CSI is used to transmit data. This article first addresses the adaptive modulation MIMO system designed under perfect CSI assumption. Based on that, two scenarios of outdated CSI are investigated and analyzed. The effect of imperfect CSI on the system performance is focused on and a simple post processing SNR （pSNR） adjustment design is proposed on AM system in the two scenarios for reducing degradation in average spectral efficiency （ASE）. Simulation results show that these designs provide good performance in an adaptive way, and enable the adaptive MIMO system considerably more to be robust against CSI imperfection.

关键词： MIMO SVD adaptive modulation ohtdated CSI

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Joint linear precoder and power allocation design for uplink MIMO systems with limited feedback

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 14-18页

作者： yan Zhi wang wen-bo wang Jian-feng ZHENG Kan Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

In this article, the authors consider joint design of a linear precoder and power allocation for uplink multiuser multiple input multiple output （MIMO） communication systems with limited feedback to improve the bit error rate （BER） performance for all users. Precoder selection from the codebook set is directly based on the exact BER performance, instead of other suboptimal criteria, to achieve the optimal precoder matrix, but closed-form expressions may not exist in the view of power allocation based directly on the BER criterion. From this perspective, the authors propose the joint transmitter optimization algorithm for the consideration of precoder design, with total power constraint for asymptotic MBER （AMBER） criterion. In this AMBER criterion, a closed-form solution has been derived for power allocation with an optimal precoder. The simulation results show that the proposed joint design algorithm can achieve a much better performance than precoding with uniform power allocation and only consideration of power allocation.

关键词： MIMO linear precoder power allocation spatial multiplexing multiuser

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Capacity of FH wireless multi-hop networks

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 78-83页

作者： WEI Dong-yan wang wen-bo PENG Mu-gen Key Laboratory of Universal Wireless Communication Ministry of Education Beij hag University of Posts and Telecommunications Beijing 100876 China

In this article,the capacity of wireless multi-hop networks with the frequency hopping（FH） technique is *** from the previous work based on non-spread spectrum（SS） system,this study is based on frequency hopping spread spectrum（FHSS） and the retransmission *** analysis results show that the normalized transport capacity decreases as 1/Mλ,when the total available frequency band is divided into M sub-bands for frequency hopping and the nodes are randomly distributed in space according to a Poisson point process with intensity λ .In this work,the best transmission range per hop to get the maximum capacity is also ***,the results summarize how the capacity of FH wireless multihop networks is affected by the outage probability,target signal to interference plus noise ratio（SINR） and other system parameters.

关键词： multihop frequency hopping capacity

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Toughening mechanism of lined Al_2O_3-ZrO_2 multiphaseceramics in SHS composite pipes

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Journal of University of Science and Technology Beijing 2006年第2期13卷 178-182页

作者： Guibo Yu wen yan Shuhai wang Baoxin Su Baolai Tan Mechanical Engineering College of Shijiazhuang Shijiazhuang 050003 China

Hypoeutectic and hypereutectic Al2O3-ZrO2 multiphase ceramics-lined composite pipes were produced by using the gravitational separation self-propagate high-temperature synthesis （SHS） process. The microstructure of the ceramics was observed by means of SEM and EPMA. The fracture toughness of the multiphase ceramics was tested by using the Vickers indentation method. The fracture toughness of hypoeutectic Al2O3-ZrO2 multiphase ceramics is 15.96 MPa·m^1/2 and that of hypoeutectic Al2O3-ZrO2 multiphase ceramics is 15.23 MPa·m^1/2. The toughening mechanisms were systematically investigated by means of SEM and XRD. The results show that the bridging toughening mechanism, stress induced ZrO2 transformation toughening mechanism, and microcrack toughening mechanism are the predominant toughening mechanism.

关键词： SHS multiphase ceramics eutectic structure toughening mechanism

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Increased interleukin-26 expression in proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1688-1692页

作者： Peng wang wen-yan wang Xue-Dong Zhang Department of Ophthalmology the First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology Chongqing Eye Institute

AIM: To detect the possible role of interleukin(IL)-26 in diabetic retinopathy(DR) ***: Subjects were divided into diabetes without retinopathy(DWR) group(n=20), non-proliferative diabetic retinopathy(NPDR) group(n=20), proliferative diabetic retinopathy(PDR) group(n=20) and normal control group(n=20). The protein expression of IL-26 in the serum and vitreous fluid were measured by enzyme-linked immunosorbent assay(ELISA). The m RNA change of IL-26 in peripheral blood mononuclear cells(PBMCs) was assessed by real-time polymerase chain ***: The serum expression of IL-26 in PDR group was significantly elevated compared with the normal control group, DWR group and NPDR group. The vitreous fluid concentration of IL-26 in PDR patients(without antiVEGF therapy) was also higher compared to normal controls. However, no obvious significance was found concerning the expression of IL-26 in vitreous fluid between PDR after anti-VEGF therapy and normal controls. In PDR group, the m RNA level of IL-26 significantly increased compared with the normal controls and DWR patients in the ***: Protein and m RNA expression of IL-26 are increased in serum, vitreous fluid and PBMCs in PDR patients, suggesting that IL-26 may be associated with the pathogenesis of PDR.

关键词： interleukin-26 serum vitreous fluid peripheral blood mononuclear cells proliferative diabetic retinopathy

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Postoperative Elevations of Neutrophil-to-lymphocyte and Platelet-to- lymphocyte Ratios Predict Postoperative Pulmonary Complications in Non-small Cell Lung Cancer Patients: A Retrospective Cohort Study

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Current Medical Science 2020年第2期40卷 339-347页

作者： yan wang Xu HUt Meng-chan SU yan wen wang Guo-wei CHEI Deparment of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China

The neutrophil-to-lymphocyte ratio(NLR)and the platelet-to-lymphocyte ratio(PLR)are found to increase in patients who develop postoperative complications(PCs).The aim of the present study was to explore the association of the perioperative changes of NLR(ANLR)and PLR(OPLR)with PCs in non-small cell lung cancer(NSCLC).Clinical data of 509 patients,who were diagnosed with NSCLC and underwent thoracoscopic radical resection between January 1,2014 and July 31,2016 at the Department of Thoracic Surgery,West China Hospital,were *** were divided into PC and non-PC groups,and clinical characteristics including ANLR and APLR were compared between *** optimal cut-off values of ONLR and APLR were determined by receiver operating characteristics(ROC)curves and patients were assigned to high ANLR/APLR and low ONLR/OPLR groups in terms of the cut-off *** characteristics and the incidence of different PCs were compared between the dichotomized *** and multivariate logistic regression analyses were performed to identify the independent risk factors for *** results showed that the ANLR and APLR in the PC group were significantly higher than those in the non-PC group(P6.6 or 0PLR>49 were more likely to experience postoperative pulmonary complications(PPCs)(P6.6(OR:2.453,95%CI:1.2244.914,P-0.011)and APLR>49(OR:2.231,95%CI:1.182-4.212,P-0.013)were predictive of *** conclusion,the ONLR and APLR may act as novel predictors for PPCs in NSCLC patients undergoing thoracoscopic radical lung resection,and patients with ONLR>6.6 or APLR>49 should be treated more actively to prevent or reduce PPCs.

关键词： neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio non-small cell lung cancer postoperative pulmonary complication

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Application of DC component to select fault branch in arc suppression coil grounding system

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Journal of Coal Science & Engineering(China) 2013年第3期19卷 396-401页

作者： Zhi-Jie wang yan-wen wang School of Mechanical Electrical and Information Engineering China University of Mining and Technology (Beijing) Beijing 100083 China

When single phase earth fault occurs in the arc suppression coil grounding system, the amplitude of the transient capacitance current is high and decays fast, but the attenuation of the transient inductance current is much slower. This paper analyses the DC component of fault branch, and has found it is much bigger than that of the normal branches in transient state. All the simulation results obtained from three compensation types, different fault time and different wave cycles show that the DC component of fault branch is much higher than that of those normal branches. These results verify the effectiveness of taking the DC component as the method of fault line selection in the arc suppression coil grounding system.

关键词： DC component arc suppression coil fault line selection transient state

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Charge transporting materials for perovskite solar cells

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Rare Metals 2021年第10期40卷 2690-2711页

作者： Ting Ji Ying-Kui wang Lin Feng Guo-Hui Li wen-yan wang Zhan-Feng Li Yu-Ying Hao yan-Xia Cui College of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi ProvinceTaiyuan University of TechnologyTaiyuan 030024China

Perovskite solar cells(PSCs) have made great progress since 2009 and become the focus of current research. As an important part of PSCs, charge transporting materials play an important role in the performance of the devices. In this review, we introduce the evolution of electron and hole transporting materials in PSCs in recent years and summarize some typical charge transporting materials and their applications in PSCs. For electron transporting materials, metal oxides(TiO_(2), SnO_(2) and ZnO) and organic materials(fullerenes, non-fullerenes and their derivatives)are the most widely used materials in PSCs. For hole transporting materials, small molecule spiro-OMeTAD(2,2’,7,7’-Tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9’-spirobifluorene), polymer PEDOT:PSS(poly(3,4-ethylenedioxythiophene): polystyrene sulfonate), PTAA(poly-[bi(4-phenyl)](2,4,3-trimethylphenyla-mine)), P3 HT(poly(3-hexythiophene)) and inorganic materials(NiOx, CuSCN, CuO) are adopted in PSCs. Finally, different types of charge transporting materials are summarized and their future development is prospected.

关键词： Perovskite Solar cells Electron transporting materials Hole transporting materials

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Regulation of a vacuolar proton-pumping P-ATPase MdPH5 by MdMYB73 and its role in malate accumulation and vacuolar acidification

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aBIOTECH 2023年第4期4卷 303-314页

作者： Xiao-Yu Huang Ying Xiang Yu-wen Zhao Chu-Kun wang Jia-Hui wang wen-yan wang Xiao-Long Liu Quan Sun Da-Gang Hu National Research Center for Apple Engineering and Technology Shandong Collaborative Innovation Center of Fruit and Vegetable Quality and Efficient ProductionCollege of Horticulture Science and EngineeringShandong Agricultural UniversityTai’an 271018ShandongChina

As the main organic acid in fruits,malate is produced in the cytoplasm and is then transported into the *** accumulates by vacuolar proton pumps,transporters,and channels,affecting the taste and flavor of *** the three types of proton pumps(V-ATPases,V-PPases,and P-ATPases),the P-ATPases play an important role in the transport of malate into *** this study,the transcriptome data,collected at different stages after blooming and during storage,were analyzed and the results demonstrated that the expression of MdPH5,a vacuolar proton-pumping P-ATPase,was associated with both pre-and post-harvest malate ***,MdPH5 is localized at the tonoplast and regulates malate accumulation and vacuolar *** addition,MdMYB73,an upstream MYB transcription factor of MdPH5,directly binds to its promoter,thereby transcriptionally activating its expression and enhancing its *** this way,MdMYB73 can also affect malate accumulation and vacuolar ***,this study clarifies how MdMYB73 and MdPH5 act to regulate vacuolar malate transport systems,thereby affecting malate accumulation and vacuolar pH.

关键词： Apple Malate accumulation P-ATPase MdPH5 MdMYB73

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