Postoperative Elevations of Neutrophil-to-lymphocyte and Platelet-to- lymphocyte Ratios Predict Postoperative Pulmonary Complications in Non-small Cell Lung Cancer Patients: A Retrospective Cohort Study

作     者：Yan WANG Xu HUt Meng-chan SU Yan wen WANG Guo-wei CHEI 

作者机构：Deparment of Thoracic SurgeryWest China HospitalSichuan UniversityChengdu 610041China West China School of MedicineSichuan UniversityChengdu 610041China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2020年第40卷第2期

页      面：339-347页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio non-small cell lung cancer postoperative pulmonary complication 

摘      要：The neutrophil-to-lymphocyte ratio(NLR)and the platelet-to-lymphocyte ratio(PLR)are found to increase in patients who develop postoperative complications(PCs).The aim of the present study was to explore the association of the perioperative changes of NLR(ANLR)and PLR(OPLR)with PCs in non-small cell lung cancer(NSCLC).Clinical data of 509 patients,who were diagnosed with NSCLC and underwent thoracoscopic radical resection between January 1,2014 and July 31,2016 at the Department of Thoracic Surgery,West China Hospital,were *** were divided into PC and non-PC groups,and clinical characteristics including ANLR and APLR were compared between *** optimal cut-off values of ONLR and APLR were determined by receiver operating characteristics(ROC)curves and patients were assigned to high ANLR/APLR and low ONLR/OPLR groups in terms of the cut-off *** characteristics and the incidence of different PCs were compared between the dichotomized *** and multivariate logistic regression analyses were performed to identify the independent risk factors for *** results showed that the ANLR and APLR in the PC group were significantly higher than those in the non-PC group(P6.6 or 0PLR49 were more likely to experience postoperative pulmonary complications(PPCs)(P6.6(OR:2.453,95%CI:1.2244.914,P-0.011)and APLR49(OR:2.231,95%CI:1.182-4.212,P-0.013)were predictive of *** conclusion,the ONLR and APLR may act as novel predictors for PPCs in NSCLC patients undergoing thoracoscopic radical lung resection,and patients with ONLR6.6 or APLR49 should be treated more actively to prevent or reduce PPCs.