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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

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Neural Regeneration Research 2025年第1期20卷 184-185页

作者： Teruyuki Ishikura Tatsusada okuno Department of Molecular Neuroscience Graduate School of MedicineOsaka UniversityOsakaJapan Department of Neurology Osaka University Graduate School of MedicineOsaka UniversityOsakaJapan

In this article, we present our previous research, which highlighted adenosine triphosphate(ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD). In NMOSD pathology, damageassociated molecular patterns(DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD.

关键词： pain acute pathology

Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology

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Neural Regeneration Research 2025年第9期20卷 2589-2590页

作者： Mikio Shimizu Tatsusada okuno Department of Neurology Osaka University Graduate School of MedicineSuitaJapan Department of Neurology Osaka General Medical CenterOsakaJapan

Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal *** with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).

关键词： paralysis sclerosis

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Numerical analysis of surface plasmons excited on a thin metal grating

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第1期7卷 55-70页

作者： okuno yoichi SUyAMA Taikei Graduate School of Science and Technology Kumamoto University Kumamoto 860-8555 Japan Department of Electrical and Computer Engineering Kumamoto University Kumamoto 860-8555 Japan

The authors numerically investigated the characteristics of surface plasmons excited on a thin metal grating placed in planer or conical mounting. After formulating the problem, the solution method, yasuura＇s method （a modal expansion approach with least-squares boundary matching） was described. Although the grating is periodic in one direction, coupling between TE and TM waves Occurs because arbitrary incidence is assumed. This requires the employment of both TE and TM vector modal functions in the analysis. Numerical computations showed：（l） the excitation of surface plasmons with total or partial absorption of incident light; （2） the resonance character of the coefficient of an evanescent order that couples the plasmon surface wave; （3） the field profile and Poynting＇s vector. The plasmons excited on the surfaces of a thin metal grating are classified into three types： SISP, SRSP, and LRSP, different from each other in the feature of field profile and energy flow. In addition, the eigenvalue of a plasmon mode was obtained by solving a sequence of diffraction problems with complex-valued angles of incidence and using the quasi-Newton algorithm to predict the real angle of incidence at which the absorption occurs.

关键词： Thin metal grating Plasmon modes Resonance absorption Numerical analysis

Functional imaging of astrocyte activity

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Neural Regeneration Research 2021年第6期16卷 1206-1207页

作者： Hiroki Kato Tatsusada okuno Department of Nuclear Medicine and Tracer Kinetics Osaka University Graduate School of Medicine2-2 Yamadaoka SuitaOsakaJapan Department of Neurology Osaka University Graduate School of Medicine2-2 Yamadaoka SuitaOsakaJapan

Astrocytes have become known to play a central role in various neuroinflammatory *** evaluation of astrocyte activity using functional imaging is becoming more *** metabolism or oxygen metabolism in the brain can be assessed using the established clinical imaging methods of F-18 fluorodeoxyglucose positron emission tomography(PET)and O-15 PET,***,until recently,the highly specific evaluation of metabolic activity in astrocytes has never been applied *** acetate is selectively taken up and metabolized by astrocytes,its usefulness as a tracer for measuring astrocyte activity has been proposed in basic research.

关键词： metabolism assessed clinical

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Last deglacial relative sea level variations in Antarctica derived from glacial isostatic adjustment modelling

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Geoscience Frontiers 2013年第6期4卷 623-632页

作者： Jun’ichi okuno Hideki Miura National Institute of Polar Research 10-3 Midori-choTachikawaTokyo 190-8518Japan Research Institute for Global Change Japan Agency for Marine-Earth Science and Technology3173-25 Showa-machiKanazawa-kuYokohama 236-0001Japan

We present relative sea level （RSL） curves in Antarctica derived from glacial isostatic adjustment （GIA）predictions based on the melting scenarios of the Antarctic ice sheet since the Last Glacial Maximum （LGM）given in previous ***,Holocene-age RSL observations obtained at the raised beaches along the coast of Antarctica are shown to be in agreement with the GIA *** differences from previously published ice-loading models regarding the spatial distribution and total mass change of the melted ice are *** models were also derived from GIA modelling; the variations can be attributed to the lack of geological and geographical evidence regarding the history of crustal movement due to ice sheet ***,we summarise the previously published ice load models and demonstrate the RSL curves based on combinations of different ice and earth *** RSL curves calculated by GIA models indicate that the model dependence of both the ice and earth models is significantly large at several sites where RSL observations were *** particular,GIA predictions based on the thin lithospheric thickness show the spatial distributions that are dependent on the melted ice thickness at each *** characteristics result from the short-wavelength deformation of the ***,our predictions strongly suggest that it is possible to find the average ice model despite the use of the different models of lithospheric *** sea level and crustal movement observations,we can deduce the geometry of the post-LGM ice sheets in detail and remove the GIA contribution from the crustal deformation and gravity change observed by space geodetic techniques,such as GPS and GRACE,for the estimation of the Antarctic ice mass change associated with recent global warming.

关键词： Antarctic ice sheet Relative sea level Glacial isostatic adjustment Melting history Lithospheric thickness

Homogeneity tests on neutron shield concrete

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Nuclear Science and Techniques 2014年第A1期25卷 57-61页

作者： Koichi okuno Hiroshi Iikura HAZAMA ANDO Technical Research Institute 515-1 Karima Tsukuba Ibaraki 305-0822 Japan JAEA Quantum Beam Science Directorate 2-4 Shirakata Tokai-mura Naka-gun Ibaraki 319-1195 Japan

In recent years, neutrons have been studied for application in fields such as material analysis and boron neutron capture therapy. To create a compact shield for these facilities, a neutron shield concrete is developed. Verifying the homogeneity of the concrete is important to ensure adequate shielding performance. In this research, neutron radiography images of the concrete are taken using the Thermal Neutron Radiography Facility (TNRF) of the JRR-3 research reactor, and the transmission ratio of the thermal neutrons were estimated. The results showed that the transmission ratio of the concrete was almost the same at each depth. © 2014, Science Press. All rights reserved.

关键词：中子屏蔽同质性测试研究反应堆中子俘获屏蔽性能照相设备中子照相

Modified Classical Over Barrier Model for Multi-Charged Ion in Collisions with Multiple Electron Target at Energies Below 1 keV/u

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Plasma Science and Technology 2010年第3期12卷 369-371页

作者： K.ISHII K.okuno Department of Physics Nara Women's University Kitauoyanishi

Charge transfer cross sections for Kr^q＋ with Ne are calculated quantitatively by using modified classical over barrier model in order to clarify energy dependence of charge transfer cross sections in low energy region. Essential of this model is taking the induced dipole potential into consideration. As a result, this calculation can reproduce systematic energy dependence of experimental results. This suggests that the bending trajectory of the projectile due to an induced dipole potential should be considered to describe pictures of collisions at low energy regime below 1 keV/u.

关键词： atomic processes highly charged ion charge transfer classical over barrier