Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology

作     者：Mikio Shimizu Tatsusada Okuno Mikio Shimizu;Tatsusada Okuno

作者机构：Department of NeurologyOsaka University Graduate School of MedicineSuitaJapan Department of NeurologyOsaka General Medical CenterOsakaJapan 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第9期

页      面：2589-2590页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported in port by the JSPS KAKENHI(grant number 22K07539 to MS) funded by Mitsubishi Tanabe Pharma Corporation 

主　　题：paralysis sclerosis 

摘      要：Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal *** with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).