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Isospecific Polymerization of Methyl Methacrylate by Intramolecular Rare-Earth Metal Based Lewis Pairs

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Chinese Journal of Chemistry 2021年第1期39卷 149-156页

作者： yiqun Zhou Shengjie Jiang xin Xu Key Loborotory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China

A series of cationic rare-earth aryloxide complexes,ie,,[LREOAr^(1)]^(+)[B(C_(6)F_(5))_(4)]^(-)(L=CH_(3)C(NAr)CHC(CH_(3))(NCH(R)CH_(2)PPh_(2));RE=y,Lu;Ar'=2,6-tBU_(2)-C_(6)H_(3),2,6-(PhCMe_(2))_(2)-4-Me-C_(6)H_(2);Ar=2,6-iPr_(2)-C_(6)H_(3),2,6-(Ph_(2)CH)_(2)-4-iPr-C_(6)H_(2);R=H,CH_(3),iPr,Ph),were prepared and ap-plied to the Lewis pair polymerization of methyl methacrylate(MMA).The stereoregularity of the resulting PMMA was significantly affected by the R substituent on the pendant arm of the tridentate NNP ligand,and was found to increase with increase in the steric hindrance of R.

关键词： Rare-earth Lewis pair Tridentate ligand Polymerization Tacticity

Anick Resolution and the Minimal Projective Resolution of U_(q)+(C_(3))

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Acta Mathematica Sinica,English Series 2023年第6期39卷 1022-1052页

作者： Ling Ling MAO Xiao Long xin School of Mathematics Northwest UniversityXi'an 710127P.R.China School of Science Xi'an Polytechnic UniversityXi'an 710048P.R.China

In this paper,from the Anick’s resolution and Grobner-Shirshov basis for quantized enveloping algebra of type C_(3),we compute the minimal projective resolution of the trivial module U_(q)+(C_(3))and as an applicatio... 详细信息

关键词： Anick resolution minimal projective resolution Grobner-Shirshov basis global dimension

Neddylation Regulation of Immune Responses

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Research 2024年第3期2023卷 545-559页

作者： Hongmei Mao xin Lin yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences HangzhouZhejiang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

Preparation and photo-catalytic activity of TiO_2-coated medical stone-based porous ceramics

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International Journal of Minerals,Metallurgy and Materials 2013年第6期20卷 593-597页

作者： Ru-qin Gao xin-mei Hou School of Environmental and Municipal Engineering North China University of Water Resources and Electric Power School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Medical stone-based porous ceramics as a carrier were prepared by ultra-fine grinding and low-temperature sintering method. Nano-TiO~ thin films were loaded on the carrier by chemical liquid deposition method using titanium tetrachloride as a precursor. The micro-morphology and microstructure of the synthesized samples were characterized using X-ray diffraction, scanning electron microscopy with energy dispersive spectrometry, and mercury injection method. The photo-catalytic activity of the TiO2 thin films was investigated by degrading formaldehyde. The main crystalline phase in the TiO2 thin films calcined at 550~C is anatase with the average particle size about 10 nm. The specific surface area of the carrier-coated nano-TiO2 increases from 3.68 to 5.32 m2/g. The formaldehyde removal rate of the TiO2/medical stone-based porous ceramics irradiated under an ultraviolet lamp for 120 min reaches 85.6%.

关键词： porous materials ceramics medical stone titanium dioxide thin films formaldehyde photocatalysis

Relationship between ecological stoichiometry and plant community diversity in the upper reaches of Tarim River,northwestern China

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Journal of Arid Land 2020年第2期12卷 227-238页

作者： ZHAO Jingjing GONG Lu CHEN xin College of Resources and Environment Science Xinjiang UniversityUrumqi 830046China Key Laboratory of Oasis Ecology Xinjiang UniversityUrumqi 830046China

Changes in ecological stoichiometry reflect nitrogen(N),phosphorus(P)and both N and P limitations in a plant community,which in turn affect plant diversity of the ***,the relationship between plant community diversity and ecological stoichiometry has not yet been fully researched in arid and semi-arid *** stoichiometry and plant community diversity indices of eighteen communities in the upper reaches of Tarim River,northwestern China,were analyzed by multivariate analysis of variance in *** correlation between ecological stoichiometry and plant community diversity was assessed by redundancy analysis(RDA).Results indicated that the Margalef index was significantly correlated with carbon(C)and P concentrations,the Simpson index and Shannon-Weaner index were significantly correlated with plant C concentration,and the Pielou index was significantly correlated with plant C and N ***,C:N and C:P ratios had significant impacts on plant community *** results highlight the importance of ecological stoichiometry in driving plant community diversity in the upper reaches of Tarim River,northwestern China.

关键词： Margalef index Simpson index Shannon-Weaner index redundancy analysis Tarim River

Fully Chemical Recyclable Poly(γ-butyrolactone)-based Copolymers with Tunable Structures and Properties

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Chinese Journal of Polymer Science 2022年第5期40卷 456-461页

作者： yi-Huan Liu xin yuan Jia-Qi Wu Ming-Xuan Luo xin Hu Ning Zhu Kai Guo Collegeof Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjing 211800China Collegeof Materials Science and Engineering Nanjing Tech UniversityNanjing 211800China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 211800China

The emerging chemical recyclable polymers,such as poly(γ-butyrolactone)(PGBL)and poly((R)-3,4-trans six-membered ring-fused GBL)(P((R)-M)),provide a good solution to the plastic ***,these homopolymers suffer from limited structures and ***,we reported a fully chemical recyclable copolymer P(GBL-co-((R)-M))through ring-opening copolymerization(ROCOP)of GBL and(R)-*** employing organomagnesium as the catalyst and regulating the reaction conditions,the chemical structures of copolymers were wellcontrolled(GBL content=13%-78%,Mn=6560-15600 g/mol,DM=1.08-1.59).The resultant P(GBL-co-((R)-M))exhibited fully chemical recyclability,which rapidly and quantitatively depolymerized into initial GBL and(R)-M monomer through *** varying GBL content,tunable thermal properties were achieved for P(GBL-co-((R)-M)).The onset decomposition temperatures of copolymers varied from 193°C to 234°C.A linear evolution of glass transition temperature(T_(g))of P(GBL-co-((R)-M))versus GBL content was obtained as following equation of Tg=-1.06×GBL mol%×100+*** hope that the reported fully chemical recyclable copolymers with tunable structures and properties would serve as the candidate material for sustainable applications.

关键词： Poly(γ-butyrolactone)-based copolymers Ring-opening copolymerization Chemical recyclability Organomagnesium

18β-Glycyrrhetinic Acid Improves Cardiac Diastolic Function by Attenuating Intracellular Calcium Overload

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Current Medical Science 2020年第4期40卷 654-661页

作者： Jun HAN Guan-hua SU yu-hui WANG yong-xin LU Hong-liang ZHAO xin-xin SHUAI Department of Cardiology Wuhan Fourth HospitalPuai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430033China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Summary:Ranolazine,a late sodium current inhibitor,has been demonstrated to be effective on heart failure.18B-glycyrrhetinic acid(18β-GA)has the similar inhibitory effect on late sodium ***,its effect on diastolic function is still *** study aimed to determine whether 18β-GA can improve the diastolic function and to explore the underlying *** male Sprague Dawley(SD)rats of Langendorff model were randomly divided into the following groups:group A,normal cardiac perfusion group;group B,ischemia-reperfusion group;group C,ischemia-reperfusion with anemoniasulcata toxinⅡ(ATX-Ⅱ);group D,ranolazine group;and group E,18β-GA group with four different ***,a pressure-overloaded rat model induced by trans-aortic constriction(TAC)was *** and hemodynamics were used to evaluate diastolic function at 14th day after *** of free intracellular calcium(Ca27)concentration was indirectly detected by laser scanning confocal microscope to confirm the inhibition of late sodium *** the intervention of ATX-Ⅱon ischemia reperfusion injury group,5 umol/L ranolazine,and 5,10,20,40μmol/L 18β-GA could improve ATX-I-induced cardiac diastolic dysfunction.630 mg/kg glycyrrhizin tablets could improve cardiac diastolic function in the pressure-overloaded rats.18B-GA and ranolazine had similar effects on reducing the free calcium in *** study demonstrates that 18B-GA and glycyrrhizin could improve diastolic dysfunction induced by ischemia-reperfusion injury in Langendorff-perfused rat hearts and pressure-overloaded *** mechanism may be attributed to the inhibition of enhanced late sodium currents.

关键词： glycyrrhetinic acid diastolic function calcium overload

Petrogenesis and geochemistry of the host monzogranite and mafic enclaves from the Triassic Wulong pluton in South Qinling, central China

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Chinese Journal Of Geochemistry 2009年第4期28卷 432-439页

作者： WANG Juan LI xin China University of Petroleum Shandong Dongying 257061 China Geological Research Institute of Shengli Oilfield Company Limited SINOPEC Shandong Dongying 257015 China Geophysical Research Institute of Shengli Oilfield Company Limited SINOPEC Shandong Dongying 257022 China

The Wulong pluton was emplaced in the metamorphic complex of the Mesoproterozoic Foping Group, South Qinling. A few mafic enclaves which are rounded in shape with sharp boundaries with the host granites in the southern part of the pluton. Based on petrography, geochemistry and chronology data, it is indicated that the Wulong pluton shows some adakitic affinities with depletion in HREE (yb=0.33–0.96 μg/g, y=4.77–11.2 μg/g); enrichment in Sr (643–1115 μg/g) and Ba (775–1386 μg/g), high Sr/y ratios (57.3–160) and y/yb ratios (11.0–14.3), and slightly negative Eu anomaly (δEu=0.70–0.83). These patterns suggest a feldspar-poor and garnet±amohibole-rich fractionation mineral assemblage. The mafic enclaves have high concentrations of Mg (MgO=4.15%–8.13%), Cr (14.8–371 μg/g), and Ni (20.0–224 μg/g), and high Nb/Ta ratios (15.42–21.9). It seems that the underplating mantle magma was responsible for the generation of the mafic magma. Companied with the results of investigations for the Qinling Orogenic Belt, it was found that partial melting of the thickened lower crust, which was triggered by the underplated mantle-derived magmas, had generated the felsic magma. The Wulong pluton provided evidence for a mixing and mingling process of two kinds of mamma. Its formation probably represents the oceanic slab breakoff during the late orogenic stage in the Qinling area.

关键词：二长花岗岩地球化学镁铁质南秦岭岩体飞地三叠纪成因

Regulation of TAZ in cancer

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Protein & Cell 2016年第8期7卷 548-561页

作者： xin Zhou Qun-ying Lei Key Laboratory of Metabolism and Molecular Medicine Ministry of Education and Department of Biochemistry and Molecular Biology and Institutes of Biomedical Sciences Fudan University Shanghai Medical College Shanghai 200032 China Department of Cancer Biology University of Texas MD Anderson Cancer Center Houston TX 77030 USA

TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene （WW domain containing transcription regulator 1）. TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled recep- tors （GPCRs）, cellular energy status, hypoxia and osmo- tic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition （EMT）, and stemness in multiple human cancers. We discuss here the regulators and regulation of TAT. We also highlight the tumorigenic roles of TAZ. and its potential therapeutic impact in human cancers.

关键词： TAZ the Hippo pathway cancer