Neddylation Regulation of Immune Responses

作     者：Hongmei Mao Xin Lin Yi Sun Hongmei Mao;Xin Lin;Yi Sun

作者机构：Cancer Institute(Key Laboratory of Cancer Prevention and InterventionChina National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for ImmunologySchool of MedicineTsinghua UniversityBeijing 100084China Changping LaboratoryBeijing 102206China Cancer Center of Zhejiang UniversityHangzhou 310029China Zhejiang Provincial Clinical Research Center for CancerHangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical SciencesHangzhouZhejiang ProvinceChina Research Center for Life Science and Human HealthBinjiang Institute of Zhejiang UniversityHangzhou 310053China. 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2024年第2023卷第3期

页      面：545-559页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：the funds from National Natural Science Foundation of China(92253203 and U22A20317)to Y.S the Zhejiang Provincial Natural Science Foundation of China(LD22H300003)to Y.S the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002)to Y.S a grant from Research Center for Life Science and Human Health,Binjiang Institute of Zhejiang University(ZY202205SMKY007)to Y.S 

主　　题：activation thereby initiating 

摘      要：Neddylation plays a vital role in post-translational modification, intricately shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. Specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.