检索结果-南通市图书馆

Twisted fiber microfluidics:a cutting-edge approach to 3D spiral devices

Microsystems & Nanoengineering 2024年第1期10卷 193-202页

作者： Shunsuke Kato Daniel W.Carlson Amy Q.Shen Yuanyuan Guo Department of Electrical Information and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Micro/Bio/Nanofluidics Unit Okinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Graduate School of Biomedical Engineering Tohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Department of Physiology Graduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan

The development of 3D spiral microfluidics has opened new avenues for leveraging inertial focusing to analyze small fluid volumes,thereby advancing research across chemical,physical,and biological disciplines.While traditional straight microchannels rely solely on inertial lift forces,the novel spiral geometry generates Dean drag forces,eliminating the necessity for external fields in fluid manipulation.Nevertheless,fabricating 3D spiral microfluidics remains a labor-intensive and costly endeavor,hindering its widespread adoption.Moreover,conventional lithographic methods primarily yield 2D planar devices,thereby limiting the selection of materials and geometrical configurations.To address these challenges,this work introduces a streamlined fabrication method for 3D spiral microfluidic devices,employing rotational force within a miniaturized thermal drawing process,termed as mini-rTDP.This innovation allows for rapid prototyping of twisted fiber-based microfluidics featuring versatility in material selection and heightened geometric intricacy.To validate the performance of these devices,we combined computational modeling with microtomographic particle image velocimetry(uTPiM)to comprehensively characterize the 3D flow dynamics.Our results corroborate the presence of a steady secondary flow,underscoring the effectiveness of our approach.Our 3D spiral microfluidics platform paves the way for exploring intricate microflow dynamics,with promising applications in areas such as drug delivery,diagnostics,and lab-on-a-chip systems.

关键词： thereby straight twisted

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Stem Cell Competition

引用

Neuroscience Bulletin 2024年第2期40卷 277-279页

作者： Yanan Li Jie He State Key Laboratory of Neuroscience Institute of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Cell competition is an adaptive surveillance mechanism to ensure the robustness of developmental outputs,maintain tissue integrity,and regulate tumor progression in multicellular organisms,which is highly conserved from invertebrates to vertebrates[1].At the cellular level,cell competition represents a non-cell-autonomous process in that cells can sense the fitness of their neighbors through cellular interactions,thereby eliminating low-fitness cells and expanding high-fitness counterparts,however,cells develop normally in homogenous populations.

关键词： thereby maintain eliminating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exercise immunology:Novel insights

引用

Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： David C.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(COVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune system.Questions were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent COVID-19 or mitigate symptoms when ill.Could MVPA bolster immunity among those most prone to COVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the COVID-19 cytokine storm?

关键词： immunity inflammation thereby

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Astrocyte-derived ATP:A New Etiological Factor for Autism Spectrum Disorder

引用

Neuroscience Bulletin 2022年第1期38卷 104-106页

作者： Jie Li Patrizia Rubini Yong Tang Peter Illes School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu610075China International Collaborative Centre on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengdu610075China Rudolf Boehm Institute for Pharmacology and Toxicology University of Leipzig04109LeipzigGermany

In the central nervous system,purinergic signaling plays an important role in maintaining the functions of neurons,astrocytes,and microglia,thereby regulating brain homeostasis,with consequences for higher-order cognitive processes[1].ATP released from astrocytes in conjunction with several additional signaling molecules modulates neuronal circuits.

关键词： thereby consequences purine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exposure to Chlorinated Paraffins in the Sixth Total Diet Study-China,2016‒2019

引用

China CDC weekly 2022年第9期4卷 172-175页

作者： Yang Liu Shuang Wang Lirong Gao Lili Cui Jingguang Li Bing Lyu Lei Zhang Minghui Zheng Yongning Wu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijingChina University of the Chinese Academy of Sciences BeijingChina Institute of Environment and Ecology Shandong Normal UniversityJi’nan CityShandong ProvinceChina NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina

Summary What is already known about this topic?Short-chain chlorinated paraffins(SCCPs)are persistent organic pollutants that are toxic to organisms.Medium-chain chlorinated paraffins(MCCPs)have similar properties.Chlorinated paraffins(CPs)may be biomagnified through the food chain,thereby threatening human health.What is added by this report?The concentrations of SCCP and MCCP in each food sample were 5-265 and 4-306 ng/g,respectively.The estimated dietary exposure to CPs was relatively lower than the threshold set in the current guidelines.What are the implications for public health practice?The production and use of SCCP and MCCP have not been prohibited in China yet.Further studies are needed to assess the health risks through dietary exposure to CPs.

关键词： properties. thereby Total

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of Blockchain in Trusted Digital Vaccination Certificates

引用

China CDC weekly 2022年第6期4卷 106-110页

作者： Zixiong Zhao Jiaqi Ma Chinese Centre for Disease Control and Prevention BeijingChina

With the increasing number of coronavirus disease 2019(COVID-19)cases and worldwide vaccination coverage,‘vaccination passports’(vaccination certificates)may become a required permit for global travel,thereby supporting economic recovery.On March 7,2021,Wang Yi,State Councilor and Foreign Minister of China,announced the launch of the Chinese version of an‘international travel health certificate’at a press conference of the National People’s Congress and the Chinese Political Consultative Conference.He proposed a feasible‘Chinese solution’for promoting the recovery of the global economy and the facilitation of cross-border travel,and hoped that the international travel health certificate and vaccination passport can be mutually authenticated.

关键词： travel thereby mutually

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complex-frequency waves:beat loss and win sensitivity

引用

Light(Science & Applications) 2024年第2期13卷 181-183页

作者： Qingqing Cheng Tao L School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Respiratory Diseases and Critical Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized complex-frequency waves can impart a virtual gain to molecule sensing systems,which can effectively restore information lost due to intrinsic molecular damping.The enhancement notably amplifies the signal of trace molecular vibrational fingerprints,thereby substantially improving the upper limit of sensitivity.

关键词： thereby Complex limit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fc receptor-like 5(FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma

引用

Signal Transduction and Targeted Therapy 2024年第2期9卷 724-737页

作者： Zhengyu Yu Hexian Li Qizhong Lu Zongliang Zhang Aiping Tong Ting Niu Department of Hematology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Multiple myeloma(MM)remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell(CAR-T)therapy.Current targets of CAR-T cells used in MM immunotherapy have limitations,with a subset of patients experiencing antigen loss resulting in relapse.Therefore,novel targets for enhancing CAR-T cell therapy in MM remain needed.Fc receptor-like 5(FCRL5)is a protein marker with considerably upregulated expression in MM and has emerged as a promising target for CAR-T cell therapeutic interventions,offering an alternative treatment for MM.To further explore this option,we designed FCRL5-directed CAR-T cells and assessed their cytotoxicity in vitro using a co-culture system and in vivo using MM cell-derived xenograft models,specifically focusing on MM with gain of chromosome 1q21.Given the challenges in CAR-T therapies arising from limited T cell persistence,our approach incorporates interleukin-15(IL-15),which enhances the functionality of central memory T(TCM)cells,into the design of FCRL5-directed CAR-T cells,to improve cytotoxicity and reduce T-cell dysfunction,thereby promoting greater CAR-T cell survival and efficacy.Both in vitro and xenograft models displayed that FCRL5 CAR-T cells incorporating IL-15 exhibited potent antitumor efficacy,effectively inhibiting the proliferation of MM cells and leading to remarkable tumor suppression.Our results highlight the capacity of FCRL5-specific CAR-T cells with the integration of IL-15 to improve the therapeutic potency,suggesting a potential novel immunotherapeutic strategy for MM treatment.

关键词： directed thereby offering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of the induced radioactivity in the treatment room of the heavy-ion medical machine in Wuwei using PHITS

引用

Nuclear Science and Techniques 2023年第2期34卷 153-166页

作者： Ying Luo Sheng‑Cong Huang Hui Zhang Hai‑Jun Mao Qiang Li Zhong‑Ying Dai Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Science Lanzhou 730000China Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine Lanzhou 730000China Lanzhou University Lanzhou 730000China

Carbon-ion radiotherapy(CIRT)offers unique physical and biological advantages over photon radiotherapy.However,some materials and devices in the CIRT treatment room become radioactive under bombardment by therapeutic carbon-ion beams due to nuclear reactions,thereby leading to possible radiation hazards to medical staff and additional and unwanted doses to patients.This study assessed the level of induced radioactivity in the treatment room of the Heavy-Ion Medical Machine(HIMM)in Wuwei.Monte Carlo simulations using PHITS were performed for a conservative case under the conditions of maximum beam energy and intensity provided by the HIMM facility.The geometry and configuration of Treatment Room 2 of the HIMM facility in Wuwei were adopted.We evaluated the activation of air,the phantom,and the components of the beamline,such as the primary collimator(PC),ridge filter(RF),and multileaf collimator(MLC).For air activation,we calculated the medical staff immersion external exposure and inhalation internal exposure caused by the corresponding radionuclides.For phantom activation,we estimated the additional dose to the patient’s family members owing to secondary photons after treatment.In addition,the exemption or non-exemption of the component material activation was assessed.The results showed that external radiation caused by air activation was the main source of the annual effective dose at approximately 0.5 mSv/y.The induced radioactivity exposure to family members of a patient after CIRT was approximately 40μSv,sufficiently lower than the public dose limit of 1 mSv/a.The induced radioactivity of the PC,RF,and MLC was all above the exempt levels after the devices were retired,whereas the induced radioactivity of the RS and compensator could reach the exempt levels after one patient session.Our study indicated that medical staff engaged in CIRT should stay away from the high-dose-rate area of induced radioactivity along the beam direction,shorten the residence time in the treatment room as much as possible,and store

关键词： activation approximate thereby

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors

引用

Neural Regeneration Research 2022年第10期17卷 2194-2196页

作者： Jessica Schira-Heinen Iria Samper Agrelo Veronica Estrada Patrick Küry Department of Neurology Neuroregeneration LaboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

The role of adult neural stem cells(NSCs)in demyelinating diseases of the central nervous system(CNS):Multipotent NSCs hold great potential for cell replacement in diseases and upon injury of the CNS.Originating from radial glial cells during nervous system development,adult NSCs are localized in the subgranular zone of the hippocampus and the subventricular zone(SVZ)of the lateral brain ventricles,the main neurogenic zones of the adult brain.Hippocampal precursor cells(type 1 cells)exhibiting properties of radial glial cells give rise to granule neurons through distinct intermediate precursor cells,and integrate into the hippocampal circuitry[reviewed by Kempermann et al.(2015)].Likewise,under physiological conditions,neuron generation by mouse SVZ-derived NSCs(also known as type B cells)is the predominant cell fate,which thereby results in large numbers of transient amplifying precursor cells(also known as type C cells)which in turn differentiate into neuroblasts(type A cells).These cells migrate along the rostral migratory stream into the olfactory bulb where they undergo maturation into local interneurons.The structure of the rodent SVZ differs from that of the human SVZ since the proliferative capacity is reduced,and migration of neuroblasts is a rare event in adult humans[reviewed by Lim and Alvarez-Buylla(2016)].

关键词： thereby migrate predominant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：