18β-Glycyrrhetinic Acid Improves Cardiac Diastolic Function by Attenuating Intracellular Calcium Overload
作者机构：Department of CardiologyWuhan Fourth HospitalPuai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430033China Department of CardiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2020年第40卷第4期
页 面：654-661页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 10[医学]
基 金：This project was supported by the National Natural Science Foundation of China(No.81600317 and No.81700345) the Open Foundation of Hubei Key Laboratory of Biological Targeted Therapy(No.02.03.2014-10)
主 题：glycyrrhetinic acid diastolic function calcium overload
摘 要：Summary:Ranolazine,a late sodium current inhibitor,has been demonstrated to be effective on heart failure.18B-glycyrrhetinic acid(18β-GA)has the similar inhibitory effect on late sodium ***,its effect on diastolic function is still *** study aimed to determine whether 18β-GA can improve the diastolic function and to explore the underlying *** male Sprague Dawley(SD)rats of Langendorff model were randomly divided into the following groups:group A,normal cardiac perfusion group;group B,ischemia-reperfusion group;group C,ischemia-reperfusion with anemoniasulcata toxinⅡ(ATX-Ⅱ);group D,ranolazine group;and group E,18β-GA group with four different ***,a pressure-overloaded rat model induced by trans-aortic constriction(TAC)was *** and hemodynamics were used to evaluate diastolic function at 14th day after *** of free intracellular calcium(Ca27)concentration was indirectly detected by laser scanning confocal microscope to confirm the inhibition of late sodium *** the intervention of ATX-Ⅱon ischemia reperfusion injury group,5 umol/L ranolazine,and 5,10,20,40μmol/L 18β-GA could improve ATX-I-induced cardiac diastolic dysfunction.630 mg/kg glycyrrhizin tablets could improve cardiac diastolic function in the pressure-overloaded rats.18B-GA and ranolazine had similar effects on reducing the free calcium in *** study demonstrates that 18B-GA and glycyrrhizin could improve diastolic dysfunction induced by ischemia-reperfusion injury in Langendorff-perfused rat hearts and pressure-overloaded *** mechanism may be attributed to the inhibition of enhanced late sodium currents.
维普期刊数据库