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MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-zhu Shen yong Zhang Fang Wu Mei-Zhen Shen Jun-Lin Liang Xiao-Long Zhang Xiao-Jian Liu Xin-Shu Li Ren-Sheng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(y)-regulated kinase 1A(DyRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DyRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

基于环境DNA技术的南极欺骗岛海域鱼类物种多样性

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水产学报 2024年第8期48卷 114-124页

作者：俞晔伟刘洋朱国平王丛丛上海海洋大学海洋科学学院上海海洋大学大洋渔业资源可持续开发教育部重点实验室上海海洋大学国家远洋渔业工程技术研究中心上海海洋大学农业农村部大洋渔业开发重点实验室上海海洋大学农业农村部大洋渔业资源环境科学观测实验站

欺骗岛是位于南极南设得兰群岛西南方向的火山岛，该岛附近海域受岛上活火山的影响显著，生物资源丰富。为探究该海域内鱼类物种组成，本实验通过对欺骗岛海域环境DNA (eDNA)样本采集、高通量测序开展鱼类物种多样性研究。结果显示，从... 详细信息

欺骗岛是位于南极南设得兰群岛西南方向的火山岛，该岛附近海域受岛上活火山的影响显著，生物资源丰富。为探究该海域内鱼类物种组成，本实验通过对欺骗岛海域环境DNA (eDNA)样本采集、高通量测序开展鱼类物种多样性研究。结果显示，从欺骗岛海域5个采样站点的环境样本中共检测出南极鱼类1目6科23属31种，调查得到的大部分鱼类物种均在以往南极传统渔业资源调查中出现。eDNA序列相对丰度最高的鱼类物种为裘氏鳄头冰鱼和花纹南极鱼，分别占鱼类总丰度的53.52%和28.27%。近岸站点和远岸站点间的α和β多样性的各项指数差异较大，但远岸站点间鱼类物种组成相差不大。研究表明，环境DNA技术作为传统渔业调查方法的补充，对环境干扰小，可以对欺骗岛海域鱼类物种多样性进行快速检测。本研究结果可为欺骗岛海域的鱼类多样性监测和渔业资源管理与保护提供数据支持。

关键词：鱼类环境DNA (eDNA) 渔业资源物种多样性欺骗岛

Reflections on COPD comorbidities

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Chinese Medical Journal 2024年第12期137卷 1504-1506页

作者： Zhenming He yue Wang Lin Shan yan Mou yunhuan Liu Guanhua Ma yanxu Wu Huili zhu Jeffrey L.Curtis Shilei Cui Haiyan Ge Department of Pulmonary and Critical Care Medicine Huadong HospitalFudan UniversityShanghai 200040China Medical Service VA Ann Arbor Healthcare SystemAnn ArborMI 48105USA Pulmonary&Critical Care Medicine Division Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA Graduate Program in Immunology University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic obstructive pulmonary disease(COPD)is a common disease among the elderly,affecting over one-third of the elderly population *** progressive decline in lung function characteristic of COPD significantly impacts the quality of life and employability of affected individuals,resulting in a substantial direct and indirect socioeconomic *** frequently has comorbidities involving other organ *** all elderly COPD patients present with one or more comorbid conditions,collectively exacerbating health and economic *** viral and bacterial infections remain the most common triggers for COPD exacerbations(ECOPD).

关键词： morbid lung collective

Relationship between the change of ATP level controlled by ectonucleotidases and endometriosisassociated infertility and pain

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Gynecology and Obstetrics Clinical Medicine 2024年第2期4卷 115-121页

作者： yiling Wang Qingjie Zhai Zhao Tian Xiaohong Chang Honglan zhu Department of Obstetrics and Gynecology Peking University People's HospitalBeijingChina

Background Thedysfunction ofthe immune system is one of the pathogeneses of *** cells can not onlyaffect the microenvironmentof the endometrium by secreting cytokines and defensins but also promote angiogenesis,growth and invasion of endometrial stromal *** ATP is a key mediator in the immune mechanism of endometriosis and plays a crucial role in *** ATP acts as a purinergic signaling molecule,it has a close relationship with the pain of endometriosis via activating ATP receptors,including P2X3,P2X4,P2X7 and P2y receptors,after being activated by the immune ***,ATP levels reflect the impairment of mitochondrial function in granulosa cells,which could lead to *** modulation of ATP expression levels is controlled by *** content of ectonucleotidases is altered in endometriosis which may be emerging non-invasive *** In the present review,we briefly introduce the relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain,and illustrate our prospects for future research.

关键词： endometriosis pain infertility

Planar Hall Effect in the Charge-Density-Wave Bi2Rh3Se2

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Chinese Physics Letters 2024年第7期41卷 131-136页

作者：蔡明桔陈正杨扬朱相德孙浩翔朱安康刘学韩玉岩高文帅田明亮 Institutes of Physical Science and Information Technology Anhui University Anhui Key Laboratory of Low-energy Quantum Materials and Devices High Magnetic Field LaboratoryHefei Institutes of Physical Science Chinese Academy of Sciences Stony Brook Institute at Anhui University Anhui University School of Mathematics and Physics Bengbu University School of Physics and Optoelectronics Engineering Anhui University

We systematically investigate in-plane transport properties of ternary chalcogenide *** rotating the magnetic field within the plane of the sample,one can distinctly detect the presence of both planar Hall resistance and anisotropic longitudinal resistance,and the phenomena appeared are precisely described by the theoretical formulation of the planar Hall effect （PHE）.In addition,anisotropic orbital magnetoresistance rather than topologically nontrivial chiral anomalies dominates the PHE in *** finding not only provides another platform for understanding the mechanism of PHE,but could also be beneficial for future planar Hall sensors based on two-dimensional materials.

关键词： Anisotropy

Converting intercalation-type cathode in spent lithium-ion batteries into conversion-type cathode

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Nano Research 2024年第5期17卷 4602-4609页

作者： Dingding zhu yong Su Jingzhao Chen Xiangze Ou Xuedong Zhang Wen Xie yuyan Zhou yunna Guo Qiushi Dai Peng Jia Jitong yan Lin Geng Baiyu Guo Liqiang Zhang yongfu Tang Qiao Huang Jianyu Huang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066000China

The widespread applications of lithium-ion batteries(LIBs)generate tons of spent ***,recycling LIBs is of paramount importance in protecting the environment and saving the *** commercialized LIBs mostly adopt layered oxides such as LiCoO_(2)(LCO)or LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)(NMC)as the cathode *** the intercalation-type spent oxides into conversion-type cathodes(such as metal fluorides(MFs))offers a valid recycling strategy and provides substantially improved energy densities for ***,two typical Co-based cathodes,LCO and LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NMC622),in spent LIBs were successfully converted to CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) cathodes by a reduction and fluorination *** as converted CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) delivered cell energy densities of 650 and 700 Wh/kg,*** atomic-level electron microscopy revealed that the used LCO and NMC622 were converted to highly phase pure Co metal and Ni_(0.6)Co_(0.2)Mn_(0.2) alloys in the used graphite-assisted reduction roasting,simultaneously producing the important product of Li_(2)CO_(3) using only environment friendly *** study provided a versatile strategy to convert the intercalation-type Co-based cathode in the spent LIBs into conversion-type MFs cathodes,which offers a new avenue to recycle the spent LIBs and substantially increase the energy densities of next generation LIBs.

关键词： spent lithium-ion batteries recycling energy densities conversion-type cathode

The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

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Biosafety and Health 2024年第2期6卷 101-115页

作者： yanan Wang Mengqi Qu yuhai Bi William J.Liu Sufang Ma Bo Wan yongfei Hu Baoli zhu Gaiping Zhang George F.Gao International Joint Research Center of National Animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu Laboratory Zhengzhou 450046China University of Chinese Academy of Sciences Beijing 100049China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene

明代藩王墓出土金凤簪的风格转折——以江西、湖北为考查中心

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装饰 2024年第5期 142-144页

作者：祝爱玉浙江理工大学

在明代封藩历史中,各藩王使用的器物机制及实物都带有深厚的时代和身份属性。其中金凤簪形制占有特殊地位,本文聚焦明代藩王墓出土的不同时期、不同地区样式相同的金凤簪,采用实物观察与古籍、文献、图像相结合的研究方法,从需求、样式... 详细信息

在明代封藩历史中,各藩王使用的器物机制及实物都带有深厚的时代和身份属性。其中金凤簪形制占有特殊地位,本文聚焦明代藩王墓出土的不同时期、不同地区样式相同的金凤簪,采用实物观察与古籍、文献、图像相结合的研究方法,从需求、样式、制作机构、生产模式等方面解读凤簪营造的背景,揭示江西、湖北两地出土金凤簪从早期细密累丝转向珍宝装饰,再到中晚期捶揲錾刻成型,形成时代风格艺术特征的转折,并分析该转折产生的历史原因,为宗藩金银营造制度研究提供了一个新的视角。

关键词：金银器明代藩王造物营造制度时代风格

Nomogram to predict severe retinopathy of prematurity in Southeast China

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-yong Li Hong-Wu He Ka-Lu Jin Ling-Xia Zhang yang Zhou Zhi-Min zhu Chen-Chen Jiang Hai-Jian Wu Sui-Lian Zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;Py univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)for the nomogram,32.9(95%CI,15.3-50.5)for WINROP model,70.2(95%CI,55.8-84.6)for Digirop-Birth *** external validation group,AUC of the nomogram was also higher than that of WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation