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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A Fine-Grained Runtime Power/Performance Optimization Method for Processors with Adaptive Pipeline Depth

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Journal of Computer Science & Technology 2011年第2期26卷 292-301页

作者：姚骏 Shinobu Miwa Hajime Shimada Shinji tomita Graduate School of Information Science Nara Institute of Science and Technology School of Engineering Tokyo University of Agriculture and Technology Graduate School of Informatics Kyoto University Institute for Integrated Cell-Material Sciences Kyoto University

Recently, a method known as pipeline stage unification （PSU） has been proposed to alleviate the increasing energy consumption problem in modern microprocessors. PSU achieves a high energy efficiency by employing a changeable pipeline depth and its working scheme is eligible for a fine control method. In this paper, we propose a dynamic method to study fine-grained program interval behaviors based on some easy-to-get runtime processor metrics. Using this method to determine the proper PSU configurations during the program execution, we are able to achieve an averaged 13.5% energydelay-product （EDP） reduction for SPEC CPU2000 integer benchmarks, compared to the baseline processor. This value is only 0.14% larger than the theoretically idealized controlling. Our hardware synthesis result indicates that the proposed method can largely decrease the hardware overhead in both area and delay costs, as compared to a previous program study method which is based on working set signatures.

关键词： dynamic optimization energy saving fine-grained pipeline stage unification workload analysis

Effective Isolation of Retrotransposons and Repetitive DNA Families from the Wheat Genome

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Journal of Integrative Plant Biology 2010年第7期52卷 679-691页

作者： Motonori tomita Munenori Asao Aya Kuraki Molecular Genetics Laboratory Faculty of AgricultureTottori University

New classes of repetitive DNA elements were effectively identified by isolating small fragments of the elements from the wheat genome. A wheat A genome library was constructed from Triticum monococcum by degenerate cleavage with EcoO1091, the recognition sites of which consisted of 5＇-PuGGNCCPy-3＇ multi-sequences. Three novel repetitive sequences pTm6, pTm69 and pTm58 derived from the A genome were screened and tested for high copy number using a blotting approach, pTm6 showed identity with integrase domains of the barley Tyl-Copia-retrotransposon BARE-1 and pTm58 showed similarity to the barley Ty3-gypsy-like retrotransposon Romani. pTm69, however, constituted a tandem array with useful genomic specificities, but did not share any identity with known repetitive elements. This study also sought to isolate wheat D-genome-specific repetitive elements regardless of the level of methylation, by genomic subtraction. Total genomic DNA of Aegilops tauschii was cleaved into short fragments with a methylation-insensitive 4 bp cutter, Mbol, and then common DNA sequences between Ae. tauschii and Triticum turgidum were subtracted by annealing with excess T. turgidum genomic DNA. The D genome repetitive sequence pAt1 was isolated and used to identify an additional novel repetitive sequence family from wheat bacterial artificial chromosomes with a size range of 1 395-1 850 bp. The methods successfully led pathfinding of two unique repetitive families.

关键词： DNA Effective Isolation of Retrotransposons and Repetitive DNA Families from the Wheat Genome AABB

β-Arrestin 1(ARRB1) serves as a molecular marker of the peripheral circadian rhythm

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International Journal of Oral Science 2019年第4期11卷 307-314页

作者： Tatsunosuke tomita Taisuke Mori yoshiaki Onishi Biomedical Research Institute National Institute of Advanced Industrial Science and Technology(AIST)DBT-AIST International Laboratory for Advanced Biomedicine(DAILAB)Higashi 1-1-1TsukubaJapan Molecular Pathology Division and Diagnostic Pathology Division National Cancer Center Research InstituteTsukiji 5-5-1Chuo-kuTokyoJapan

The control of the circadian rhythm is important for health because it regulates physiological functions and is associated with health *** aimed to identify a circadian biomarker of health status in human saliva,since collecting saliva is non-invasive,straightforward,and *** 500 genes potentially controlled by the salivary clock identified using chromatin immunoprecipitation(ChIP)assays,22 of them showed reasonable transcriptional responses according to a DNA array in a salivary model *** these 22 genes,ARRB1,which is expressed in human salivary glands,was also expressed in model HSG cells at the transcriptional and translational *** profile of ARRB1 expression in human saliva was circadian,suggesting that ARRB1 could serve as a candidate circadian biomarker in *** compared ARRB1 with other biomarkers in salivary samples from jetlagged *** circadian profile of ARRB1 reflected the time lag more than the profile of melatonin,whereas the profiles of cortisol andα-amylase did not reflect the time ***,these findings suggest that salivary ARRB1 could serve as a candidate biomarker that could be used to monitor the internal body clock.

关键词： salivary circadian straight

Cooling Curve's Effect on Hardening Behavior of Steel

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材料热处理学报 2004年第5期25卷 462-464页

作者： Kazuto Fukuhara Shigeru Asada yoshihiro tomita Syusaku Maeda Nippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka Japan

Quenching Oils are comprised mostly of mineral oil as major component, but mineral oil alone result in lower cooling performance. Therefore, various additives are formulated as required for each particular case. Cooling curves of mineral oil as determined by JIS method can be divided into three stages, vapor film stage, boiling stage and convection stage. And there are many types of additives used for quenching oil, one effective to shorten vapor film stage and another to shift boiling stage toward lower temperature side. As rapid quenching required temperature range for particular steel varies pending on its shape of CCT curve"1, it is possible to provide higher quench hardening performance using quenching oil formulated of adequate additives.

关键词：淬火油冷却效果硬化性能钢

Low-velocity pneumatic conveying in horizontal pipe for coarse particles and fine powders

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Particuology 2008年第5期6卷 316-321页

作者： yuji tomita Vijay Kumar Agarwal Hiroyuki Asou Katsuya Funatsu Kyushu Institute of Technology 1-1 SensuichoTobataKitakyushu 804-5500Japan Indian Institute of Technology Hauz KhasNew Delhi 110016India

First, the characteristics of low-velocity conveying of particles having different hardness are experimentally investigated in a horizontal pipeline in terms of flow pattern and pressure drop to show that the slug flow can be classified into two types depending on the settling of particles along the pipeline, and the period is small for slug flow without the settled layer, which is called solitary slug flow. The pressure drop for soft particles is shown to be larger than that for hard particles. Then, experimental results are presented on horizontal fluidized-bed conveying of fine powders to show that air release from the top surface of the conveying channel is an imnortant factor for high mass flow rate of particles.

关键词： Low-velocity conveying Slug flow Soft particle Horizontal fluidized-bed conveying Fine powder

Pemafibrate,a potent selective peroxisome proliferator-activated receptorαmodulator,a promising novel treatment for ischemic retinopathy?

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Neural Regeneration Research 2023年第7期18卷 1495-1496页

作者： UCCAODeokhoLee yohei tomita Kazuno Negishi Toshihide Kurihara Department of Ophthalmology Keio University School of MedicineShinanomachiShinjuku-kuJapan

Ischemic retinopathy is a retinal disease caused by ischemic *** is a common pathologic mechanism in various retinal disorders and diseases such as age-related macular degeneration,diabetic retinopathy,glaucoma,or vascular occlusion(Osborne et al.,2004).Although various murine models have been developed to understand a series of metabolic mechanisms induced by retinal ischemia and further used to test promising therapeutics,effective treatment in ischemic retinopathy has not been clearly *** is associated with the notion that the contributing pathologic metabolic pathways might be enormously complex.

关键词： retinopathy degeneration

Acceleration of Dust Particle in SOL/Divertor Plasma of HL-2A

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Plasma Science and Technology 2009年第4期11卷 427-429页

作者： yukihiro tomita Gakushi KAWAMURA 潘宇东周艳严龙文 National Institute for Fusion Science Southwestern Institute of Physics

Acceleration of a dust particle in the SOL （scrape-off layer）/divertor plasma of HL- 2A with a single-null configuration is studied. A simplest model of the dust dynamics is applied, namely spherical shape of a dust, ion drag force due to Coulomb scattering as a dominant force, and spontaneous charging of a dust particle to the equilibrium charge. In the outer region near the plasma-facing wall the poloidal plasma flow pushes the dust particle to the divertor plates. It is clarified that the dust particle with a radius of 1 μm from the top of the SOL/divertor region is accelerated up to around 100 m/s at the divertor plates along the poloidal direction .

关键词： dust particle HL-2A poloidal flow B2-EIRENE

Aboveground biomass and seasonal patterns of aboveground net primary productivity in five bamboo species in northern Laos

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Journal of Plant Ecology 2020年第2期13卷 150-156页

作者： Singkone Xayalath Isao Hirota Shinsuke tomita Michiko Nakagawa Department of Forest and Environmental Resource Sciences Graduate School of Bioagricultural SciencesNagoya UniversityNagoya 464-8601Japan Department of Agricultural and Environmental Science Faculty of Applied Biological SciencesGifu UniversityGifu 501-1193Japan Asian Satellite Campuses Institute Nagoya UniversityNagoya 464-8601Japan

Aims Accurate estimates of bamboo biomass and net primary productivity(NPP)are required to evaluate the carbon sequestration potential of bamboo ***,relevant data that are important for climate change mitigation,have rarely been collected in regions outside of East Asia and *** on seasonal patterns of NPP and its components will enable the quantification of factors that influence the carbon balance in bamboo *** this study,we quantified the aboveground biomass(AGB)and aboveground NPP of five major bamboo species in northern Laos using monthly data collected over a 12-month *** All live culms in 10,2 m×2 m plots(for one monopodial bamboo species:Indosasa sinica)and 30 clumps per species(for four sympodial bamboo species:Bambusa tulda,Cephalostachyum virgatum,Dendrocalamus membranaceus and Gigantochloa sp.)were numbered and measured at breast *** set 10 or 20 litter traps per species to collect *** of dead and recruited culms and litterfall collection were performed once per month for 12 *** Findings The AGB was highest in ***(59.87 Mg ha^(-1))and lowest in ***(11.54 Mg ha^(-1)),and was mostly below the plausible global range for bamboos(32–256 Mg ha^(-1)).The sympatric distribution of multiple bamboo species at the study sites may have suppressed the AGB in four of the five studied *** aboveground NPP estimates were between 3.43 and 14.25 Mg ha^(-1) yr^(-1);those for ***(8.20 Mg ha^(-1) yr^(-1))and ***(14.25 Mg ha^(-1) yr^(-1))were comparable to mean global estimates for temperate evergreen forests(8.78 Mg ha^(-1) yr^(-1))and tropical moist forests(10.56 Mg ha^(-1) yr^(-1)).High culm recruitment rates(15.20–23.39%yr^(-1))were major contributors to aboveground NPP *** patterns of aboveground NPP were largely influenced by the phenology of the new *** the four sympodial bamboo species,new culms began to emerge following the onset of per

关键词： bamboo forest carbon sequestration culm dynamics litterfall northern Laos seasonality

Prevention of explosion in coal mine and management of coal mine gas

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Journal of Coal Science & Engineering(China) 2009年第2期15卷 215-219页

作者： FURUKAWA Hirofumi tomita Shinji Japan Coal Energy Center (JCOAL)

There are many problems in terms of safe coal production and the sound developmentof the coal *** the intensification and increasing efficiencyof coal production and the conducting of mining operations at deeper and more remoteareas of mines,the efficient recovery and utilization of Coal Mine Methane:(CMM) is animportant issue in improving and stabilizing the productivity in the coal mining industry withhigh levels of gas,where the incidence of gas outbursts is *** plan to studyvarious aspects of the development of production technology and characteristics of themine *** is to establish the technology for highly efficient coproduction coal and gasoperation *** a result,the productivity at the coal mine face will increase due to thereduction in gas emissions in the mining *** use of recovered gas can be expectedto reduce global warming by reducing the amount of coal mine methane gas emissionin the air.

关键词： coal mine methane coproduction coal and gas global warming