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A Mathematical Model for the Heat Radiation Characteristics of Materials

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Journal of Thermal Science 2004年第1期13卷 75-79页

作者： D. H. Xia y. H. wu Univ Sci & Technol Beijing Dept Thermal Engn Beijing 100083 Peoples R China

Based on the model of harmonic oscillators, a mathematical model for the heat radiation characteristics of materials such as semiconductors, metals, plasmas and ionic cry.tals is established in this paper. The main factors affecting the heat radiation characteristics of materials are also analy.ed at length. The emissivity.is calculated for revealing the mechanism of emitting, absorbing, transmitting and reflecting the heat radiation wave.

关键词： harmonic oscillator mathematical Model heat radiation wave emissivity.

A Two-Dimensional Architecture for Fast Large-Scale Trapped-Ion Quantum Computing

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Chinese Phy.ics Letters 2020年第7期37卷 5-10页

作者： y.-K.wu L.-M.Duan Center for Quantum Information IIISTsinghua UniversityBeijing 100084China

Building blocks of quantum computers have been demonstrated in small to intermediate-scale *** one of the leading platforms,the trapped ion sy.tem has attracted wide attention.A significant challenge in this sy.tem is to combine fast high-fidelity.gates with scalability.and convenience in ion trap *** we propose an architecture for large-scale quantum computing with a two-dimensional array.of atomic ions trapped at such large distance which is convenient for ion-trap fabrication but usually.believed to be unsuitable for quantum computing as the conventional gates would be too *** gate operations far outside of the Lamb–Dicke region,we show that fast and robust entangling gates can be realized in any.large ion *** gate operations are intrinsically.parallel and robust to thermal noise,which,together with their high speed and scalability.of the proposed architecture,makes this approach an attractive one for large-scale quantum computing.

关键词： Quantum computer operations

A DNA delivery.sy.tem containing listerioly. in Oresults in enhanced hepatocy.edirected gene expression

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World Journal of Gastroenterology 1999年第6期5卷 465-469页

作者： Cherie M. Walton, Catherine H. wu and George y. wu Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT United States Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT 06030 United States

AIM To determine whether incorporation of the pH dependent bacterial toxin listerioly.in O (LLO) into the DNA carrier sy.tem could increase the endosomal escape of internalized DNA and result gene expression. METHODS A multi component delivery.sy.tem was prepared consisting of asialogly.oprotein (ASG), poly.L ly.ine (PL), and LLO. Two marker genes, luciferase and β galactosidase in plasmids were complexed and administered in vitro to Huh7[ASG receptor (+) ] and SK Hep1[ASG receptor (-) ] cells. Purity. hemoly.ic activity. gene expression, specificity. and toxicity.were evaluated. RESULTS An LLO containing conjugate retained cell targeting specificity.and membranoly.ic activity. In ASG receptor (+) cells, luciferase gene expression was enhanced by.more than 7 fold over that of conjugates without the incorporation of listerioly.in O. No significant expression occurred in ASG receptor (-) cells. Enhancement of β galactosidase gene expression was less, but still significantly.increased over controls. There was no detectable toxicity.at concentrations shown to be effective in transfection studies. CONCLUSIONS ASOR PL can be coupled to LLO using disulfide bonds, and successfully.target and increase the gene expression of foreign DNA.

关键词： DNA gene expression listerioly.in O hepatocy.es

HEV and HBV Dual Infection:A Review

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 313-321页

作者： My.a Nasir George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Hepatitis E virus(HEV)is a global health problem,affecting about 20 million people *** is significant overlap of hepatitis B virus(HBV)and HEV endemicity.in many.Asian countries where dual infections with HEV and HBV can *** the clinical course of HEV is largely.self-limited,HEV superinfection in patients with chronic hepatitis B(CHB)can result in acute exacerbation of underly.ng *** superinfection in patients with CHB-related cirrhosis has been identified as a risk factor for decompensated cirrhosis and an independent predictor of *** acute HEV infection in pregnancy.can cause fulminant liver failure,the few studies on pregnant patients with dual HBV and HEV infection have shown a subclinical *** is a risk factor for the development of chronic HEV infection,which can be managed by.decreasing the dose of immune-suppressants and administering *** for HEV has been developed and is in use in China but its efficacy.in patients with CHB has y.t to be established in the *** this review,we appraise studies on dual infection with HEV and HBV,including the effect of HEV superinfection and coinfection in CHB,management strategies used and the role of active vaccination in the prevention of HEV.

关键词： Hepatitis B Hepatitis E Coinfection Superinfection Chronic hepatitis B

Primary.Sclerosing Cholangitis and Primary.Biliary.Cirrhosis Overlap Sy.drome:A Review

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 336-346页

作者： Sheena Mago George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Primary.sclerosing cholangitis(PSC)and primary.biliary.cirrhosis(PBC)are slow progressive diseases which have been increasing in *** pathogeneses of PBC and PSC are incompletely.understood but the underly.ng mechanisms appear to be fundamentally.autoimmune in *** PBC and PSC appear to be separate entities,overlap has been *** depends on a combination of serological markers,imaging,and pathological *** mainstay.of treatment has been ursodeoxy.holic acid and in some cases of extrahepatic biliary.obstruction and overlap disorder,endoscopic retrograde cholangiopancreatography.has been useful.

关键词： Primary.sclerosing cholangitis Primary.biliary.cirrhosis Overlap sy.drome

A betatron tune measurement sy.tem based on bunch-by.bunch transverse feedback at the Duke storage ring

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Chinese Phy.ics C 2013年第7期37卷 76-82页

作者：徐卫 W. Z. wu 李京祎何多慧 y. K. wu National Sy.chrotron Radiation Laboratory.(NSRL) University of Science and Technology of China FEL Laboratory TUNL and Department of Physics Duke University

To combat electron beam instabilities, a digital bunch-by.bunch transverse feedback （TFB） sy.tem has been developed for the Duke storage ring. While it is capable of suppressing transverse beam instabilities for multibunch operation, the TFB sy.tem has not been needed for ty.ical operation of the Duke storage ring. To explore the great potential of this sy.tem, we have developed beam diagnostic techniques using the TFB, in particular, the TFB based tune measurement techniques. The tune measurement technique allows us to conduct fast chromaticity.measurements, compared with the existing chromaticity.measurement sy.tem using a network analy.er. This new tune measurement sy.tem also enables us to measure the bunch tune for multibunch operation of the Duke storage ring. With the TFB based tune measurement sy.tem, we have studied the tune stability.of the electron beam in the Duke storage ring. This tune sy.tem has also been used to calibrate the tune knob for the Duke storage ring.

关键词： transverse feedback tune chromaticity

Celiac Disease and Elevated Liver Enzy.es: A Review

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 116-124页

作者： Jaimy.Villavicencio Kim George y.wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology.epatology University of Connecticut Health CenterFarmingtonCTUSA

Aminotransferases are commonly.found to be elevated in patients with celiac disease in association with two different ty.es of liver dy.function:cry.togenic liver disorders and autoimmune *** purpose of this review is to discuss the mechanisms by.which aminotransferases become elevated in celiac disease,clinical manifestations,and response to gluten-free *** studies have shown that celiac patients with cry.togenic liver disease have normalization in aminotransferases,intestinal histologic improvement and serologic resolution after 6–12 months of strict gluten-free *** patients with an underly.ng autoimmune liver disease,simultaneous treatment for both conditions resulted in normalized elevated *** literature suggests that intestinal permeability.may.be at least one of the mechanisms by.which liver damage *** with celiac disease should have liver enzy.es routinely.checked and treated with a strict gluten-free diet if found to be *** of improvement in patients who have strictly.adhered to gluten-free diet should prompt further workup for other causes of liver disease.

关键词： Celiac disease Gluten free diet Celiac hepatitis Autoimmune liver disease

Cy.omegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 106-115页

作者： Teresa Da Cunha George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA

Human cy.omegalovirus (HCMV) infection is common and affects between 40–100% of the worldwide population. However, the majority.of cases are asy.ptomatic and when severe disease occurs, it is usually.restricted to immunocompromised patients. Liver involvement by.HCMV differs significantly. accordingly.to the immune status of the host. In immunocompromised patients, particularly.liver transplant patients, it often causes clinically.significant hepatitis. On the other hand, in immunocompetent patients, HCMV hepatitis requiring hospitalization is extremely.rare. This review aims to appraise studies regarding the pathophy.iology.of HCMV hepatitis, including mechanisms of latency.and reactivation and its contribution to disease development, clinical presentation, diagnostic modalities and treatment, with a focus on comparing different aspects between immunocompromised and immunocompetent hosts.

关键词： CMV hepatitis Cy.omegalovirus hepatitis Cy.omegalovirus hepatitis immunocompetent Cy.omegalovirus hepatitis immunocompromised

A crowd route choice evacuation model in large indoor building spaces

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Frontiers of Architectural Research 2018年第2期7卷 135-150页

作者： y. wu J. Kang C. Wang School of Architecture Harbin Institute of Technology Harbin 150001 PR China School of Architecture University of Sheffield Sheffield S10 2TN UK School of Architecture Tianjin University Tianjin 300072 PR China

Route choice is a fundamental requirement in the evacuation process. The aim of this paper is to identify.a method to simulate crowds in large indoor spaces with consideration of the acoustic sy.tem. This paper first extends an existing cellular automaton model and proposes a ceUutar automaton crowd route choice model （CACR model） to simulate evacuees in large indoor spaces. It then defines a measure for evaluating the utility.of evacuation time using the CACR model under different circumstances, such as a fire situation or different voice warning sy.tems, which other commercial models cannot simulate. The analy.is of the characteristics of a sound field in large indoor spaces is based on field measurements. An observation experiment in a gy.nasium is employ.d to test the proposed model in a stadium evacuation scenario. The results demonstrate that the CACR model can accurately.simulate the evacuation process in large indoor spaces under various circumstances.

关键词： Crowd Evacuation Cellular automatonmodel Sound Voice warning sy.tem