HEV and HBV Dual Infection:A Review
作者机构：Department of MedicineDivision of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2020年第8卷第3期
页 面：313-321页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：Herman Lopata Chair in Hepatitis
主 题：Hepatitis B Hepatitis E Coinfection Superinfection Chronic hepatitis B
摘 要：Hepatitis E virus(HEV)is a global health problem,affecting about 20 million people *** is significant overlap of hepatitis B virus(HBV)and HEV endemicity in many Asian countries where dual infections with HEV and HBV can *** the clinical course of HEV is largely self-limited,HEV superinfection in patients with chronic hepatitis B(CHB)can result in acute exacerbation of underlying *** superinfection in patients with CHB-related cirrhosis has been identified as a risk factor for decompensated cirrhosis and an independent predictor of *** acute HEV infection in pregnancy can cause fulminant liver failure,the few studies on pregnant patients with dual HBV and HEV infection have shown a subclinical *** is a risk factor for the development of chronic HEV infection,which can be managed by decreasing the dose of immune-suppressants and administering *** for HEV has been developed and is in use in China but its efficacy in patients with CHB has yet to be established in the *** this review,we appraise studies on dual infection with HEV and HBV,including the effect of HEV superinfection and coinfection in CHB,management strategies used and the role of active vaccination in the prevention of HEV.
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