Cytomegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts

作     者：Teresa Da Cunha George Y.Wu Teresa Da Cunha;George Y. Wu

作者机构：Department of MedicineDivision of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of MedicineUniversity of Connecticut Health CenterFarmingtonCTUSA 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2021年第9卷第1期

页      面：106-115页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Herman Lopata Chair in Hepatitis Research 

主　　题：CMV hepatitis Cytomegalovirus hepatitis Cytomegalovirus hepatitis immunocompetent Cytomegalovirus hepatitis immunocompromised 

摘      要：Human cytomegalovirus (HCMV) infection is common and affects between 40–100% of the worldwide population. However, the majority of cases are asymptomatic and when severe disease occurs, it is usually restricted to immunocompromised patients. Liver involvement by HCMV differs significantly, accordingly to the immune status of the host. In immunocompromised patients, particularly liver transplant patients, it often causes clinically significant hepatitis. On the other hand, in immunocompetent patients, HCMV hepatitis requiring hospitalization is extremely rare. This review aims to appraise studies regarding the pathophysiology of HCMV hepatitis, including mechanisms of latency and reactivation and its contribution to disease development, clinical presentation, diagnostic modalities and treatment, with a focus on comparing different aspects between immunocompromised and immunocompetent hosts.