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3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie liu xuqiang liu Kaiyue He Yongping Jian Yujia Li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of Life Sciences Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China Shenzhen Research Institute of Henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK Hepatocellular carcinoma

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微秒到秒时间尺度的高压相变动力学和物性研究:回顾、进展及展望

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高压物理学报 2024年第3期38卷 1-19页

作者：王毫赵婷婷李梅李俊龙彭赏刘旭强赵博浩陈彦龙林传龙北京高压科学研究中心北京100193

近年来,基于金刚石对顶砧的快速加载技术(如动态金刚石对顶砧)和时间分辨探测技术的快速发展为高压科学研究开辟了新的研究方向和思路。这些技术使得科学家能够探索微秒到秒级时间尺度的高压非平衡物理过程,填补了静高压与动态冲击波实... 详细信息

近年来,基于金刚石对顶砧的快速加载技术(如动态金刚石对顶砧)和时间分辨探测技术的快速发展为高压科学研究开辟了新的研究方向和思路。这些技术使得科学家能够探索微秒到秒级时间尺度的高压非平衡物理过程,填补了静高压与动态冲击波实验之间的空白。本文回顾并总结了近年来在快速加载和时间分辨探测技术上的进展,详细探讨了依赖于加载速率的结构相变动力学、相变途径、亚稳相的形成、微结构、力致发光等现象。希望通过深入思考和系统归纳微秒至秒级时间尺度的高压科学问题和技术挑战,为高压科学领域的研究者提供新的启示和参考。

关键词：高压动态金刚石对顶砧快速压缩加载速率相变动力学亚稳相

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Flowers: precious food and medicine resources

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Food Science and Human Wellness 2023年第4期12卷 1020-1052页

作者： xuqiang liu Senye Wang Lili Cui Huihui Zhou Yuhang liu Lijun Meng Sitan Chen Xuefeng Xi Yan Zhang Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China College of Physical Education Henan UniversityKaifeng 475004China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Shenzhen Research Institute of Henan University Shenzhen 518000China

Flower plants are popular all over the world and important sources of ornamental plants,bioactive molecules and *** have a wide range of biological activities and beneficial pharmacological *** and their active ingredients are becoming more and more popular in the preparation of food,drugs and industrial *** paper summarizes the active ingredients,pharmacological activities and applications in the pharmaceutical and food industries of flower plants in recent *** addition,the possible molecular mechanism of pharmacological effects of flower plants were also discussed.302 active constituents from 55 species of flower plants were summarized,including flavonoids(115),terpenoids(90),phenylpropanoids(20),alkaloids(13),organic acids(27)and others(37).The pharmacological effects of flower plants are very extensive,mainly including antioxidant,anti-inflammatory,anti-tumor,anti-virus,and *** mechanisms of anti-inflammatory,anti-tumor and hypoglycemic activities present the characteristics of multi-way and *** of its rich nutrients,bioactive ingredients and plant essential oils,and its wide sources,flower plants are widely used in food,beverage,cosmetics and drug *** plants also play an important role in pharmaceutical industry,food industry and other fields.

关键词： Flowers Active ingredients Biological activity Mechanism

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Numerical Simulations of the Flow Field around a Cylindrical Lightning Rod

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Structural Durability & Health Monitoring 2024年第1期18卷 19-35页

作者： Wei Guo Yanliang liu xuqiang Wang Jiazheng Meng Mengqin Hu Bo He State Grid Ningxia Ultra High Voltage Co. Ltd.Yinchuan750000China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China

As an important lightning protection device in substations,lightning rods are susceptible to vibration and potential structural damage under wind *** order to understand their vibration mechanism,it is necessary to conduct flow *** this study,numerical simulations of the flow field around a 330 kV cylindrical lightning rod with different diameters were performed using the SST k-ω*** flow patterns in different segments of the lightning rod at the same reference wind speed(wind speed at a height of 10 m)and the flow patterns in the same segment at different reference wind speeds were *** variations of lift coefficient,drag coefficient,and vorticity distribution were *** results showed that vortex shedding phenomena occurred in all segments of the lightning rod,and the strength of vortex shedding increased with decreasing *** vorticity magnitude and the root mean square magnitudes of the lift coefficient and drag coefficient also increased *** time history curves of the lift coefficient and drag coefficient on the surface of the lightning rod exhibited sinusoidal patterns with a single dominant *** the same segment,as the wind speed increased in a certain range,the root mean square values of the lift coefficient and drag coefficient decreased,while their dominant frequencies ***,there was a proportional relationship between the dominant frequencies of the lift coefficient and drag *** findings of this study can provide valuable insights for the refined design of lightning rods with similar structures.

关键词： Lightning rod flow around circular tubes numerical simulation vortex shedding phenomenon

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Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo

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Acta Pharmaceutica Sinica B 2022年第2期12卷 890-906页

作者： Yan Zhang Pin Lv Junmei Ma Ning Chen Huishan Guo Yan Chen Xiaoruo Gan Rong Wang xuqiang liu Sufang Fan Bin Cong Wenyi Kang Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Cardiovascular Medical Science Center Department of Cell BiologyHebei Medical UniversityShijiazhuang 050017China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology Chinese Academy of Medical SciencesBeijing 100730China

Antrodia cinnamomea is extensively used as a traditional medicine to prevention and treatment of liver ***,its comprehensive chemical fingerprint is uncertain,and the mechanisms,especially the potential therapeutic target for anti-hepatocellular carcinoma(HCC)are still *** UPLC-Q-TOF/MS,139 chemical components were identified in *** dropping pills(ACDPs).Based on these chemical components,network pharmacology demonstrated that the targets of active components were significantly enriched in the pathways in cancer,which were closely related with cell proliferation ***,HCC data was downloaded from Gene Expression Omnibus database(GEO).The Cancer Genome Atlas(TCGA)and Dis Ge NET were analyzed by bioinformatics,and 79 biomarkers were ***,nine targets of ACDP active components were revealed,and they were significantly enriched in PI3 K/AKT and cell cycle signaling *** affinity between these targets and their corresponding active ingredients was predicted by molecular ***,in vivo and in vitro experiments showed that ACDPs could reduce the activity of PI3 K/AKT signaling pathway and downregulate the expression of cell cycle-related proteins,contributing to the decreased growth of liver ***,PI3 K/AKT-cell cycle appears as the significant central node in anti-liver cancer of ***.

关键词： Antrodia cinnamomea UPLC-Q-TOF/MS Anti-hepatocellular carcinoma Network pharmacology PI3K/AKT Cell cycle

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Enoxacin-loaded Poly(lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption

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Journal of Materials Science & Technology 2016年第9期32卷 865-873页

作者： Yang Li xuqiang liu Lili Tan Ling Ren Peng Wan Yongqiang Hao Xinhua Qu Ke Yang Kerong Dai Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Department of Orthopedics First Affiliated Hospital of Nanchang UniversityArtificial Joint Engineering and Technology Research Center of Jiangxi Province Institute of Metal Research Chinese Academy of Sciences

Implant-associated infection remains a difficult medical problem in orthopedic surgery. Therefore, the development of multifunctional bone implants for treating infection and regenerating lost bone tissue, which may be a result of infection, is important. In the present study, we report the fabrication of enoxacin- loaded poly （lactic-co-glycolic acid）（PLGA） coating on porous magnesium scaffold （Enox-PLGA-Mg） which combine the favorable properties of magnesium, the antibacterial property and the effect of inhibition of osteoclastic bone resorption of enoxacin. The drug loaded PLGA coating of Mg scaffold enables higher drug loading efficiency （52%-56%） than non-coating enoxacin loaded Mg scaffold （Enox-Mg）（4%-5%）. Enox- PLGA-Mg exhibits sustained drug release for more than 14 days, and this controlled release of enoxacin signifcantly inhibits bacterial adhesion and prevented biofilm formation by Staphylococcus epidermidis （ATCC35984） and Staphylococcus aureus （ATCC25923）. Biocompatibility tests with Balb/c mouse embryo fibroblasts （Balb/c 3T3 cells） indicate that PLGA-Mg has better biocompatibility than Mg. Finally, we also demonstrate that Enox-PLCA-Mg extract potently inhibited osteoclast formation in vitro. Therefore, Enox- PLCA-Mg has the potential to be used as a multifunctional controlled drug delivery system bone scaffolds to prevent and/or treat orthopedic peri-implant infections.

关键词： Porous magnesium scaffold Poly (lactic-co-glycolic acid) (PLGA)Drug delivery system Bactericidal activity Enoxacin Osteolysis

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Prediction of Grinding Granularity Based on the Combination of Grey Model and Neural Network

Prediction of Grinding Granularity Based on the Combination ...

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第30届中国控制与决策会议

作者： ZHANG Yong liu xuqiang Electronic and Information Engineering University of Science and Technology Liaoning

The beneficiation process is an important production process of smelting economic indicators,and a process of dressing production grinding and classification plays a vital role in the beneficiation process,the grinding particle size is an important index of grinding production in the production process,not only affects the concentrate grade and recovery rate and subsequent *** key factors in the grinding *** grinding production process is a very complex control *** are many interference factors,large inertia and serious *** prediction cost is high and the prediction error is very *** on the analysis of the structure and characteristics of GM（1,N） grey prediction model,the grey prediction model is applied to predict the grinding granularity and the prediction error is compensated by neural *** experimental results show that the predicted values obtained by using the constructed grey model and the neural network for error compensation are closer to the actual ***,the learning time is short,the amount of data needed is small,and the running speed is fast,which can meet the requirements of subsequent processes.

关键词： Grinding granularity GM(1,N) model neural network error compensation

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复杂地层地铁盾构井施工土体竖向变形规律

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铁道工程学报 2023年第5期40卷 102-109页

作者：李炜明朱义王慕鸿连杰刘旭强吴政武汉轻工大学武汉430023 中铁二十二局集团轨道工程有限公司北京100040

研究目的:复杂地层大直径地铁盾构井基坑施工过程中,土体变形受到诸多因素影响,具有显著的地区、形状等差异性,有必要基于施工前的数值模拟与施工中的监测数据,进行施工土体变形规律研究。研究结论:(1)基于假设条件与工程简化模型,对于... 详细信息

研究目的:复杂地层大直径地铁盾构井基坑施工过程中,土体变形受到诸多因素影响,具有显著的地区、形状等差异性,有必要基于施工前的数值模拟与施工中的监测数据,进行施工土体变形规律研究。研究结论:(1)基于假设条件与工程简化模型,对于本工程初始方案的12个典型工况进行了数值模拟,基坑长边、短边方向上12个施工步可能出现的最大竖向变形分别为17.21 mm、50.81 mm,应在施工过程进行实时监测;(2)施工过程中,监测竖向变形最大值为28.01 mm,已接近工程允许值30.00 mm,建议适当延长监测周期;(3)对于本工程而言,监测区段的竖向变形在空间上与理论曲线较为接近,并随盾构井开挖深度增加而增大,同时因为监测点布置空间距离较小等因素影响,监测数据在空间上未能形成空间上的完整沉降槽;(4)数值模拟与工程实际存在差异,而施工监测由于多类条件限制,数据通常不完备,施工中二者应相互补充;(5)本研究成果可为类似地铁基坑工程的土体竖向变形规律研究提供参考。

关键词：地铁施工土体变形基坑监测数值模拟规律分析

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Grinding Granularity Prediction Based on Improved Particle Swarm Optimization and Gray RBF Neural Network Model

Grinding Granularity Prediction Based on Improved Particle S...

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第30届中国控制与决策会议

作者： liu xuqiang ZHANG Yong WANG Siqi Electronic and Information Engineering University of Science and Technology Liaoning Majoring in measurement and control technology and instruments school of automationBeijing university of science and technology

Grinding technology is an important part of mineral processing,in which grinding particle size is an important production index in grinding classification operation,which is directly related to concentrate grade and metal recovery rate in mineral processing ***,controlling grinding particle size is the key to the whole grinding ***,grinding process is a rather complex physical and chemical processwith many interference factors,large inertia and serious non-linearity,mutual constraints,making the grinding particle size prediction *** analyzing the structure and characteristics of grey dynamic prediction model and RBF neural network prediction,grey neural network prediction model is used to predict grinding particle size,which realizes the complementary advantages of grey prediction and neural network,and using the particle swarm algorithm to optimize the grey neural network *** experimental results show that the grey neural network has the advantages of small amount of data needed for prediction,small amount of calculation,can complement the advantages of the two,achieve better precision of grinding particle size prediction,and adjust the parameters of the grey neural network by using the improved particle swarm optimization algorithm,so as to obtain the optimal training parameters,and greatly improve the grinding particle size prediction accuracy.

关键词： Improved particle swarm optimization (PSO) Grey prediction RBF neural network Grinding granularity

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Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

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