Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo

作     者：Yan Zhang Pin Lv Junmei Ma Ning Chen Huishan Guo Yan Chen Xiaoruo Gan Rong Wang Xuqiang Liu Sufang Fan Bin Cong Wenyi Kang Yan Zhang;Pin Lv;Junmei Ma;Ning Chen;Huishan Guo;Yan Chen;Xiaoruo Gan;Rong Wang;Xuqiang Liu;Sufang Fan;Bin Cong;Wenyi Kang

作者机构：Hebei Key Laboratory of Forensic MedicineCollege of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key LaboratoryHebei Food Inspection and Research InstituteShijiazhuang 050091China Cardiovascular Medical Science CenterDepartment of Cell BiologyHebei Medical UniversityShijiazhuang 050017China National R&D Center for Edible Fungus Processing TechnologyHenan UniversityKaifeng 475004China Research Unit of Digestive Tract Microecosystem Pharmacology and ToxicologyChinese Academy of Medical SciencesBeijing 100730China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第2期

页      面：890-906页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Key Research Project of China(2019YFC1606400) CAMS Innovation Fund for Medical Sciences(2019-I2M-5-055,China) Major Public Welfare Projects in Henan Province(201300110200,China) National Key Research Project of Hebei Province(20375502D,China) Natural Science Foundation of Hebei Province(H2019206212,China) High-level Talent Funding Project of Hebei Province(A201905006,China) Fund of National R&D Center for Edible Fungus Processing Technology,Henan University(20200109,China) 

主　　题：Antrodia cinnamomea UPLC-Q-TOF/MS Anti-hepatocellular carcinoma Network pharmacology PI3K/AKT Cell cycle 

摘      要：Antrodia cinnamomea is extensively used as a traditional medicine to prevention and treatment of liver ***,its comprehensive chemical fingerprint is uncertain,and the mechanisms,especially the potential therapeutic target for anti-hepatocellular carcinoma(HCC)are still *** UPLC-Q-TOF/MS,139 chemical components were identified in *** dropping pills(ACDPs).Based on these chemical components,network pharmacology demonstrated that the targets of active components were significantly enriched in the pathways in cancer,which were closely related with cell proliferation ***,HCC data was downloaded from Gene Expression Omnibus database(GEO).The Cancer Genome Atlas(TCGA)and Dis Ge NET were analyzed by bioinformatics,and 79 biomarkers were ***,nine targets of ACDP active components were revealed,and they were significantly enriched in PI3 K/AKT and cell cycle signaling *** affinity between these targets and their corresponding active ingredients was predicted by molecular ***,in vivo and in vitro experiments showed that ACDPs could reduce the activity of PI3 K/AKT signaling pathway and downregulate the expression of cell cycle-related proteins,contributing to the decreased growth of liver ***,PI3 K/AKT-cell cycle appears as the significant central node in anti-liver cancer of ***.