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m TOR cell signaling pathway contributes to the protective effects of ischemic postconditioning against stroke

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m TOR cell signaling pathway contributes to the protective e...

Perspectives on potential neuroprotective role of albumin in acute ischemic stroke

长三角地区神经科学论坛2016暨第八次会员代表大会

作者：谢嵘 Peng Wang Michelle Cheng Robert Sapolsky xunming ji Heng Zhao Department of Neurosurgery Huashan Hospital Fudan University Departments of Neurosurgery Stanford University Departments of Neurosurgery Stanford University Department of Neurosurgery Xuanwu Hospital Capital Medical School Departments of Biological Sciences Stanford University

＜正＞Introduction:Ischemic postconditioning（IPost C）provides protective effect against focal ischemia and improves neurological *** the m TOR pathway is protective or detrimental in brain injury induced by stroke is controversial,and whether it is involved in the protective effects of ischemic postconditioning against stroke has not been *** report that m TOR contributes to neuronal survival in vitro,in a neuronal culture,as well as in vivo,in stroke brains receiving IPostC.

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Journal of Translational Neuroscience 2023年第2期8卷 1-6页

作者： Yuanyuan Liu Xiao Dong Xuehong Chu Ran Meng Chuanhui Li Chen Zhou Chuanjie Wu xunming ji Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology and Stroke Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

Albumin is the most abundant protein in plasma and is synthesized primarily in the *** has a variety of biological roles,such as increasing colloid osmotic pressure, and performing antioxidant, anti-inflam-matory,and substance transportation *** studies have confirmed that albumin has neuroprotective effects and it has been used in the treatment of cerebral edema and increased intracranial *** this review we focus on the neuroprotective effects of albumin in ischemic stroke,such as the reduction of cerebral edema, antioxidant effects, protection of neuronal cell membranes, and increased cerebral blood flow. In addition, we summarize preclinical and clinical studies of albumin in ischemic stroke. We believe that the neuroprotective role of albumin should be re-investigated in the era of reperfusion therapy.

关键词： albumin acute ischemic stroke neuro-protection reperfusion therapy

Remote ischemic conditioning-induced hyperacute and acute responses of plasma proteome in healthy young male adults:a quantitative proteomic analysis

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Chinese Medical Journal 2023年第2期136卷 150-158页

作者： Siying Song Hao Wu Yunhuan Liu Duo Lan Baolian jiao Shuling Wan Yibing Guo Da Zhou Yuchuan Ding xunming ji Ran Meng Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Advanced Center of Stroke Beijing Institute for Brain DisordersBeijing 100053China Department of China-America Institute of Neuroscience Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology Huadong HospitalFudan UniversityShanghai 200031China Department of Neurosurgery Wayne State University School of MedicineDetroitMI 48201USA

Background: Long-term remote ischemic conditioning (RIC) has been proven to be beneficial in multiple diseases, such as cerebral and cardiovascular diseases. However, the hyperacute and acute effects of a single RIC stimulus are still not clear. Quantitative proteomic analyses of plasma proteins following RIC application have been conducted in preclinical and clinical studies but exhibit high heterogeneity in results due to wide variations in experimental setups and sampling procedures. Hence, this study aimed to explore the immediate effects of RIC on plasma proteome in healthy young adults to exclude confounding factors of disease entity, such as medications and gender. Methods: Young healthy male participants were enrolled after a systematic physical examination and 6-month lifestyle observation. Individual RIC sessions included five cycles of alternative ischemia and reperfusion, each lasting for 5 min in bilateral forearms. Blood samples were collected at baseline, 5 min after RIC, and 2 h after RIC, and then samples were processed for proteomic analysis using liquid chromatography-tandem mass spectrometry method. Results: Proteins related to lipid metabolism (e.g., Apolipoprotein F), coagulation factors (hepatocyte growth factor activator preproprotein), members of complement cascades (mannan-binding lectin serine protease 1 isoform 2 precursor), and inflammatory responses (carboxypeptidase N catalytic chain precursor) were differentially altered at their serum levels following the RIC intervention. The most enriched pathways were protein glycosylation and complement/coagulation cascades. Conclusions: One-time RIC stimulus may induce instant cellular responses like anti-inflammation, coagulation, and fibrinolysis balancing, and lipid metabolism regulation which are protective in different perspectives. Protective effects of single RIC in hyperacute and acute phases may be exploited in clinical emergency settings due to apparently beneficial alterations in plas

关键词： Healthy male adult Remote ischemic conditioning Quantitative proteomics analysis Beneficial effect

Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia

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Bioactive Materials 2023年第8期26卷 116-127页

作者： Ming Li Yuan Gao Miaowen jiang Hongkang Zhang Yang Zhang Yan Wu Wenhao Zhou Di Wu Chuanjie Wu Longfei Wu Luzi Bao Xiaoxiao Ge Zhengfei Qi Ming Wei Ang Li Yuchuan Ding jicheng Zhang Guangzhen Pan Yu Wu Yan Cheng Yufeng Zheng xunming ji China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing100053China School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing100191China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100069China School of Materials Science and Engineering Peking UniversityBeijing100871China Shaanxi Key Laboratory of Biomedical Metallic Materials Northwest Institute for Nonferrous Metal ResearchXi’an710016China Department of Biomedical Engineering Columbia UniversityNew York CityNY10027USA Department of Neurosurgery Wayne State University School of MedicineDetroitMI48201USA Gong Yi Van-research Innovation Composite Material Co.Ltd Zheng Zhou451299China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing100053China

Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection,but current catheters do not support thermally-insulated transfer of cold infusate,which results in an increased exit temperature,causes hemodilution,and limits its cooling ***,air-sprayed fibroin/silica-based coatings combined with chemical vapor deposited parylene-C capping film was prepared on *** coating features in dual-sized-hollow-microparticle incorporated structures with low thermal *** infusate exit temperature is tunable by adjusting the coating thickness and infusion *** peeling or cracking was observed on the coatings under bending and rotational scenarios in the vascular *** efficiency was verified in a swine model,and the outlet temperature of coated catheter(75μm thickness)was 1.8-2.0◦C lower than that of the uncoated *** pioneering work on catheter thermal insulation coatings may facilitate the clinical translation of selective endovascular hypothermia for neuroprotection in patients with acute ischemic stroke.

关键词： Silk fibroin Thermal insulation coating Catheter Stroke Hypothermia

降低颈动脉支架置入术后缺血性脑损伤措施的研究进展

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中国脑血管病杂志 2020年第5期17卷 266-271页

作者：蒋芳赵文博吉训明首都医科大学宣武医院神经内科北京100053 首都医科大学宣武医院神经外科北京100053

颈动脉支架置入术(CAS)后缺血性脑损伤是认知功能下降及临床缺血事件的有效预测指标。目前,降低CAS术后缺血性脑损伤发生的措施包括选择合适的患者、控制危险因素以及应用抗血小板聚集及他汀类降脂药、神经保护药物和非药物神经保护措... 详细信息

颈动脉支架置入术(CAS)后缺血性脑损伤是认知功能下降及临床缺血事件的有效预测指标。目前,降低CAS术后缺血性脑损伤发生的措施包括选择合适的患者、控制危险因素以及应用抗血小板聚集及他汀类降脂药、神经保护药物和非药物神经保护措施、根据患者情况个体化选择合适的支架类型及栓塞保护装置等,对术者进行规范化培训也是降低手术并发症的重要措施之一。尽管如此,CAS术后缺血性脑损伤的发生率仍较高。因此,作者将该类治疗措施进行综述,以期降低CAS并发症的发生率。

关键词：颈动脉狭窄支架颈动脉支架置入术缺血性脑损伤综述

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儿童颅内静脉窦血栓形成抗凝治疗的队列研究

中华小儿外科杂志 2016年第3期37卷 163-171页

作者：王澎吉训明冀园琦张建中国医学科学院阜外心血管病医院北京100037 首都医科大学宣武医院首都医科大学附属北京儿童医院

目的评估抗凝治疗是否可以改善患儿颅内静脉窦血栓形成（cerebral venous sinus thrombosis，CVST）的临床症状和长期生存质量。方法资料选取2006年6月至2013年6月收治的符合标准的CVST患儿58例（1个月～16岁）。其中，接受抗凝治疗（... 详细信息

目的评估抗凝治疗是否可以改善患儿颅内静脉窦血栓形成（cerebral venous sinus thrombosis，CVST）的临床症状和长期生存质量。方法资料选取2006年6月至2013年6月收治的符合标准的CVST患儿58例（1个月～16岁）。其中，接受抗凝治疗（低分子肝素、华法林、尿激酶）38例，为抗凝治疗组（抗凝组）；行非抗凝对症治疗20例，为非抗凝治疗组（非抗凝组）。回顾性分析评价两组血栓复发率、抗凝相关出血率及长期预后情况。长期生存质量应用改良Rankin评分进行评估。结果治疗后出现抗凝治疗相关出血2例（5．3％）。复发5例（8．6％）中，抗凝组1例，非抗凝组4例，组间比较，差异有统计学意义（P=0．023）。死亡5例（8．6％）中，抗凝组1例，非抗凝组4例，抗凝治疗同单纯对症治疗相比降低病死率25％～30％。长期随访45例（不包括死亡5例及失访8例）临床长期预后不良6例（13．3％），整体预后不良（包括死亡5例和长期预后不良6例）11例（22％）。影响长期预后因素中足月儿预后较好（风险比0．12，P=0．045）、颅内病灶广泛预后较差（风险比15．16，P=0．042）和抗凝治疗为主要减少预后不良发生率因素（风险比0．007，P=0．024）；起病初期颅高压发生的相关因素中，新生儿窒息史患儿颅高压发生率低（风险比0．35，P=0．025）、颅内病灶广泛发生率高（风险比8．73，P=0．048）和发病时间较短治疗及时的患儿发生颅高压率较低（风险比0．89，P=0．003）。同时，抗凝治疗对于亚急性期颅高压控制有一定帮助（P=0．048）。结论对于儿童CVST（包括轻度颅内出血的CVST患儿）抗凝治疗是安全有效的治疗方法，可有效降低其复发率，延长生存时间和改善长期生存质量。

关键词：颅静脉窦血栓形成对比研究

The effects of hypoxia on major blood components:a brief review

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Journal of Translational Neuroscience 2017年第2期2卷 31-36页

作者： Ming Li Yang Li Changhong Ren Hong An Fang jiang Feng Yan Sijie Li Di Wu Changqing Xia xunming ji Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Hematology Xuanwu HospitalCapital Medical UniversityBeijing 100053China China-America Institute of Neuroscience Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

The prevalence of stroke displays obvious geographical variation and is higher on ***,prolonged stay at high altitude is associated with higher incidence of ***-altitude hypoxia can elicit various physiological dysfunctions,and hypoxia is suggested to be the principal contributing factor of *** this brief review,the effects of hypoxia on the properties of the blood components such as erythrocytes,leukocytes and thrombocytes are presented,in an effort to inform the prevention and treatment of stroke in high-altitude areas.

关键词： hypoxia cerebral blood stroke high altitude

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从医学人文教育缺乏的角度看临床教师的责任

中国医院 2010年第6期14卷 76-77页

作者：吉训明首都医科大学宣武医院北京市宣武区长椿街45号100053

目的:提高临床教师对医学生人文素质培养的责任意识。方法:对医学生人文素质教育中存在的主、客观问题进行分析。结果:由于医学院校人文教育课程缺乏、医学生自身人文素质养成重视不够以及个别临床教师人文素质缺陷等原因,导致医患之间... 详细信息

目的:提高临床教师对医学生人文素质培养的责任意识。方法:对医学生人文素质教育中存在的主、客观问题进行分析。结果:由于医学院校人文教育课程缺乏、医学生自身人文素质养成重视不够以及个别临床教师人文素质缺陷等原因,导致医患之间有效沟通不利的情况时有发生。结论:加强医学生人文精神和人文能力培养,是临床教师的历史使命和责任,应当着力做好。

关键词：医学生人文教育临床教师责任

Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications

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Science China(Life Sciences) 2022年第7期65卷 1342-1356页

作者： Hui Zhao jianping Zhao Di Wu Zhaolin Sun Yang Hua Min Zheng Yumei Liu Qi Yang Xiahe Huang Yuan Li Yueshan Piao Yingchun Wang Sin Man Lam Huijuan Xu Guanghou Shui Yongjun Wang Haifeng Yao Liangxue Lai Zhuo Du jidong Mi Enqi Liu xunming ji Yong Q.Zhang Key Laboratory of Molecular Developmental Biology and CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute ofGenetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Beijing Sinogene Biotechnology Co.Ltd Beijing 102200China Xuanwu Hospital Capital Medical UniversityBeijing 100053China TianTan Hospital Capital Medical UniversityBeijing 100070China Beijing Petsguard Animal Hospital Beijing 100192China Laboratory Animal Center Xi’an Jiaotong University Health Science CenterXi’an 710049China

Atherosclerotic cardiovascular disease resulting from dysregulated lipid metabolism is the leading cause of morbidity and mortality *** E(ApoE)plays a critical role in cholesterol *** in lipid-metabolizing proteins including ApoE in multiple model organisms such as mice and rats exhibiting elevated levels of cholesterol have been widely used for dissecting the pathology of atherosclerosis,but few of these animal models exhibit advanced atherosclerotic plaques leading to ischemia-induced clinical symptoms,limiting their use for translational *** we report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries,together with clinical manifestations of stroke and gangrene,in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer ***,the hypercholesterolemia and atherosclerotic complications in F0 mutants are recapitulated in their *** the ApoE-associated atherosclerosis and clinical manifestations in mutant dogs are more similar to that in human patients compared with those in other animal models,these mutant dogs will be invaluable in developing and evaluating new therapies,including endovascular procedures,against atherosclerosis and related disorders.

关键词： ApoE atherosclerosis hypercholesterolemia gangrene stroke