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Single-cell RNA sequencing in juvenile idiopathic arthritis

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Genes & Diseases 2024年第2期11卷 633-644页

作者： xiwen Luo Xuemei Tang Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Child Infection and Immunity Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children,with onset before age 16 and lasting for more than 6 *** is a highly heterogeneous condition with various consequences for health and quality of *** some JIA patients,early detection and intervention remain *** a result,further investigation of the complex and unknown mechanisms underlying JIA is *** in technology now allow us to describe the biological heterogeneity and function of individual cell populations in *** this review,we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

关键词： Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte Single-cell RNA sequencing Synoviocyte T cell

Design of an on‑chip wavelength conversion device assisted by an erbium‑ytterbium co‑doped waveguide amplifier

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Frontiers of Optoelectronics 2024年第2期17卷 51-60页

作者： Chen Zhou xiwen He Mingyue Xiao Deyue Ma Weibiao Chen Zhiping Zhou School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Aerospace Laser Technology and System Department Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Hangzhou aijie Optoelectronic Technology Co.Ltd. Hangzhou 311400China

In current documented studies,it has been observed that wavelength converters utilizing AlGaAsOI waveguides exhibit suboptimal on-chip wavelength conversion efficiency from the C-band to the 2μm band,generally falling below−20.0 *** address this issue,we present a novel wavelength conversion device assisted by a waveguide amplifier,incorporating both AlGaAs wavelength converter and erbium-ytterbium co-doped waveguide amplifier,thereby achieving a notable conversion efficiency exceeding 0 *** noteworthy enhancement in efficiency can be attributed to the specific dispersion design of the AlGaAs wavelength converter,which enables an upsurge in conversion efficiency to−15.54 dB under 100 mW of pump ***,the integration of an erbium-ytterbium co-doped waveguide amplifier facilitates a loss compensation of over 15 *** the use of external optical amplifiers,this device enables efficient and high-bandwidth wavelength conversion,showing promising applications in various fields,such as optical communication,sensing,imaging,and beyond.

关键词： Silicon-based optoelectronics Wavelength conversion Waveguide amplifier 2μm band

Towards green asphalt materials with lower emission of volatile organic compounds: A review on the release characteristics and its emission reduction additives

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Journal of Road Engineering 2024年第3期4卷 292-317页

作者： xiwen Chang Feng Wang Rui Wu Chen Wang Yue Xiao State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Chang'an UniversityXi'an 710064China Faculty of Civil Engineering and Geosciences Delft University of TechnologyDelft 2628 CNthe Netherlands

Recently, researchers in the road field are focusing on the development of green asphalt materials with loweremission of volatile organic compounds (VOCs). The characterization methodology of asphalt VOCs and theinfluencing factors on VOCs release have always been the basic issue of asphalt VOCs emission reduction *** have proposed a variety of asphalt VOCs characterization methodologies, which also have mutuallyirreplaceable characteristics. Asphalt VOCs volatilization is affected by many factors. In this study, asphalt VOCscharacterization methodologies were summarized, including their advantages, disadvantages, characteristics andapplicable requirements. Subsequently, the influencing factors of VOCs release, such as asphalt types and environment conditions, are summarized to provide theoretical support for the emission reduction research. Theclassification and mechanism of newly-development asphalt VOCs emission reduction materials are reviewed. Thereduction efficiencies are also compared to select better materials and put forward the improvement objective ofnew materials and new processes. In addition, the prospects about development of VOCs release mechanism ofasphalt materials during the full life cycle and feasibility research of high-efficiency composite emission reductionmaterials in the future were put forward.

关键词： Asphalt VOCs Volatile organic compounds Green asphalt materials Reduction efficiency Hazardous emission

Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells

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Chinese Chemical Letters 2024年第9期35卷 219-222页

作者： Yan Liu Yang Wang Jiayi Zhu Xuxian Su Xudong Lin Liang Xu xiwen Xing Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275China Department of Cardiology the first people’s hospital of FoshanFoshan 528000China Department of Biotechnology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

The clustered regularly interspersed short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)system is an RNA-guided platform for highly efficient and specific genome targeting in diverse organisms,which has been exploited for various applications in gene *** with the constantly active CRISPR/Cas9 function,conditional control of its activity can improve the performance of the system with reduced side effects and high spatiotemporal *** pH-responsive triplex RNA was successful used in CRISPR-derived RNA/trans-activating crRNA(crRNA/tracrRNA)of CRISPR/Cas9,thus affecting RNA/dead Cas9(dCas9)complex to target DNA in vitro and in *** design of triplex RNA opens a new window towards the broad involvement of eukaryotic cells for conditional control of CRISPR/Cas9function.?2024 Published by Elsevier *** behalf of Chinese Chemical Society and Institute of Materia Medica,Chinese Academy of Medical Sciences.

关键词： RNA triplex pH-responsive CRISPR/Cas9 Gene manipulation Eukaryotic cells

Whole-genome sequencing in medicinal plants:current progress and prospect

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Science China(Life Sciences) 2024年第2期67卷 258-273页

作者： Yifei Pei Liang Leng Wei Sun Baocai Liu Xue Feng xiwen Li Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Agricultural Bioresource Fujian Academy of Agricultural SciencesFuzhou 350003China

Advancements in genomics have dramatically accelerated the research on medicinal plants,and the development of herbgenomics has promoted the“Project of 1K Medicinal Plant Genome”to decipher their genetic ***,it is difficult to obtain their high-quality whole genomes because of the prevalence of polyploidy and/or high genomic *** genomes of 123 medicinal plants were published until September *** published genome sequences were investigated in this review,covering their classification,research teams,ploidy,medicinal functions,and sequencing *** than 1,000 institutes or universities around the world and 50 countries are conducting research on medicinal plant *** species account for a majority of sequenced medicinal *** whole genomes of plants in the Poaceae family are the most *** 40%of the published papers studied species with tonifying,replenishing,and heat-cleaning medicinal *** plants are still in the process of domestication as compared with crops,thereby resulting in unclear genetic backgrounds and the lack of pure lines,thus making their genomes more difficult to *** addition,there is still no clear routine framework for a medicinal plant to obtain a high-quality whole ***,a clear and complete strategy has been originally proposed for creating a high-quality whole genome of medicinal ***,whole genome-based biological studies of medicinal plants,including breeding and biosynthesis,were *** also advocate that a research platform of model medicinal plants should be established to promote the genomics research of medicinal plants.

关键词： herbgenomics whole genome high throughput sequencing research strategy model species application

Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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Neural Regeneration Research 2024年第9期19卷 1890-1898页

作者： Qiuqin Han Wenhui Li Peiqing Chen Lijuan Wang xiwen Bao Renyan Huang Guobin Liu Xiaorong Chen Department of Scientific Research Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Traditional Chinese Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Physiology Laboratory of Neurodegenerative DiseasesChangzhi Medical CollegeChangzhiShanxi ProvinceChina

Previous studies have demonstrated a bidirectional relationship between inflammation and *** of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological *** patients with major depressive disorder,NLRP3 inflammasome levels are significantly *** the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic *** this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 ***,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating ***,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to ***,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression *** modulation of NLRP3 inflammasomes in microglia holds promise for the management of *** investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

关键词： depression microglia neuroinflammation NLRP3 inflammasome

Novel Optimal Dispatch Method for Multiple Energy Sources in Regional Integrated Energy Systems Considering Wind Curtailment

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2166-2173页

作者： Yang Gao Qian ai Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China

Power-to-gas technology uses temporary surplus electricity to create either renewable hydrogen or renewable natural gas,which can then be stored in natural-gas pipelines and used when *** a result,P2G transforms conventional one-way coupling of a power/heat/natural-gas system into twoway ***,its operating characteristics makes it possible to more effectively utilize *** paper describes a new optimal dispatch model for integrated electricity/gas/heat energy *** model considers the effective use of surplus wind-energy with electricity-to-gas ***,a multi-energy network model is built,taking into account both equipment and network ***,we apply a novel two-layer optimization method,which uses P2G,to“absorb”wind *** the top-layer model is used for the dayahead dispatch of the natural-gas network containing P2G,the bottom-layer model describes the day-ahead economic dispatch of the electricity/heat system,which includes wind *** on the Karush-Kuhn-Tucher conditions of the bottom-layer model,the two-layer model is transformed into a single-layer model,and we linearize the nonlinear equation to convert the nonlinear model into a mix-integer linear programming problem,which is solvable using the General Algebraic Modeling ***,numerical case-studies are performed to evaluate the accuracy and effectiveness of the proposed method.

关键词： Multi-enery coupling power-to-gas two-layer optimization wind-power consumption

Nanophase separated,grafted alternate copolymer styrene-maleic anhydride as an efficient room temperature solid state lithium ion conductor

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Chinese Chemical Letters 2024年第7期35卷 491-496页

作者： Qian Wang Ting Gao xiwen Lu Hangchao Wang Minggui Xu Longtao Ren Zheng Chang Wen Liu Institute of Science and Technology China Three Gorges CorporationBeijing 100038China State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029China

All solid-state lithium metal batteries(ASSLMBs)based on polymer solid electrolyte and lithium metal anode have attracted much attention due to their high energy density and intrinsic ***,the low ionic conductivity at room temperature and poor mechanical properties of the solid polymer electrolyte result in increased polarization and poor cycling stability of the Li metal *** order to improve the ionic conductivity at room temperature while maintaining mechanical strength,we combine the conductivity of short chain polyethylene oxide(PEO)and strength of styrene-maleic anhydride copolymer(SMA)to obtain a grafted block copolymer with nanophase separation structure,which has room temperature ionic conductivity up to 1.14×10^(-4)S/cm and tensile strength up to 1.4 ***||Li symmetric cell can work stably for more than 1500 h under the condition of 0.1 mA/cm^(2).Li||LiFePO_(4)full cells can deliver a high capacity of 151.4 mAh/g at 25℃and 0.2 C/0.2 C charge/discharge conditions,showing 85.6%capacity retention after 400 ***,the all solid state Li||LiFePO_(4)pouch cell shows excellent safety performance under different abuse *** results demonstrate that the nanophase separated,grafted alternate copolymer electrolyte has huge potential for application in Li metal batteries.

关键词： Solid polymer electrolyte All solid-state battery Li metal battery Copolymers Nanophase separation

Molecular quantification of herbs(Herb-Q):a pyrosequencingbased approach and its application in Pinellia ternata

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Chinese Journal of Natural Medicines 2024年第7期22卷 663-672页

作者： PEI Yifei LIU Ziyi YU Dade ZHANG Xiangyu SUN Wei CHEN Xiaofang FENG Xue LI xiwen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Bijie Institute of Traditional Chinese Medicine Bijie 551700China The Key Laboratory for Health Industry of Bijie Bijie Medical CollegeBijie 551700China

Variations in herb dosage due to species adulteration and dosing inaccuracies can substantially affect clinical safety and *** species quantification remains challenging,as current methods often yield inconsistent *** study introduces a novel pyrosequencing-based technique,termed herb molecular quantification(Herb-Q),designed to precisely quantify herbal *** evaluated its effectiveness using Pinellia ternata and five of its ***,we assessed commonly used DNA barcodes with sequences from a public database,identifying two candidate regions,Maturase K(matK)and internal transcribed spacer 2(ITS2),for screening specific single nucleotide polymorphism(SNP)loci,allowing for species-specific *** loci were validated by amplifying and sequencing genomic material from collected *** validation studies showed that Herb-Q demonstrated excellent linearity,accuracy,repeatability,and detection *** established quantitative standard curves with high R^(2)values(>0.99)to enable precise species quantification,which were combined with external standards to provide clear and accurate visual quantification *** average bias in quantifying the tuber of *** was 2.38%,confirming that Herb-Q can accurately identify and quantify herbal product ***,the entire quantification process took less than 4 *** study presents a novel,rapid method for accurately quantifying species in herbal products and advances the application of DNA barcoding from species identification to quantitative detection.

关键词： Quantification Adulterant DNA barcodes Single nucleotide polymorphism