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几种体温计测量体温和测温速度的比较

北京生物医学工程 2011年第6期30卷 624-627页

作者：王薇薇郭鑫媛杨琳王杨柳张蕾张松杨益民北京工业大学生命科学与生物工程学院北京100124

目的目前市场上体温计的种类很多,但各类体温计测量的体温和测温速度不尽相同。本文通过温度试验对五种不同原理和不同品牌的体温计测量的体温和测量速度进行了对比研究。方法以水银体温计为温度测量的标准,使用额温体温计、耳温体温计... 详细信息

目的目前市场上体温计的种类很多,但各类体温计测量的体温和测温速度不尽相同。本文通过温度试验对五种不同原理和不同品牌的体温计测量的体温和测量速度进行了对比研究。方法以水银体温计为温度测量的标准,使用额温体温计、耳温体温计、电子体温计和伟伦体温计分别测量受试者体温,对四种体温计测量的体温和测温速度进行对比分析。结果伟伦体温计测量的腋温与水银体温计测量腋温没有统计学差异;电子体温计测量的腋温、额温测温计测量的额温和耳温测温计测量的耳温与水银体温计测量的腋温相比有统计学差异。耳温体温计测量耳温的时间最短,但有4 s的复位时间,且易因操作不当产生误差;额温体温计在4 s左右温度会达到稳定;电子体温计测温时间最长,连续使用时需要3 s复位;伟伦体温计测量口腔温度较快,但连续测量时脱去和再次取用口套约需3 s,伟伦体温计测量腋温时间相对其它腋温测量方式最短。结论耳温体温计与额温体温计测量温度方便、快速,能够满足快速体温测量场合的需要,但其测量的额温或耳温与水银体温计测量的腋温有一定差异;伟伦体温计和电子体温计测量的腋温与水银体温计测量的腋温相比,伟伦体温计更为快速、准确。

关键词：体温计体温测量速度

Yushu earthquake synergic analysis using multimodal SAR datasets

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Chinese Science Bulletin 2010年第31期55卷 3499-3503页

作者： guo HuaDong WANG xinyuan LI XinWu LIU Guang ZHANG Lu YAN ShiYong Key Laboratory of Digital Earth Center for Earth Observation and Digital Earth Chinese Academy of Sciences Beijing 100190 China

The large earthquake measuring 7.1 on the Richter scale that occurred in Yushu County,Qinghai Province,China,on April 14,2010,caused a huge loss of life and major damage to people's *** three modal synthetic-aperture radar(SAR) datasets,wide-swath SAR,interferometric SAR and polarimetric SAR,the following studies were conducted:(1) From Radarsat-2 wide swath SAR data,the regional geological structures and lithologic distribution characteristics of the Yushu earthquake were analyzed.(2) Using advanced land observing satellite/phased array L-band interferometric SAR data,the coseismic deformation field of the Yushu earthquake was obtained,and the size and spatial distribution of deformation were studied combining with the result of regional geological background analysis.(3) From Radarsat-2 polarimetric SAR data,the H-α-ρ method was used to extract the spatial distribution of building collapse caused by the earthquake in the Yushu urban area,and the reasons for the severe earthquake damage to buildings are also discussed and *** study results demonstrate the effectiveness and important potential of using multimodal SAR data for synergic analysis and assessment of earthquake disasters.

关键词：地震台网协同分析玉树县数据集多式联运特区合成孔径雷达区域地质构造

基于TREM2的抗阿尔茨海默病和缺血性脑卒中药物的药理作用研究进展

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药物评价研究 2024年第1期47卷 191-196页

作者：许海英曹玉爽袁庆杜鑫苑郭莉琛梁冰张彤孙锦胡利民天津中医药大学中医药研究院天津301617 天津中医药大学组分中药国家重点实验室天津301617 天津中医药大学中药方剂药理学教育部重点实验室天津301617

缺血性脑卒中(IS)和阿尔茨海默病(AD)具有共同的病理特征,如β-淀粉样蛋白沉积、血管病变、氧化应激和神经炎症等,均会导致认知能力下降。髓样细胞触发受体2(TREM2)作为免疫相关受体,可以通过调节小胶质细胞的表型和功能来协调神经炎症... 详细信息

缺血性脑卒中(IS)和阿尔茨海默病(AD)具有共同的病理特征,如β-淀粉样蛋白沉积、血管病变、氧化应激和神经炎症等,均会导致认知能力下降。髓样细胞触发受体2(TREM2)作为免疫相关受体,可以通过调节小胶质细胞的表型和功能来协调神经炎症,参与AD和IS的进程。蛇床子素、补脾醒神益智方、AL002、褪黑激素、羟基红花黄色素A等靶向TREM2免疫受体,对AD和IS等神经退行性疾病有疗效。就TREM2在AD和IS中的重要作用和以TREM2为靶点治疗AD和IS的相关药物进行综述,以期为退行性疾病、脑血管疾病等相关治疗药物的研发提供新思路。

关键词：缺血性脑卒中阿尔茨海默病髓样细胞触发受体2(TREM2) 靶向TREM2药物蛇床子素羟基红花黄色素A

餐厨垃圾废水制备液态固氮菌肥的培养特性研究

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绿色科技 2018年第8期20卷 103-106页

作者：王永京林昌源任连海杨振兵李学伟郭新愿北京工商大学北京100048

利用餐厨垃圾废水进行液态固氮菌肥制备,以圆褐固氮菌为实验菌种,考察餐厨垃圾在不同湿热预处理条件下,固氮菌在餐厨垃圾废水中的生长情况及废水水质变化规律。研究发现,湿热预处理对固氮菌的生长具有显著的促进作用。在固氮菌的培养过... 详细信息

利用餐厨垃圾废水进行液态固氮菌肥制备,以圆褐固氮菌为实验菌种,考察餐厨垃圾在不同湿热预处理条件下,固氮菌在餐厨垃圾废水中的生长情况及废水水质变化规律。研究发现,湿热预处理对固氮菌的生长具有显著的促进作用。在固氮菌的培养过程中,餐厨垃圾废水中SCOD和还原糖的去除率分别从71.8%和56.1%提高到74.5%~84.9%和63.6%~79.5%,表明湿热处理能够促进固氮菌对SCOD、还原糖的利用效果。在培养过程中,氨氮先有所升高后有降低趋势,pH值先降低,而后随着培养时间的延长有所升高,基本维持在5.71~6.06之间。

关键词：餐厨垃圾废水湿热处理圆褐固氮菌液态菌肥

PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop

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Cancer Communications 2022年第10期42卷 987-1007页

作者： xinyuan Zhao Dalong Shu Wenjuan Sun Shanshan Si Wei Ran Bing guo Li Cui Department of Endodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280P.R.China Department of Oral and Maxillofacial Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Department of Stomatology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510630P.R.China Department of Oral Emergency Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280P.R.China Department of Dentistry The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Department of Oral and Maxillofacial Surgery Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280P.R.China Division of Oral Biology and Medicine School of DentistryUniversity of CaliforniaLos AngelesLos AngelesCalifornia 90095United States

Background:Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent malignancies worldwide and is characterized by unfavorable prognosis,high lymph node metastasis and early ***,the molecular events regulating HNSCC tumorigenesis remain poorly ***,uncovering the underlying mechanisms is urgently needed to identify novel and promising therapeutic targets for *** this study,we aimed to explore the role of pleckstrin-2(PLEK2)in regulating HNSCC ***:The expression pattern of PLEK2 and its clinical significance in HNSCC were determined by analyzing publicly assessable datasets and our own independent HNSCC *** vitro and in vivo experiments,including cell proliferation,colony formation,Matrigel invasion,tumor sphere formation,ALDEFLUOR,Western blotting assays and xenograft mouse models,were used to investigate the role of PLEK2 in regulating the malignant behaviors of HNSCC *** underlying molecular mechanisms for the tumor-promoting role of PLEK2 were elucidated using co-immunoprecipitation,cycloheximide chase analysis,ubiquitination assays,chromatin immunoprecipitation-quantitative polymerase chain reaction,luciferase reporter assays and rescue ***:The expression levels of PLEK2 mRNA and protein were significantly increased in HNSCC tissues,and PLEK2 overexpression was strongly associated with poor overall survival and therapeutic ***,PLEK2 was important for maintaining the proliferation,invasion,epithelial-mesenchymal transition,cancer stemness and tumorigenesis of HNSCC cells and could alter the cellular metabolism of the cancer ***,PLEK2 interacted with c-Myc and reduced the association of F-box and WD repeat domain containing 7(FBXW7)with c-Myc,thereby avoiding ubiquitination and subsequent proteasome-mediated degradation of ***,the c-Myc signaling activated by PLEK2 was important for sustaining the aggressive malignant

关键词： c-Myc cancer stemness FBXW7 HNSCC PLEK2 positive feedback loop tumorigenesis ubiquitination-mediated degradation

腰椎手法配合电针治疗急性非特异性下腰痛临床观察

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中国中医急症 2024年第8期33卷 1402-1405页

作者：郭耀斌张宇占茂林吕子萌邓新源安徽中医药大学第一附属医院安徽合肥230031 安徽中医药大学安徽合肥230038

目的评价基于“筋骨并举”思想指导的腰椎手法配合电针治疗急性非特异性下腰痛的疗效。方法68例患者随机分为两组各34例。观察组采用腰椎手法配合电针治疗,对照组单纯采用电针治疗。治疗前和治疗2周后评价疼痛视觉模拟量表(VAS)评分、... 详细信息

目的评价基于“筋骨并举”思想指导的腰椎手法配合电针治疗急性非特异性下腰痛的疗效。方法68例患者随机分为两组各34例。观察组采用腰椎手法配合电针治疗,对照组单纯采用电针治疗。治疗前和治疗2周后评价疼痛视觉模拟量表(VAS)评分、日本骨科协会评分量表(JOABPEQ)、Oswestry功能障碍指数(ODI)评分、指地距离(FFD)、Schober试验距离。结果治疗后,两组患者VAS、JOABPEQ、ODI的评分及FFD、Schober试验距离均较治疗前改善(P<0.05),且观察组各项评分更优(P<0.05)。结论基于“筋骨并举”思想指导的腰椎手法配合电针治疗能更加有效地治疗急性非特异性下腰痛,值得推广。

关键词：非特异性下腰痛筋骨并举腰椎手法电针

A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

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Chemical Research in Chinese Universities 2021年第4期37卷 906-913页

作者： REN Yiqing LIU Xinlong GE Huan guo Yuanyuan ZHANG Qiushuang XIE Miao WANG Ping ZHU xinyuan ZHANG Chuan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai200240P.R.China Weigao Research Center Shanghai201203P.R.China

A combinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA)*** this approach,siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid *** to small rigid siRNA duplex,the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester),resulting in the formation of a novel platform for efficient siRNA delivery.

关键词： Nucleic acid nanogel Electrostatic compression siRNA delivery Self-assembly

Imperfection sensitivity of mechanical properties in soft network materials with horseshoe microstructures

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Acta Mechanica Sinica 2021年第7期37卷 1050-1062,I0001页

作者： Jianxing Liu xinyuan Zhu Zhangming Shen Yihui Zhang AML Department of Engineering MechanicsCenter for Flexible Electronics TechnologyTsinghua UniversityBeijing 100084China

Developments of soft network materials with rationally distributed wavy microstructures have enabled many promising applications in bio-integrated electronic devices,due to their abilities to reproduce precisely nonlinear mechanical properties of human tissues/*** practical applications,the soft network materials usually serve as the encapsulation layer and/or substrate of bio-integrated electronic devices,where deterministic holes can be utilized to accommodate hard chips,thereby increasing the filling ratio of the device ***,it is essential to understand how the hole-type imperfection affects the stretchability of soft network materialswith various geometric *** presents a systematic investigation of the imperfection sensitivity of mechanical properties in soft network materials consisting of horseshoe microstructures,through combined computational and experimental studies.A factor of imperfection insensitivity of stretchability is introduced to quantify the influence of hole imperfections,as compared to the case of perfect soft network *** factor is shown to have different dependences on the arc angle and normalized width of horseshoe microstructures for triangular network *** soft triangular and Kagome network materials,especially with the arc angle in the range of(30?,60?),are found to be much more imperfection insensitive than corresponding traditional lattice materials with straight ***,the soft honeycomb network materials are not as imperfection insensitive as traditional honeycomb lattice materials.

关键词： Imperfect network material Imperfection insensitivity Microstructure shape Lattice topology Stretchability

改良根治术后pT_(1-2)N_(1)期乳腺癌的局部区域复发部位——12个中心5442例患者的联合分析

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中华放射肿瘤学杂志 2022年第3期31卷 248-252页

作者：郭新园张玉晶张娜唐玉赵旭冉景灏房辉温戈程晶石梅郭启帅吴洪芬王小虎马常英李晔雄王宏梅刘敏王淑莲国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 中山大学附属第一医院放疗科广州510080 辽宁省肿瘤医院放疗科沈阳110042 广州医科大学附属第三医院肿瘤放疗科广州510150 华中科技大学同济医学院附属同济医院肿瘤科武汉430030 西京医院放疗科西安710032 重庆大学附属肿瘤医院/重庆市肿瘤医院放疗科重庆400030 吉林省肿瘤医院放疗科长春130012 甘肃省肿瘤医院/甘肃省医学科学研究院放疗科兰州730050 齐齐哈尔市第一医院放疗科齐齐哈尔161005 南方医科大学第一临床医院/南方医院放疗科广州510515 吉林大学白求恩第一医院放疗科长春130061

目的分析改良根治术后pT_(1-2)N_(1)期乳腺癌患者的局部区域复发(LRR)部位及放疗对复发的影响。方法收集中国12家医院符合条件的5442例乳腺癌患者资料,分析放疗和未放疗患者的LRR部位及不同部位放疗对复发的影响。采用Kaplan-Meier法计... 详细信息

目的分析改良根治术后pT_(1-2)N_(1)期乳腺癌患者的局部区域复发(LRR)部位及放疗对复发的影响。方法收集中国12家医院符合条件的5442例乳腺癌患者资料,分析放疗和未放疗患者的LRR部位及不同部位放疗对复发的影响。采用Kaplan-Meier法计算LRR率并log-rank法检验。结果全组中位随访63.8个月,395例患者出现LRR。无论辅助放疗与否和不同分子分型,胸壁和锁骨上区均为最常见的LRR部位。全组胸壁照射和未照射患者的5年胸壁复发率分别为2.5%和3.8%(P=0.003);锁骨上区照射和未照射患者的5年锁骨上淋巴结复发率分别为1.3%和4.1%(P<0.001);腋窝照射和未照射患者的5年无腋窝复发率分别为0.8%和1.5%(HR=0.31,95%CI为0.04~2.23,P=0.219);内乳照射和未照射患者的5年无内乳复发率分别为0.8%和1.5%(HR=0.45,95%CI为0.11~1.90,P=0.268)。结论改良根治术后pT_(1-2)N_(1)期乳腺癌患者的主要LRR部位是胸壁和锁骨上区,不受辅助放疗与否和分子分型的影响。胸壁和锁骨上区放疗显著降低相应部位的复发风险,而腋窝和内乳放疗未降低相应部位的复发风险。

关键词：乳腺肿瘤/改良根治术乳腺肿瘤/术后放疗局部区域复发阳性淋巴结