A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

作     者：REN Yiqing LIU Xinlong GE Huan GUO Yuanyuan ZHANG Qiushuang XIE Miao WANG Ping ZHU Xinyuan ZHANG Chuan REN Yiqing;LIU Xinlong;GE Huan;GUO Yuanyuan;ZHANG Qiushuang;XIE Miao;WANG Ping;ZHU Xinyuan;ZHANG Chuan

作者机构：School of Chemistry and Chemical EngineeringFrontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai200240P.R.China Weigao Research CenterShanghai201203P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2021年第37卷第4期

页      面：906-913页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：This work was supported by the National Key Research and Development Program of China(Nos.2018YFC1106102,2018YFA0902600) the National Natural Science Foundation of China(Nos.51973112,51690151,81871329) the Science Foundation of the Shanghai Municipal Science and Technology Commission,China(Nos.18JC1410800,19JC1410300) the Project of the Shanghai Outstanding Technology Leader,China(No.19XD1431900) 

主　　题：Nucleic acid nanogel Electrostatic compression siRNA delivery Self-assembly 

摘      要：A combinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering ribonucleic acid(siRNA)*** this approach,siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid *** to small rigid siRNA duplex,the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester),resulting in the formation of a novel platform for efficient siRNA delivery.