检索结果-南通市图书馆

Biomedical and Environmental Sciences 2024年第7期37卷 739-753页

作者： Keyuan Xu Xiaoting Tang Yun Xiang Yiding shen Zhennan Deng Pingping Ma xinkun shen Department of Orthopaedics The Third Affiliated Hospital of Wenzhou Medical University(Ruian People’s Hospital)Wenzhou 325016ZhejiangChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325027ZhejiangChina

Objective A high sodium(HS)diet is believed to affect bone metabolism *** its impact on osseointegration of titanium(Ti)implants holds significant implications for postoperative dietary management of implanted *** This investigation probed the impact of sodium ions(Na^(+))on neovascularization and osteogenesis around Ti implants in vivo,utilizing micro-computed tomography,hematoxylin and eosin staining,and immunohistochemical ***,in vitro experiments assessed the effects of varied Na^(+)concentrations and exposure durations on human umbilical vein endothelial cells(HUVECs)and MC3T3-E1 *** In vivo,increased dietary sodium(0.8%-6.0%)led to a substantial decline in CD34 positive HUVECs and new bone formation around Ti implants,alongside an increase in inflammatory *** vitro,an increase in Na^(+)concentration(140-150 mmol/L)adversely affected the proliferation,angiogenesis,and migration of HUVECs,especially with prolonged *** MC3T3-E1 cells initially exhibited less susceptibility to high Na^(+)concentrations compared to HUVECs during short-term exposure,prolonged exposure to a HS environment progressively diminished their proliferation,differentiation,and osteogenic *** These findings suggest that HS diet had a negative effect on the early osseointegration of Ti implants by interfering with the process of postoperative vascularized bone regeneration.

关键词： High-sodium Implants Vascularization Osseointegration

Phenylboronic acid-modified hollow silica nanoparticles for dual-responsive delivery of doxorubicin for targeted tumor therapy

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2017年第2期4卷 111-124页

作者： Ling Huang Qingfeng Zhang Liangliang Dai xinkun shen Weizhen Chen Kaiyong Cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044P.R.China

This work reports a multifunctional nanocarrier based on hollow mesoporous silica nanoparticles(HMSNs)for targeting tumor ***(DOX)was loaded into HMSNs and blocked with cytochrome C conjugated lactobionic acid(CytC–LA)via redox-cleavable disulfide bonds and pH-disassociation boronate ester bonds as intermediate *** CytC–LA was used both as sealing agent and targeting motif.A series of characterizations demonstrated the successful construction of the drug delivery *** system demonstrated pH and redox dual-responsive drug release behavior in *** DOX loading HMSNs system displayed a good biocompatibility,which could be specifically endocytosed by HepG2 cells and led to high cytotoxicity against tumor cells by inducing cell *** vivo data(tumor volume,tumor weight,terminal deoxynucleotidyl transferase dUTP nick end labeling and hematoxylin and eosin staining)proved that the system could deliver DOX to tumor site with high efficiency and inhibit tumor growth with minimal toxic side effect.

关键词： hollow mesoporous silica nanoparticles dual-response drug delivery targeted tumor therapy in vivo

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第4期7卷 405-419页

作者： xinkun shen Kai Fang Kendrick Hii Ru Yie Zixin Zhou Yiding shen Shuyi Wu Yue Zhu Zhennan Deng Pingping Ma Jianfeng Ma Jinsong Liu School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou325027China

The excessive accumulation of reactive oxygen species(ROS)under osteoporosis precipitates a microenvironment with high levels of oxidative stress(OS).This could significantly interfere with the bioactivity of conventional titanium implants,impeding their early osseointegration with *** have prepared a series of strontium(Sr)-doped titanium implants via micro-arc oxidation(MAO)to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic(high OS levels)*** from the chemical composition,all groups exhibited similar physicochemical properties(morphology,roughness,crystal structure,and wettability).Among the groups,the low Sr group(Sr25%)was more conducive to osteogenesis under normal *** contrast,by increasing the catalase(CAT)/superoxide dismutase(SOD)activity and decreasing ROS levels,the high Sr-doped samples(Sr75% and Sr100%)were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells,thus enhancing early ***,the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples(especially Sr100%)had positive effects on osteoimmunomodulation under the OS ***,the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations.

关键词： Osteoporosis Oxidative stress Strontium Osteoimmunomodulation Osteogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

西方专业社会工作的宗教渊源

东莞理工学院学报 2019年第4期26卷 93-97,102页

作者：沈新坤韶关学院法学院

西方专业社会工作最早源于基督教慈善活动,而基督教慈善活动源于人道慈善活动。不过,基督教对人性善进行了改造与完善,在这个过程中,基督教义下的助人实践逐渐实现了从神圣化向世俗化的转变。由于世俗化宗教助人实践涉及信仰问题,因此... 详细信息

西方专业社会工作最早源于基督教慈善活动,而基督教慈善活动源于人道慈善活动。不过,基督教对人性善进行了改造与完善,在这个过程中,基督教义下的助人实践逐渐实现了从神圣化向世俗化的转变。由于世俗化宗教助人实践涉及信仰问题,因此很难对其救助行为进行定性,即是利己还是利他,而且使得救助双方主客体身份模糊化。进一步而言,不仅基督教的神圣教义对专业社会工作价值理念起到至关重要的作用,而且基督教的慈善实践也直接推动了专业社会工作的三大方法,即个案法、小组法和社区法的形成。

关键词：社会工作专业社会工作宗教基督教

在线全文

学校读者我要写书评

暂无评论

农民工外出和返乡:村落文化的解构与重构

兰州学刊 2010年第3期 106-109页

作者：沈新坤习强南昌大学社会学系江西南昌330031 华中师范大学社会学院湖北武汉430079

改革开放以来,农民大规模地外出务工,导致传统村落结构逐步解体和传统村落文化继替逻辑的断裂。与此同时,农民工周期性返乡,特别是金融危机可能导致永久性返乡,在带来村落文化复兴的同时,促进了村落文化的重构。

关键词：村落文化农民工返乡潮文化变迁后返乡时代

Overview of machine learning applications in fusion plasma experiments on J-TEXT tokamak

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2022年第12期24卷 27-38页

作者： Wei ZHENG Fengming XUE Chengshuo shen Yu ZHONG xinkun AI Zhongyong CHEN Yonghua DING Ming ZHANG Zhoujun YANG Nengchao WANG Zhichao ZHANG Jiaolong DONG Chouyao TANG Yuan PAN International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People's Republic of China Institute of Artificial Intelligence Huazhong University of Science and TechnologyWuhan 430074People's Republic of China

Machine learning research and applications in fusion plasma experiments are one of the main subjects on *** 2013,various kinds of traditional machine learning,as well as deep learning methods have been applied to fusion plasma *** applications in the real-time experimental environment have proved the feasibility and effectiveness of the *** disruption prediction,we started by predicting disruptions of limited classes with a short warning time that could not meet the requirements of the mitigation *** years of study,nowadays disruption prediction methods on J-TEXT are able to predict all kinds of disruptions with a high success rate and long enough warning ***,cross-device disruption prediction methods have obtained promising *** analysis of the models are *** diagnostics data processing,efforts have been made to reduce manual work in processing and to increase the robustness of the diagnostic *** based on both traditional machine learning and deep learning have been applied to real-time experimental *** models have been cooperating with the plasma control system and other systems,to make joint decisions to further support the experiments.

关键词： machine learning disruption prediction diagnostics data processing J-TEXT

铌微合金化对调质型9NiCrMo钢强韧性的影响

在线全文

学校读者我要写书评

暂无评论

金属热处理 2016年第2期41卷 7-10页

作者：李珊珊沈俊昶朱心昆苏航昆明理工大学材料科学与工程学院云南昆明650093 钢铁研究总院工程用钢所北京100081

运用光学(OM)、扫描(SEM)和透射(TEM)电镜等方法,研究了不同回火温度下含Nb和不含Nb的9NiCrMo钢的力学性能,并对其微观组织结构进行了观察与分析。结果表明,无论有未添加Nb,试验钢具都有获得良好强韧性匹配的最佳回火温度,本试验中此温... 详细信息

运用光学(OM)、扫描(SEM)和透射(TEM)电镜等方法,研究了不同回火温度下含Nb和不含Nb的9NiCrMo钢的力学性能,并对其微观组织结构进行了观察与分析。结果表明,无论有未添加Nb,试验钢具都有获得良好强韧性匹配的最佳回火温度,本试验中此温度为590℃。添加Nb的9NiCrMo钢的强度无明显提高,却明显改善低温韧性。这是由于钢中添加Nb后,原奥氏体晶粒和组织都得到了细化。

关键词： 9NiCrMo钢回火强度低温韧性 Nb微合金化

在线全文

学校读者我要写书评

暂无评论

离子液体法制备再生细菌纤维素纤维

合成纤维工业 2011年第6期34卷 6-10页

作者：卢新坤沈新元王哲惟东华大学材料科学与工程学院纤维材料改性国家重点实验室上海201600

以离子液体(氯化1-甲基-3-正丁基咪唑)溶解高聚合度细菌纤维素(BC),采用湿法纺丝制备再生细菌纤维素(RBC)初生纤维;通过红外光谱分析(FTIR)、广角X射线衍射(WAXD)分析、热失重(TG)分析、扫描电镜(SEM)、单丝强度拉伸等表征了RBC初生纤... 详细信息

以离子液体(氯化1-甲基-3-正丁基咪唑)溶解高聚合度细菌纤维素(BC),采用湿法纺丝制备再生细菌纤维素(RBC)初生纤维;通过红外光谱分析(FTIR)、广角X射线衍射(WAXD)分析、热失重(TG)分析、扫描电镜(SEM)、单丝强度拉伸等表征了RBC初生纤维的结构和性能。结果表明:该溶剂体系通过10 h的快速搅拌溶解即可完全溶解BC,其溶解过程以物理变化为主,无衍生物生成;RBC初生纤维的晶型由纤维素Ⅰ型转变为纤维素Ⅱ型,结晶度明显下降,其断裂强度为0.54～1.36 cN/dtex,并随着凝固浴温度的降低而增强,在凝固浴中加入适量的无水乙醇有利于纤维强度的提高;RBC初生纤维的热稳定性相对于BC略有下降;RBC初生纤维表面粗糙、沟槽纵横,且初生纤维的皮层较薄,其芯层结构较为致密,存在少量微孔。

关键词：细菌纤维素离子液体再生细菌纤维素初生纤维

时效温度对785MPa级高强度含铜钢组织与性能的影响

在线全文

学校读者我要写书评

暂无评论

金属热处理 2015年第6期40卷 97-100页

作者：李珊珊沈俊昶朱心昆苏航程建华昆明理工大学材料科学与工程学院云南昆明650093 钢铁研究总院工程用钢所北京100081

运用光学(OM)、扫描(SEM)和透射(TEM)电镜等方法,研究了不同时效温度下高强度含Cu钢的力学性能,并对微观组织结构进行了系统分析。结果表明,时效温度为640℃时,钢的强度超过785 MPa,该钢可以获得良好的低温韧性和塑性匹配。分析得出ε-C... 详细信息

运用光学(OM)、扫描(SEM)和透射(TEM)电镜等方法,研究了不同时效温度下高强度含Cu钢的力学性能,并对微观组织结构进行了系统分析。结果表明,时效温度为640℃时,钢的强度超过785 MPa,该钢可以获得良好的低温韧性和塑性匹配。分析得出ε-Cu的析出强化、板条结构的回火马氏体组织及"有效晶粒尺寸"的细化,是试验钢获得优良综合性能的主要原因。

关键词：高强度含Cu钢时效温度组织性能

四川酿酒与非酿酒小麦品种的品质性状比较研究

在线全文

学校读者我要写书评

暂无评论

四川农业大学学报 2023年第3期41卷 389-392,408页

作者：吴丽娟申世安王军强胡信坤西华师范大学生态研究院四川南充637009 四川农业大学农学院成都611130

【目的】比较分析四川酿酒与非酿酒小麦品种之间的品质性状差异,为四川酿酒小麦品种选育提供理论依据。【方法】以3个酿酒和3个非酿酒小麦品种为试验材料,采用淀粉测定试剂盒法和凯氏定氮法分别测定淀粉含量和粗蛋白含量,并结合籽粒硬... 详细信息

【目的】比较分析四川酿酒与非酿酒小麦品种之间的品质性状差异,为四川酿酒小麦品种选育提供理论依据。【方法】以3个酿酒和3个非酿酒小麦品种为试验材料,采用淀粉测定试剂盒法和凯氏定氮法分别测定淀粉含量和粗蛋白含量,并结合籽粒硬度测定仪和近红外光谱仪对硬度指数和其他品质性状指标进行检测。【结果】3个酿酒小麦的平均总淀粉含量大于60%,平均支链淀粉含量占总淀粉含量的70%以上,均显著高于3个非酿酒小麦。它们的平均粗蛋白含量小于13%,仅与内麦101差异显著,但硬度指数和沉降值显著低于3个非酿酒小麦。此外,吸水率、稳定时间和湿面筋含量也显著低于部分非酿酒小麦。这表明3个酿酒小麦都属弱筋小麦。【结论】表明粗蛋白含量低于13%的优质弱筋小麦非常适合选作酿酒小麦品种。

关键词：小麦酿酒弱筋小麦品质性状