Phenylboronic acid-modified hollow silica nanoparticles for dual-responsive delivery of doxorubicin for targeted tumor therapy

作     者：Ling Huang Qingfeng Zhang Liangliang Dai Xinkun Shen Weizhen Chen Kaiyong Cai 

作者机构：Key Laboratory of Biorheological Science and TechnologyMinistry of Education College of BioengineeringChongqing UniversityChongqing 400044P.R.China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2017年第4卷第2期

页      面：111-124页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was financially supported by National Natural Science Foundation of China(21274169 and 31200712) Innovation Team in University of Chongqing Municipal Government(CXTDX201601002) Natural Science Foundation of Chongqing Municipal Government(CSTC2013kjrcljrcpy0004,2013jjB50004) 

主　　题：hollow mesoporous silica nanoparticles dual-response drug delivery targeted tumor therapy in vivo 

摘      要：This work reports a multifunctional nanocarrier based on hollow mesoporous silica nanoparticles(HMSNs)for targeting tumor ***(DOX)was loaded into HMSNs and blocked with cytochrome C conjugated lactobionic acid(CytC–LA)via redox-cleavable disulfide bonds and pH-disassociation boronate ester bonds as intermediate *** CytC–LA was used both as sealing agent and targeting motif.A series of characterizations demonstrated the successful construction of the drug delivery *** system demonstrated pH and redox dual-responsive drug release behavior in *** DOX loading HMSNs system displayed a good biocompatibility,which could be specifically endocytosed by HepG2 cells and led to high cytotoxicity against tumor cells by inducing cell *** vivo data(tumor volume,tumor weight,terminal deoxynucleotidyl transferase dUTP nick end labeling and hematoxylin and eosin staining)proved that the system could deliver DOX to tumor site with high efficiency and inhibit tumor growth with minimal toxic side effect.