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Regulatory role of electroacupuncture on satellite glial cell activity in the colon and dorsal root ganglion of rats with irritable bowel syndrome

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Journal of Traditional Chinese Medicine 2024年第5期44卷 981-990页

作者： ZHANG Fang YAN Cuina WENG Zhijun WU Luyi QI Li ZHAO Min xin yuhu WU Huangan LIU Huirong Key Laboratory of Acupuncture and Immunological Effects Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine Cancer Hospital Fudan University

OBJECTIVE: To investigate the role of satellite glial cells in irritable bowel syndrome(IBS) and the effect of electroacupuncture(EA) at the Tianshu(ST25) and Shangjuxu(ST37) combination. METHODS: A model for visceral hypersensitivity in IBS was induced through colorectal distension(CRD) stimulation. Clean-grade male Sprague-Dawley(SD) rats were randomly divided into four groups: a normal group(NG), a model group(MG), an electroacupuncture group(EA), and a glial cell inhibitor group(FCA). Bilateral EA(2/100 Hz, 1 mA, 30 min) was administered at the Tianshu(ST25) and Shangjuxu(ST37) in week 6. Abdominal withdrawal reflex(AWR) scores were used to assess the behavioral response associated with visceral hyperalgesia, while hematoxylin-eosin staining was employed to evaluate pathological changes in the colon. The protein and mRNA levels of glial fibrillary acidic protein(GFAP) in the colon and colon-related dorsal root ganglion(DRG) were analyzed using immun-ofluorescence, immunohistochemistry, Western blotting, real-time polymerase chain reaction. The impact of EA on electrophysiological properties of colon-related DRG neurons was observed through whole-cell patch clamp analysis. RESULTS: EA significantly reduced the visceral pain behavior scores in rats with IBS in response to graded(20, 40, 60, 80 mm Hg) CRD stimulation. Additionally, EA downregulated the protein and mRNA expression levels of GFAP in the colon and colon-related DRG of rats with IBS. EA also regulated the resting membrane potential, rheobase and action potential of colon-related DRG neurons in rats with IBS. CONCLUSIONS: EA can regulate the excitatory properties of colon-related DRG neurons by downregulating the protein and mRNA expression of GFAP in the colon and colon-related DRG, indicating a potential neurobiological mechanism by which EA relieves visceral hypersensitivity in rats with IBS.

关键词： electroacupuncture glial fibrillary acidic proteinSupporting information irritable bowel syndrome satellite glial cell visceral hypersensitivity

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Electroacupuncture diminishes P2X_2 and P2X_3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity

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Neural Regeneration Research 2013年第9期8卷 802-808页

作者： Zhijun Weng Luyi Wu Yuan Lu Lidong Wang Linying Tan Ming Dong yuhu xin Shanghai Academy of Traditional Chinese Medicine Fudan University Shanghai Cancer Center

Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia.

关键词： neural regeneration acupuncture and moxibustion P2X2 P2X3 visceral hypersensitivity irritablebowel syndrome electroacupuncture P2 purinergic receptors abdominal withdrawal reflex scoresacupuncture and moxibustion peripheral nerve injury grants-supported paper photographscontaining paper neuroregeneration

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Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity

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Neural Regeneration Research 2013年第22期8卷 2069-2077页

作者： xinxin Guo Jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang yuhu xin Xianming Lin Yi Liang Jianqiao Fang Third Affiliated Hospital of Zhejiang Chinese Medical University Department of Orthopedics Zhongshan Hospital of Fudan University Shanghai Institute for Traditional Chinese Medicine Cancer Hospital Fudan University

Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome, Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immunore- activity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord,

关键词： neural regeneration traditional Chineseture irritable bowel syndrome visceralported paper neuroregenerationmedicine combination of He-Mu points electroacupunc-hypersensitivity P2X4 receptor acupuncture grants-sup-

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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中亚的俄罗斯人问题研究——以水利灌溉工程建设为线索

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西伯利亚研究 2024年第1期51卷 107-118页

作者：王苑李新叶玉虎上海政法学院经济管理学院上海政法学院欧亚研究所白俄罗斯国立大学国际关系学院

19世纪70年代,沙俄政府占领中亚地区后便开始向当地移民并通过积极修建水利灌溉工程发展移民定居点。苏联时期中亚地区更是开展了大规模的水利灌溉设施建设,随着工程的发展,大量俄罗斯人涌入中亚,对中亚地区的工农业结构造成一定影响,... 详细信息

19世纪70年代,沙俄政府占领中亚地区后便开始向当地移民并通过积极修建水利灌溉工程发展移民定居点。苏联时期中亚地区更是开展了大规模的水利灌溉设施建设,随着工程的发展,大量俄罗斯人涌入中亚,对中亚地区的工农业结构造成一定影响,在推动中亚经济社会发展的同时也为日后中亚地区生态环境恶化和民族矛盾激化埋下了祸根。苏联解体后,中亚地区的生态环境以及政治环境均发生变化,由跨界水资源分配问题带来的各种矛盾迅速激化,引发多次武装冲突和流血事件,尤其是灌溉工程的萎缩使大批俄罗斯移民失去赖以生存的条件,间接导致俄罗斯人离开中亚,进而显著改变了中亚的社会人口结构,对中亚地区的影响较为深远。

关键词：俄罗斯人灌溉工程中亚

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电针对IBS内脏痛大鼠脊髓GFAP、P2X3受体的调节作用

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世界科学技术-中医药现代化 2021年第8期23卷 2919-2927页

作者：周云张方翁志军张智英沈佳成忽世秀辛玉虎吴焕淦刘慧荣上海中医药大学针灸免疫效应重点研究室上海200030 上海市针灸经络研究所上海200030 复旦大学附属肿瘤医院上海200032

目的探讨脊髓星形胶质细胞和P2X3受体在电针缓解肠易激综合征(Irritable Bowel Syndrome,IBS)大鼠内脏痛的调节作用机制。方法采用直结肠球囊扩张(Colorectal dilatation,CRD)刺激诱导IBS慢性内脏痛模型。将清洁级SD(Sprague-Dawley)雄... 详细信息

目的探讨脊髓星形胶质细胞和P2X3受体在电针缓解肠易激综合征(Irritable Bowel Syndrome,IBS)大鼠内脏痛的调节作用机制。方法采用直结肠球囊扩张(Colorectal dilatation,CRD)刺激诱导IBS慢性内脏痛模型。将清洁级SD(Sprague-Dawley)雄性新生大鼠随机分为正常组和造模组。通过行为学评分和结肠形态学方法鉴定模型制备成功后将造模组随机分为模型组、电针组、氟代柠檬酸组。电针组取双侧上巨虚穴(S37)、天枢穴(S25)进行电针治疗,针刺深度为5 mm,30 min/次,每日1次,连续治疗7天。氟代柠檬酸组鞘内注射氟代柠檬酸10μL,每周3次。治疗结束后,采用腹部撤回反射(Abdominal Withdrawal Reflex,AWR)评分评估电针对IBS内脏痛大鼠行为学影响;采用HE染色观察IBS内脏痛大鼠的结肠组织病理形态学变化;采用免疫组织化学、Western Blot等方法检测脊髓中星形胶质细胞标志物胶质纤维酸性蛋白(Glial fibrillary acidic protein,GFAP)和P2X3受体蛋白表达。结果与正常组相比,模型组大鼠AWR评分显著升高,脊髓中GFAP和P2X3受体表达水平明显增多;与模型组比较,电针组、氟代柠檬酸组大鼠AWR评分明显降低,脊髓中GFAP、P2X3受体的表达明显降低。结论电针能够有效缓解IBS大鼠内脏痛敏,其镇痛效应可能与其抑制脊髓GFAP和P2X3受体表达有关。

关键词：电针 IBS 内脏痛 GFAP P2X3 脊髓

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Cenozoic uplift of the Tibetan Plateau:Evidence from the tectonic-sedimentary evolution of the western Qaidam Basin

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Geoscience Frontiers 2012年第2期3卷 175-187页

作者： Yadong Wang Jianjing Zheng Weilin Zhang Shiyuan Li xingwang Liu xin Yang yuhu Liu Key Laboratory of Petroleum Resources Research Institute of Geology and Geophysics Chinese Academy of Sciences Donggang WestRoad No. 382 Lanzhou 730000 China Center for Basin Resource and Environment Institute of Tibetan Plateau Research Chinese Academy of Sciences Post Box 2871 BeilinNorth Street 18 Beijing 100085 China Research Institute of Petroleum Exploration and Development PetroChina Qinghai Oilfield Company Dunhuang 736202 China Exploration and Development Academy of Northeast Petroleum Branch China Petroleum ＆ Chemical Corporation Changchun 130061China

Geologists agree that the collision of the Indian and Asian plates caused uplift of the Tibet Plateau. However, controversy still exists regarding the modes and mechanisms of the Tibetan Plateau uplift. Geology has recorded this uplift well in the Qaidam Basin. This paper analyzes the tectonic and sedimentary evolution of the western Qaidam Basin using sub-surface seismic and drill data. The Cenozoic intensity and history of deformation in the Qaidam Basin have been reconstructed based on the tectonic developments, faults growth index, sedimentary facies variations, and the migration of the depositional depressions. The changes in the sedimentary facies show that lakes in the western Qaidam Basin had gone from inflow to still water deposition to withdrawal. Tectonic movements controlled deposition in various depressions, and the depressions gradually shifted southeastward. In addition, the morphology of the surface structures in the western Qaidam Basin shows that the Cenozoic tectonic movements controlled the evolution of the Basin and divided it into （a） the southern fault terrace zone, （b） a central Yingxiongling orogenic belt, and （c） the northern fold-thrust belt; divided by the XI fault （Youshi fault） and Youbei fault, respectively. The field data indicate that the western Qaidam Basin formed in a Cenozoic compressive tectonic environment caused by the India--Asia plate collision. Further, the Basin experienced two phases of intensive tectonic deformation. The first phase occurred during the Middle Eocene--Early Miocene （Xia Ganchaigou Fm. and Shang Ganchaigou Fro., 43.8- 22 Ma）, and peaked in the Early Oligocene （Upper Xia Ganchaigou Fro., 31.5 Ma）. The second phase occurred between the Middle Miocene and the Present （Shang Youshashan Fro. and Qigequan Fro., 14.9-0 Ma）, and was stronger than the first phase. The tectonic--sedimentary evolution and the orienta- tion of surface structures in the western Qaidam Basin resulted from the Tibetan Plateau uplift, and

关键词： Western Qaidam Basin Sedimentary facies Depositional depressionTectonic evolution Tibetan Plateau uplift

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An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization

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Advances in Atmospheric Sciences 2020年第9期37卷 939-950页

作者： Mingkui LI Shaoqing ZHANG Lixin WU Xiaopei LIN Ping CHANG Gohkan DANABASOGLU Zhiqiang WEI Xiaolin YU Huiqin HU Xiaohui MA Weiwei MA Haoran ZHAO Dongning JIA xin LIU Kai MAO Youwei MA Yingjing JIANG Xue WANG Guangliang LIU yuhu CHEN Key Laboratory of Physical Oceanography MOEInstitute for Advanced Ocean StudyCollege of Ocean and AtmosphereFrontiers Science Center for Deep Ocean Multispheres and Earth System(DOMES)Ocean University of ChinaQingdao 266100China Pilot National Laboratory for Marine Science and Technology(QNLM) Qingdao 266237China International Laboratory for High-Resolution Earth System Model and Prediction(iHESP) Qingdao 266237China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China Department of Oceanography Texas A&M UniversityCollege StationTexas 77843USA National Center for Atmospheric Research BoulderColorado 80301USA National Supercomputing Jinan Center Jinan 250101China

Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically *** requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled *** study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West *** APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km *** this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC *** the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions.

关键词： high-resolution coupled model tropical cyclone formation predictability TC genesis coupled data assimilation

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基于FRFT的雷达辐射源信号特征分析及提取

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探测与控制学报 2018年第2期40卷 71-76页

作者：关欣朱杭平张玉虎海军航空工程学院山东烟台264001

针对用于分选的雷达辐射源信号参数空间严重交错的问题,提出了基于分数阶傅里叶变换(FRFT)的雷达辐射源信号特征分析与提取方法。该方法提出特征定义——信号聚散度,同时将相像系数引入信号特征的提取中。通过计算不同阶FRFT中的聚散度... 详细信息

针对用于分选的雷达辐射源信号参数空间严重交错的问题,提出了基于分数阶傅里叶变换(FRFT)的雷达辐射源信号特征分析与提取方法。该方法提出特征定义——信号聚散度,同时将相像系数引入信号特征的提取中。通过计算不同阶FRFT中的聚散度和相像系数得到相应的变化曲线,提取曲线峰值对应的阶数值和峰度,并进一步提取信号做k次方谱的相像系数,以此构造新的分选特征向量。通过仿真实验验证了新特征向量具有更好的可分性。

关键词：分数阶傅里叶变换特征分析聚散度相像系数

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Catechol-O-Methyltransferase Val158Met polymorphism influences prefrontal executive function in Han Chinese patients with Parkinson's disease

Catechol-O-Methyltransferase Val158Met polymorphism influenc...

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第四届全国痴呆与认知障碍学术研讨会及高级讲授班

作者： Zhang Youwen Feng Shujun Nie Kun Zhao xin Gan Rong Gao Liang Tang Hongmei Zhu Ruiming Wang Limin Zhao Jiehao Wang Lijuan Zhang yuhu Department of Neurology Guangdong Neuroscience Institute Guangdong General Hospital Guangdong Academy of Medical Sciences

Objective The Catechol-O-Methyltransferase(COMT)Val158Met polymorphism has been proposed to be associated with increased risk of PD and have a specific impact on dopamine-mediated prefrontal executive function in an inverted-U curve *** tested this hypothesis in a well-established Chinese cohort of PD *** The COMT gene(rs4608)was genotyped in 304 PD patients and 350 healthy

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