Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity

作     者：Xinxin Guo Jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang Yuhu Xin Xianming Lin Yi Liang Jianqiao Fang 

作者机构：Third Affiliated Hospital of Zhejiang Chinese Medical University Department of OrthopedicsZhongshan Hospital of Fudan University Shanghai Institute for Traditional Chinese Medicine Cancer HospitalFudan University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第22期

页      面：2069-2077页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.30973783 the Open Research Fund of Zhejiang First-foremost Key Subject--Acupuncture & Moxibustion,No.ZTK2010A01 the scientific research grants of Shanghai Health Bureau,No.2009209 

主　　题：neural regeneration traditional Chineseture irritable bowel syndrome visceralported paper neuroregenerationmedicine combination of He-Mu points electroacupunc-hypersensitivity P2X4 receptor acupuncture grants-sup- 

摘      要：Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome, Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immunore- activity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord,