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采用动态双子群策略改进的灰狼算法及其在心电信号识别中的应用

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传感技术学报 2021年第3期34卷 420-426页

作者：刘继忠谢毓顺徐文斌邓家诚李继发丁亚飞南昌大学南昌市医工结合研究重点实验室江西南昌330031

针对基本灰狼优化算法(GWO)易陷入局部最优的缺点,将双子群策略引入灰狼算法,提出一种采用动态双子群策略改进的灰狼算法(DDGWO)。该算法动态的将灰狼种群划分为较优子群和较差子群,较优子群与较差子群采用不同的非线性收敛因子,在进行... 详细信息

针对基本灰狼优化算法(GWO)易陷入局部最优的缺点,将双子群策略引入灰狼算法,提出一种采用动态双子群策略改进的灰狼算法(DDGWO)。该算法动态的将灰狼种群划分为较优子群和较差子群,较优子群与较差子群采用不同的非线性收敛因子,在进行全局搜索时,能够有效避免陷入局部最优。本文将DDGWO应用于SVM参数优化,并建立DDGWO-SVM模型进行心电信号识别实验,并与其他算法进行性能测试对比。结果表明,DDGWO具有更好的寻优特性,所建立的DDGWO-SVM模型获得了更高的心电分类识别精度。

关键词：元启发式算法灰狼优化算法动态双子群策略非线性收敛因子支持向量机心电信号识别

Apoptosis of A549 cells by small interfering RNA targeting survivin delivery using poly-β-amino ester/guanidinylated O-carboxymethyl chitosan nanoparticles

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 121-128页

作者： Yue Tang Yun Liu Yuwen xie Jing Chen yushun Dou Department of Pharmacy China Pharmaceutical UniversityNanjing 211198China

Gene-based therapeutics has emerged as a promising approach for human cancer therapy. Among a variety of non-viral vectors, polymer vectors are particularly attractive due to their safety and multivalent groups on their surface. This study focuses on guanidinylated O-carboxymethyl chitosan(GOCMCS) along with poly-β-amino ester(PBAE) for si RNA delivery. Binding efficiency of PBAE/si RNA/GOCMCS nanoparticles were characterized by gel electrophoresis. The si RNA-loaded nanoparticles were found to be stable in the presence of RNase A, serum and BALF respectively. Fine particle fraction(FPF) which was determined by a two-stage impinger(TSI) was 57.8% ± 2.6%. The particle size and zeta potential of the nanoparticles were 153.8 ± 12.54 nm and + 12.2 ± 4.94 m V. In vitro cell transfection studies were carried out with A549 cells. The cellular uptake was significantly increased. When the cells were incubated with si Survivin-loaded nanoparticles, it could induce 26.83% ± 0.59% apoptosis of A549 cells and the gene silencing level of survivin expression in A549 cells were 30.93% ± 2.27%. The results suggested that PBAE/GOCMCS nanoparticle was a very promising gene delivery carrier.

关键词： Poly-β-amino ester Guanidinylated O-carboxymethyl chitosan Nanoparticles Gene delivery

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基于云通讯的监护系统多生理数据传输策略

南昌大学学报（工科版） 2020年第4期42卷 397-403页

作者：刘继忠徐文斌谢毓顺刘鸿郑莉萍南昌大学南昌市医工结合技术研究重点实验室江西南昌330031

为提高监护系统远程数据传输的准确性、实时性,提出了一种基于云通讯平台的多生理参数实时传输策略。该策略方法结合云通讯平台技术,设计了数据传输通讯协议、数据加密校验机制、反馈机制、多队列数据缓存机制等多种传输机制来降低网络... 详细信息

为提高监护系统远程数据传输的准确性、实时性,提出了一种基于云通讯平台的多生理参数实时传输策略。该策略方法结合云通讯平台技术,设计了数据传输通讯协议、数据加密校验机制、反馈机制、多队列数据缓存机制等多种传输机制来降低网络通信过程中对监护系统多生理参数数据的不利影响,有效地减少数据丢包,降低时延,提高数据远程传输的实时性、准确性、完整性和连续性,并已实际应用于所开发的多生理参数远程健康监护系统中。

关键词：远程数据传输云通讯平台传输机制监护系统

Extracting Relevant Terms from Mashup Descriptions for Service Recommendation

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Tsinghua Science and Technology 2017年第3期22卷 293-302页

作者： Yang Zhong yushun Fan Department of Automation Tsinghua UniversityBeijing 100084China

Due to the exploding growth in the number of web services, mashup has emerged as a service composition technique to reuse existing services and create new applications with the least amount of effort. Service recommendation is essential to facilitate mashup developers locating desired component services among a large collection of candidates. However, the majority of existing methods utilize service profiles for content matching, not mashup descriptions. This makes them suffer from vocabulary gap and cold-start problem when recommending components for new mashups. In this paper, we propose a two-step approach to generate high-quality service representation from mashup descriptions. The first step employs a linear discriminant function to assign each term with a component service such that a coarse-grained service representation can be derived. In the second step, a novel probabilistic topic model is proposed to extract relevant terms from coarse-grained service representation. Finally, a score function is designed based on the final high-quality representation to determine recommendations. Experiments on a data set from *** show that the proposed model significantly outperforms state-of-the-art methods.

关键词： service recommendation topic model mashup descriptions linear discriminant function

Environmental filtering and spatial processes equally contributed to macroinvertebrate metacommunity dynamics in the highly urbanized river networks in Shenzhen, South China

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Ecological Processes 2021年第1期10卷 316-327页

作者： Zhenyuan Liu Tingting Zhou Yongde Cui Zhengfei Li Weimin Wang yushun Chen Zhicai xie Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072HubeiChina University of Chinese Academy of Sciences Beijing 100049China Central Station for Environmental Monitoring and Assessment Shenzhen 518049GuangdongChina.

Background:Disentangling the relative roles of environmental filtering and spatial processes in structuring ecological communities is a central topic in metacommunity *** ecology in the temperate river ecosystems has been well developed,while less attention has been paid to subtropical urban river ***,we examined the ecological factors and seasonal difference in structuring macroinvertebrates metacommunity assembly in the subtropical urban river networks in Shenzhen,South ***:Our results revealed that there was no significant distinction of macroinvertebrate community composition among seasons,with only the relative abundance of Mollusca and Odonata significantly differed in both wet and dry *** possible explanation was that most macroinvertebrates are generally pollution-tolerant taxa characterized with nonseasonal life *** addition,distance-based redundancy analysis and variation partitioning approach revealed that metacommunity was determined equally by the environmental and dispersal-related ***,our results showed that,although a slight temporal variation of relative contribution,the identity and explanation power of ecological factors were different among ***,stronger environmental filtering structuring community dynamics was observed in the dry than wet seasons,which might be owing to higher environmental heterogeneity under a low water-flow ***,we detected that the influence of spatial processes was stronger in the wet than dry seasons,indicating an obvious dispersal processes due to high connectivity among ***:Overall,our results revealed that environmental and spatial factors equally explained variations of macroinvertebrate metacommunity,implying the necessity of considering dispersal-related processes structuring ecological communities in river bioassessment ***,degraded habitat conditions and water quality were the predominant factors

关键词： Community assembly Seasonal variation Macroinvertebrate metacommunity Environmental filtering Spatial processes Urban river

MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-λ1

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Protein & Cell 2013年第2期4卷 130-141页

作者： Yongkui Li Jiajia xie Xiupeng Xu Jun Wang Fang Ao yushun Wan Ying Zhu The State Key Laboratory of Virology and College of Life Sciences Wuhan UniversityWuhan 430072China Wuhan Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Interferon(IFN)-mediated pathways are a crucial part of the cellular response against viral *** III IFNs,which include IFN-λ1,2 and 3,mediate antiviral responses similar to Type I IFNs via a distinct receptor ***-λ1 is more effective than the other two *** of IFN-λ1 requires activation of IRF3/7 and nuclear factor-kappa B(NF-κB),similar to the transcriptional mechanism of Type I *** reporter assays,we discovered that viral infection in-duced both IFN-λ1 promoter activity and that of the 3′-untranslated region(UTR),indicating that IFN-λ1 expression is also regulated at the post-transcriptional *** analysis with microRNA(miRNA)prediction programs and 3′UTR targeting site assays,the miR-NA-548 family,including miR-548b-5p,miR-548c-5p,miR-548i,miR-548j,and miR-548n,was identified to target the 3′UTR of IFN-λ*** study demonstrated that miRNA-548 mimics down-regulated the expression of IFN-λ*** contrast,their inhibitors,the complemen-tary RNAs,enhanced the expression of IFN-λ1 and IFN-stimulated ***,miRNA-548 mimics promoted infection by enterovirus-71(EV71)and ve-sicular stomatitis virus(VSV),whereas their inhibitors significantly suppressed the replication of EV71 and *** miRNA-548 levels were suppressed during viral *** conclusion,our results sug-gest that miRNA-548 regulates host antiviral response via direct targeting of IFN-λ1,which may offer a poten-tial candidate for antiviral therapy.

关键词： microRNA-548 interferon-λ1 viral infec-tion antiviral response

HIGH ORDER COMPACT MULTISYMPLECTIC SCHEME FOR COUPLED NONLINEAR SCHRODINGER-KDV EQUATIONS

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Journal of Computational Mathematics 2018年第4期36卷 591-604页

作者： Lan Wang yushun Wang Jiangsu Key Laboratory of NSLSCS School of Mathematical Sciences Nanjing Normal University Nanjing 210023 China School of Mathematics and Information Science Jiangxi Normal University Nanchang 330022 China

In this paper, a novel multisymplectic scheme is proposed for the coupled nonlinear Schrodinger-KdV （CNLS-KdV） equations. The CNLS-KdV equations are rewritten into the multisymplectic Hamiltonian form by introducing some canonical momenta. To simulate the problem efficiently, the CNLS-KdV equations are approximated by a high order compact method in space which preserves N semi-discrete multisymplectic conservation laws. We then discretize the semi-discrete system by using a symplectic midpoint scheme in time. Thus, a full-discrete multisymplectic scheme is obtained for the CNLS-KdV equations. The conservation laws of the full-discrete scheme are analyzed. Some numerical experiments are presented to further verify the convergence and conservation laws of the new scheme.

关键词： Schrodinger-KdV equations High order compact method Conservation law Multisymplectic scheme

α-亚麻酸通过TLR4/MyD88/NF-κB信号通路抑制脂多糖诱导的巨噬细胞炎症

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食品工业科技 2025年第1期46卷 377-383页

作者：蔡瑞鑫陈小蝶朱海彬钱雨顺谢建华申明月南昌大学食品科学与资源挖掘全国重点实验室江西南昌330047

ω-3脂肪酸具有自然的抗炎属性,而α-亚麻酸(ALA)是一种人体必需的ω-3脂肪酸,为了阐明其体外抗炎机制,本实验采用脂多糖(LPS)刺激巨噬细胞构建炎症模型,通过测定单核细胞趋化蛋白(MCP-1)、白细胞介素4(IL-4)、白细胞介素13(IL-13)等炎... 详细信息

ω-3脂肪酸具有自然的抗炎属性,而α-亚麻酸(ALA)是一种人体必需的ω-3脂肪酸,为了阐明其体外抗炎机制,本实验采用脂多糖(LPS)刺激巨噬细胞构建炎症模型,通过测定单核细胞趋化蛋白(MCP-1)、白细胞介素4(IL-4)、白细胞介素13(IL-13)等炎症因子的水平、活性氧(ROS)生成量和炎症信号通路相关蛋白表达情况探讨α-亚麻酸减轻脂多糖诱导的炎症反应的机制。结果表明,α-亚麻酸能显著抑制MCP-1的释放,提高抗炎细胞因子IL-13的分泌水平;同时,α-亚麻酸还可以降低ROS生成量,缓解ROS介导的炎性损伤。此外,α-亚麻酸可以通过增加抗氧化酶SOD的表达,减少MDA的堆积,从而减轻炎症反应中氧化应激的伴随性危害。蛋白印迹分析进一步证实,α-亚麻酸可抑制TLR4、MyD88的表达以及下游p65和IκBα的磷酸化水平。以上结果表明,α-亚麻酸可明显抑制LPS诱导的RAW264.7细胞炎症反应,其机制可能与抑制TLR4/MyD88/NF-κB信号通路激活有关。

关键词： α-亚麻酸巨噬细胞炎症信号通路

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LOCAL STRUCTURE-PRESERVING ALGORITHMS FOR THE KDV EQUATION

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Journal of Computational Mathematics 2017年第3期35卷 289-318页

作者： Jialing Wang yushun Wang Jiangsu Key Laboratory of NSLSCS School of Mathematical Sciences Nanjing Normal University Nanjing 210023 China

In this paper, based on the concatenating method, we present a unified framework to construct a series of local structure-preserving algorithms for the Korteweg-de Vries （KdV） equation, including eight multi-symplectic algorithms, eight local energy-conserving algo- rithms and eight local momentum-conserving algorithms. Among these algorithms, some have been discussed and widely used while the most are new. The outstanding advantage of these proposed algorithms is that they conserve the local structures in any time-space re- gion exactly. Therefore, the local structure-preserving algorithms overcome the restriction of global structure-preserving algorithms on the boundary conditions. Numerical experiments are conducted to show the performance of the proposed methods. Moreover, the unified framework can be easily applied to many other equations.

关键词： Korteweg-de Vries (KdV) equation Structure-preserving algorithms Concate-nating method Multi-symplectic conservation law.