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Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 385-392页

作者： Min-Zhi Chen Ping Xie xiao-Chang wu Zhen-Hua Tan Hai Qian Zhi-hong Ma Xing Yao Department of Hepatopancreatobiliary Surgery Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China Huzhou Key Laboratory of Molecular Medicine Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China

Background: Obesity is a common public health issue and is currently deemed a disease. Research has shown that the risk of gallstones in individuals with obesity is elevated. This study aimed to explore the bile proteomics differences between cholelithiasis patients with obesity and normal body weight. Methods: Bile samples from 20 patients(10 with obesity and 10 with normal body weight) who underwent laparoscopic cholecystectomy at our center were subjected to tandem mass tag labeling(TMT) and liquid chromatography-tandem mass spectrometry(LC-MS/MS), followed by further bioinformatic analysis. Results: Among the differentially expressed proteins, 23 were upregulated and 67 were downregulated. Bioinformatic analysis indicated that these differentially expressed proteins were mainly involved in cell development, inflammatory responses, glycerolipid metabolic processes, and protein activation cascades. In addition, the activity of the peroxisome proliferator-activated receptor(PPAR, a subfamily of nuclear receptors) signaling pathway was decreased in the Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Two downregulated proteins in the PPAR signaling pathway, APO A-Ⅰ and APO A-Ⅱ, were confirmed using enzyme-linked immunosorbent assay. Conclusions: The PPAR signaling pathway may play a crucial role in the development of cholelithiasis among patients with obesity. Furthermore, biliary proteomics profiling of gallstones patients with obesity is revealed, providing a reference for future research.

关键词： Proteome profiling Gallstones Obesity-associated gallstones Tandem mass tag labeling PPAR signaling

Interstitial carbon induces enriched Cu^(δ+) sites in Cu_(2)O nanoparticles to facilitate CO_(2) electroreduction to C_(2+) products

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Nano Research 2024年第8期17卷 7013-7019页

作者： Haoran Wang Rongbo Sun Peigen Liu Haohui Hu Chen Ling xiao Han Yi Shi Xusheng Zheng Geng wu Xun hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Sinochem Holdings Co Ltd Xiongan New AreaHebei 071700China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China

The electrochemical CO_(2) reduction reaction(CO_(2)RR)holds significant promise in advancing carbon *** catalysts for the electrochemical CO_(2)RR to multi-carbon(C_(2+))products(e.g.,C_(2)H_(4))under industrial-level current density is urgently needed and ***,we report the Cu_(2)O nanoparticles doped with interstitial carbon atoms(denoted as C-Cu_(2)O NPs)for the conversion of CO_(2) to C_(2+)*** interstitial carbon promotes the C-Cu_(2)O NPs to possess abundant unsaturated Cu–O bonds,leading to a high-density Cu^(δ+)(0<δ<1)*** obtained C-Cu_(2)O NPs exhibited significant Faradic efficiency(FE)of C_(2+) products approaching 76.9%and a partial current density reaching 615.2 mA·cm^(–2)under an industrial-level current density of 800 mA·cm^(–2).Furthermore,the efficient electrosynthesis of C_(2)H_(4) achieved an FE of 57.4%with a partial current density of 459.2 mA·cm^(–2).In situ electrochemical attenuated total reflection Fourier transform infrared spectroscopy and in situ Raman spectroscopy analyses revealed that C-Cu_(2)O NPs stabilized the intermediate*CO and facilitated C–C coupling,leading to increased selectivity towards C_(2+) products.

关键词： CO_(2) electroreduction C-C coupling interstitial carbon *CO coverage industrial-level current density

Roles of Cu doping in YbZn_(2)Sb_(2) for thermoelectric performance enhancement

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Rare Metals 2024年第6期43卷 2869-2875页

作者： Xiong Zhang Hai-Hui Li xiao-Liang Cao Bin Zhang hong wu Yu Zhang Guang Han Guo-Yu Wang Hao-Shuang Gu xiao-Yuan Zhou College of Physics and Electronic Science Hubei Normal UniversityHuangshi 435002China Analytical and Testing Center Chongqing UniversityChongqing401331China School of Science Chongqing University of Posts and Telecommunications.Chongqing 400065 China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials-Hubei Key Laboratory of Ferro&Piezoelectric Materials and Devices Faculty of Physical and Electronic SciencesHubei UniversityWuhan 430062China College of Physics Chongqing UniversityChongqing 401331China

Recent research shows that increasing the carrier density after orbital alignment in AZn_(2)Sb_(2) (A=Ca,Yb,Eu,Sr,Mg)Zintl compounds yields remarkable results with regard to enhanced thermoelectric ***,research on carrier density increase via doping in these compounds is *** this study,we introduced Cu into the Zn sites in YbZn_(2)Sb_(2) and examined the thermoelectric properties.

关键词： properties doping performance

Investigation of high rate mechanical flow followed by ignition for high-energy propellant under dynamic extrusion loading

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Defence Technology（防务技术） 2024年第2期32卷 336-347页

作者： Liying Dong Yanqing wu Kun Yang xiao Hou State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

Investigating the ignition response of nitrate ester plasticized polyether(NEPE) propellant under dynamic extrusion loading is of great significant at least for two cases. Firstly, it helps to understand the mechanism and conditions of unwanted ignition inside charged propellant under accident ***, evaluates the risk of a shell crevice in a solid rocket motor(SRM) under a falling or overturning scene. In the present study, an innovative visual crevice extrusion experiment is designed using a dropweight apparatus. The dynamic responses of NEPE propellant during extrusion loading, including compaction and compression, rapid shear flow into the crevice, stress concentration, and ignition reaction, have been firstly observed using a high-performance high-speed camera. The ignition reaction is observed in the triangular region of the NEPE propellant sample above the crevice when the drop weight velocity was 1.90 m/s. Based on the user material subroutine interface UMAT provided by finite element software LS-DYNA, a viscoelastic-plastic model and dual ignition criterion related to plastic shear dissipation are developed and applied to the local ignition response analysis under crevice extrusion conditions. The stress concentration occurs in the crevice location of the propellant sample, the shear stress is relatively large, the effective plastic work is relatively large, and the ignition reaction is easy to occur. When the sample thickness decreases from 5 mm to 2.5 mm, the shear stress increases from 22.3 MPa to 28.6 MPa, the critical value of effective plastic work required for ignition is shortened from 1280 μs to 730 μs, and the triangular area is easily triggering an ignition reaction. The propellant sample with a small thickness is more likely to stress concentration, resulting in large shear stress and effective work, triggering an ignition reaction.

关键词： NEPE propellant Crevice extrusion Shear flow Sample thickness Ignition reaction

Redox-Active Dihydrophenazine-Based Macrocycle:Synthesis,Conformation-Adaptive Behavior and Host-Guest Complexation with Tetracyanoquinodimethane

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Chinese Journal of Chemistry 2024年第16期42卷 1895-1900页

作者： Qiong-Yan hong Bin Huang Meng-Xiang wu Lin Xu xiao-Li Zhao Xueliang Shi Hai-Bo Yang Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal University3663 N.Zhongshan RoadShanghai 200062China

A novel macrocycle based on conformation-adaptive and electron-rich dihydrophenazine was designed and *** the one hand,the macrocycle showed host-guest interactions with tetracyanoquinodimethane(TCNQ)driving by charge transfer interaction between ***,host-guest complexation was accompanied by fluorescence quenching and conformational change of the *** the other hand,the oxidation of the macrocycle resulted in its diradical cation analogue and induced the release of the guest molecule TCNQ,thereby accomplishing reversible binding ***,this work wellillustrates the chemical and structural versatility of dihydrophenazine in the synthesis of macrocycles and their host-guest chemistry.

关键词： Dihydrophenazine Macrocycle Conformational adaptation Redox-active Host-guest interactions Charge transfer interaction Organic radical Supramolecular chemistry

Bioinspired nanotransducers for neuromodulation

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Nano Research 2024年第2期17卷 618-632页

作者： Fan Yang Xiang wu Sa Cai Guosong hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

Attack-Resilient Distributed Cooperative Control of Virtually Coupled High-Speed Trains via Topology Reconfiguration

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1066-1068页

作者： Shunyuan xiao xiaohua Ge Qing wu the Institute of Advanced Technology Nanjing University of Posts and TelecommunicationsNanjing 210023China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia the School of Engineering and Technology Central Queensland UniversityRockhampton QLD 4701Australia

Dear Editor,This letter addresses the resilient distributed cooperative control problem of a virtually coupled train convoy under stochastic disturbances and cyber *** main purpose is to achieve distributed coordinati... 详细信息

关键词： prescribed Speed trains

Imide-pillared covalent organic framework protective films as stable zinc ion-conducting interphases for dendrite-free Zn metal anodes

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Journal of Energy Chemistry 2024年第10期97卷 470-477页

作者： xiaoman Ye Xuemei xiao Zhijing wu Xin wu Lin Gu Sheng Liu School of Chemical Engineering and Technology Sun Yat-sen University The Key Lab of Low-Carbon Chemistry & Energy Conservation of Guangdong Province Sun Yat-sen University

The notorious growth of zinc dendrite and the water-induced corrosion of zinc metal anodes（ZMAs）restrict the practical development of aqueous zinc ion batteries（AZIBs）.In this work,a zinc metallized,imide-pillared covalent organic framework（ZPC） protective film has been engineered as a stable Zn2+ion-conducting interphase to modulate interfacial kinetics and suppress side reactions for *** to bare Zn,ZPC@Zn exhibits a higher Zn2+ionic conductivity,a larger Zn2+transference number,a lower electronic conductivity,a smaller desolvation activation energy and correspondingly a significant suppression of corrosion,hydrogen evolution and Zn ***,the ZPC@Zn||ZPC@Zn symmetric cell obtains a cycling lifespan over 3000 h under 5 mA cm-2for 1 mA h *** ZPC@Zn||NH4V4O10coin-type full battery delivers a specific capacity of 195.8 mA h g-1with a retention rate of78.5% at 2 A g-1after 1100 cycles,and the ZPC@Zn||NH4V4O10pouch full cell shows a retention of70.1% in reversible capacity at 3 A g-1after 1100 *** present incorporation of imide-linked covalent organic frameworks in the surface modification of ZMAs will offer fresh perspectives in the search for ideal protective films for the practicality of AZIBs.

关键词： Aqueous zinc ion batteries Covalent organic frameworks Imide linkage Surface modification Zinc metal anodes

Expression and significance of hypoxia-inducible factor-1αand glucose transporter-1

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Expression and significance of hypoxia-inducible factor-1αa...